A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(<scp>iii</scp>) system

Rezaei, Behzad; Ensafi, Ali A.; Haghighatnia, Fariba

doi:10.1039/c2ay05381k

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Several methods have been used to quantify IP such as chemiluminescence [ 8 , 9 ], chromatographic-mass spectrometry (LC-MS) [ 10 ], chromatography [ 11 ], spectroscopy [ 12 ], or flow injection analysis [ 13 , 14 ]. However, the low sensitivity and the large amount of time required to carry out these analyses have led to the development of several electrochemical methods [ 1 , 2 , 3 , 7 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample

Olmo

Garoz‐Ruiz

Carazo

et al. 2020

Sensors

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UV/Vis absorption spectroelectrochemistry (SEC) is a multi-response technique that has been commonly used for the characterization of materials and the study of reaction mechanisms. However, it has been scarcely used for quantitative purposes. SEC allows us to obtain two analytical signals simultaneously, yielding a dual sensor in just one experiment. In the last years, our group has developed new devices useful for analysis. In this work, a SEC device in parallel configuration, based on optical fibers fixed on screen-printed electrodes, was used to determine isoprenaline in a commercial drug, using both, the electrochemical and the spectroscopic signals. In this commercial drug, isoprenaline is accompanied in solution by other compounds. Among them is sodium metabisulfite, an antioxidant that strongly interferes in the isoprenaline determination. A simple pretreatment of the drug sample by bubbling wet-air allows us to avoid the interference of metabisulfite. Here, we demonstrate again the capabilities of UV/Vis absorption SEC as double sensor for analysis and we propose a simple pretreatment to remove interfering compounds.

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Section: Introductionmentioning

confidence: 99%

Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample

Olmo

Garoz‐Ruiz

Carazo

et al. 2020

Sensors

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“…2 It is mostly used to treat bradycardia, heart block, chronic obstructive pulmonary diseases and rare in asthma, and as an active bronchodilator. [3][4][5] The literature review on availability of analytical methods to identify isoproterenol hydrochloride and its metabolites in biological samples such as high performance liquid chromatography, liquid chromatography-mass spectrometry (LC-MS) 6,7 gas-liquid chromatography 8 and poly vinylchloride membrane selective electrode 9 , selective separation using bismuth silicate ion-exchanger 10 , chemiluminescence determination using luminol-diperiodatoargentate(III) 11 and characterization of new process related impurity using HPLC, LC/ESI-MS, NMR. 12 A sensitive spectrophotometric method recently has been developed for the determination of isopropyl amine, a core moiety of isoproterenol hydrochloride, at the trace level in pharmaceutical drug substances.…”

Section: Introductionmentioning

confidence: 99%

Stability Indicating Method Development and Validation for the Quantification of Isoproterenol HCL in Bulk and Its Formulation by Rp-HPLC Using Pda Detection

Muneer¹,

Ahad²,

Bonnoth³

2018

J. Pharm. Sci. Innov.

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The objective of the present study was to develop an accurate, precise stability indicating reverse phase liquid chromatographic method to quantify Isoproterenol HCl in bulk and its formulation using PDA detection. The chromatographic separation of the analyte from the degradants was achieved on Phenomenex Luna column with mobile phase composition of Methanol and 0.1% Triethyl amine [pH 7.0], [20:80% v/v] at flow rate of 1.0 ml/min. The analyte separation was monitored using PDA detection at 279nm. The method was linear in the concentration range of 10-60 μg/ml. The method shown acceptable percent relative deviations for the Inter-day (0.58%) and Intra-day (0.65%) precisions. The mean percent recovery for accuracy study was within the limit. From the stability studies method has proven specificity to quantify Isoproterenol HCl in presence of its degradation products. The method shown acceptance as according to ICH guidelines.

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“…Several methods have been reported to identify isoproterenol hydrochloride and its metabolites in biological samples such as high performance liquid chromatography (HPLC), liquid chromatography–mass spectrometry (LC–MS) [5] , [6] , gas-liquid chromatography (GLC) [7] and poly(vinylchloride) (PVC) membrane selective electrode [8] , selective separation using bismuth silicate ion-exchanger [9] and chemiluminescence determination using luminol-diperiodatoargentate(III) [10] . A sensitive spectrophotometric method recently has been developed for the determination of isopropyl amine, a core moiety of isoproterenol hydrochloride, at the trace level in pharmaceutical drug substances [11] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, isolation, identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC, LC/ESI-MS and NMR

Kumar

Devineni

Gajjala

et al. 2017

Journal of Pharmaceutical Analysis

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One unknown impurity (Imp-II) during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-(propan-2-ylamino)ethyl]benzene-1,2-diol (Imp-II) using the liquid chromatography--mass spectrophotometry (LC--MS) analysis. Imp-II was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as 1H, 13C, DEPT (1D NMR), HSQC (2D NMR) and infrared spectroscopy (IR), and retention time and purity with HPLC followed by the chemical synthesis. Due to less removable nature of Imp-II during the purification, the synthetic process was optimized proficiently to control the formation of Imp-II below to the limit<0.12% in the course of reaction. The new chemical route was developed for the preparation of this impurity in required quantity with purity to use as reference standard. The most probable mechanism for the formation of Imp-II was discussed in details.

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A sensitive chemiluminescence determination of isoproterenol in pharmaceutical and human serum using luminol–diperiodatoargentate(iii) system

Cited by 10 publications

References 38 publications

Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample

Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample

Stability Indicating Method Development and Validation for the Quantification of Isoproterenol HCL in Bulk and Its Formulation by Rp-HPLC Using Pda Detection

Synthesis, isolation, identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC, LC/ESI-MS and NMR

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