A sensing interface for recognition of tryptophan enantiomers based on porous cluster-like nanocomposite films

Guo, Dongmei; Huang, Yihan; Cui, Chen; Ya, Chen; Fu, Yingzi

doi:10.1039/c4nj01484g

Cited by 51 publications

(32 citation statements)

References 44 publications

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“…The regression equation between ∆ E p and l -Trp% is expressed as ∆ E p = −0.9428 + 0.2148 × l -Trp% with a correlation coefficient of 0.9757. Such good chiral recognition ability is comparable to the best results reported previously [12,20]. …”

Section: Resultssupporting

confidence: 90%

“…As shown in Figure 8C, the DPV peak currents are linearly dependent on the concentrations of Trp enantiomers in the range of 5.0 × 10 − 6 M to 7.0× 10 − 5 M. As indicated in Figure 8C, two regression equations are concluded as I p = −1.073 − 1340[ d -Trp] with correlation coefficient of 0.9629 and I p = −0.1425 − 343.3[ l -Trp] with a correlation coefficient of 0.9816, respectively. The detection limits of d -Trp and l -Trp are 1.7 × 10 − 6 M and 4.4 × 10 − 6 M ( S / N = 3), respectively, which is comparable with the reported results [12]. These results demonstrated that N-CDs/β-CD nanocomposites modified GCE can be used in the chiral detection of Trp enantiomers.…”

Section: Resultssupporting

confidence: 89%

“…On the other side, as a non-protein amino acid, d -Tryptophan ( d -Trp) often presents different activity, toxicity and metabolic routes [12]. Therefore, it is necessary to distinguish between Trp enantiomers in the field of pharmaceuticals and biotechnology.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers

Xiao¹,

Lu²,

Huang³

et al. 2016

Sensors

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Based on N-doped carbon dots/β-cyclodextrin nanocomposites modified glassy carbon electrodes (N-CDs/β-CD/GCE), an effective electrochemical sensor for enantioselective recognition of tryptophan (Trp) enantiomers was developed by differential pulse voltammograms (DPVs). Fluorescent N-CDs were synthesized through a hydrothermal method and characterized by spectroscopic approaches. The N-CDs/β-CD nanocomposites were efficiently electrodeposited on the surface of GCE through C–N bond formation between N-CDs and electrode. The obtained N-CDs/β-CD/GCE was characterized by multispectroscopic and electrochemical methods. Such N-CDs/β-CD/GCE generated a significantly lower Ip and more negative Ep in the presence of l-Trp in DPVs, which was used for the enantioselective recognition of Trp enantiomers. The N-CDs/β-CD nanocomposites showed different binding constants for tryptophan enantiomers, and they further selectively bonded with l-Trp to form inclusion complexes. This N-CDs/β-CD/GCE combined advantages of N-CDs with strong C–N binding ability and β-CD with specific recognition of Trp enantiomers to fabricate a novel sensing platform for enantioselective recognition of Trp enantiomers. This strategy provided the possibility of using a nanostructured sensor to discriminate the chiral molecules in bio-electroanalytical applications.

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 89%

See 1 more Smart Citation

Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers

Xiao¹,

Lu²,

Huang³

et al. 2016

Sensors

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“…[18][19][20][21] Thus, the material in combination with MWCNTs and conductive polymer is promising for the detection of L-dopa. 22,23 Glutathione disulfide (GSSG) is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine. It can be electropolymerized on the surface of GCE to promote electron transfer.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Electrochemical Sensing Platform for the Detection of L-dopa Based on Electropolymerizing Glutathione Disulfide and Multi-walled Carbon Nanotube-modified Electrodes

Yang¹,

Zhu²,

Ma³

et al. 2018

S.Afr.j.chem.

Self Cite

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A facile sensing platform for the detection of L-dopa has been developed by electropolymerizing glutathione disulfide (PGSSG) on the surface of glass carbon electrodes (GCE) which were modified by multi-walled carbon nanotubes (MWCNTs). The electrochemical behaviour of the proposed electrodes were investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The morphology of the PGSSG and PGSSG/MWCNTs were characterized by scanning electron microscopy (SEM). Under the optimized experimental conditions, the sensing platform showed the linear response to L-Dopa in a range from 1.0 × 10-6 to 1.2 × 10-3 M with a detection limit of 3.3 × 10-7 M (S/N = 3). Moreover, with the merits of high sensitivity and selectivity, good stability and reproducibility, the sensor was successfully applied for the determination of L-dopa in a real sample.

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“…1 Chiral molecules have two enantiomeric forms which exhibit same chemical properties but have different biological properties because of the inherent chirality of biological systems. [2][3][4][5] Most biologically active molecules are chiral, including the naturally occurring amino acids (the building blocks of proteins) and sugars. Among them, ascorbic acid is an optically active chiral compound, having two forms which are ascorbic acid (AA) and isoascorbic acid (IAA).…”

Section: Introductionmentioning

confidence: 99%

Enantioselective recognition of ascorbic acid and isoascorbic acid on HS-β-cyclodextrin/gold nanoparticles/hollow carbon microspheres hybrid modified electrodes

Ying

Xia

et al. 2016

New J. Chem.

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aThe HS-β-cyclodextrin/gold nanoparticles/hollow carbon microspheres (HS-β-CD/AuNPs/HCMS) hybrids were successfully synthesized and characterized via scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), fourier transform infrared spectroscopy (FT-IR), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). A simple and reliable chiral sensing platform constructed by the prepared hybrids was used for enantioselective recognition of ascorbic acid (AA) and isoascorbic acid (IAA), moreover, the stereo selectivity of HS-β-CD/AuNPs/HCMS to AA or IAA was investigated via differential pulse voltammetry (DPV). The results showed that obvious difference of peak currents of AA and IAA was obtained, demonstrating this strategy could be employed to enantioselectively recognize AA and IAA. Under the optimum conditions, the chiral sensor exhibited an acceptable linear response to AA or IAA in a linear range of 1.0 × 10 −4 to 5.0 × 10 −3 M with a limit of detection of 1.7 × 10 −5 M (S/N = 3). This approach provided a new available sensing interface to recognize and determine AA or IAA by electrochemical technology.The HS-β-cyclodextrin/gold nanoparticles/hollow carbon microspheres hybrids were prepared to develop a simple strategy for electrochemical chiral analysis.

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A sensing interface for recognition of tryptophan enantiomers based on porous cluster-like nanocomposite films

Cited by 51 publications

References 44 publications

Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers

Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers

Highly Sensitive Electrochemical Sensing Platform for the Detection of L-dopa Based on Electropolymerizing Glutathione Disulfide and Multi-walled Carbon Nanotube-modified Electrodes

Enantioselective recognition of ascorbic acid and isoascorbic acid on HS-β-cyclodextrin/gold nanoparticles/hollow carbon microspheres hybrid modified electrodes

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