Highly Sensitive Electrochemical Sensing Platform for the Detection of L-dopa Based on Electropolymerizing Glutathione Disulfide and Multi-walled Carbon Nanotube-modified Electrodes

Abstract

A facile sensing platform for the detection of L-dopa has been developed by electropolymerizing glutathione disulfide (PGSSG) on the surface of glass carbon electrodes (GCE) which were modified by multi-walled carbon nanotubes (MWCNTs). The electrochemical behaviour of the proposed electrodes were investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The morphology of the PGSSG and PGSSG/MWCNTs were characterized by scanning electron microscopy (SEM). Under the optimized experimental conditions, the sensing platform showed the linear response to L-Dopa in a range from 1.0 × 10-6 to 1.2 × 10-3 M with a detection limit of 3.3 × 10-7 M (S/N = 3). Moreover, with the merits of high sensitivity and selectivity, good stability and reproducibility, the sensor was successfully applied for the determination of L-dopa in a real sample.

Simultaneous Electrochemical Determination of L-Dopa and Melatonin at Reduced Graphene Oxide-Cu0.5Co0.5Fe2O4Modified Platinum Electrode

“…Evidence suggests that the long term use of L-dopa produce cytotoxic effects like gastritis, paranoia dyskinesia etc. [10][11][12][13][14][15][16] The production of L-dopa and melatonin influence each other and they coexist in biological systems. Thus, the development of sensitive and reliable method for the simultaneous determination of L-dopa and melatonin is highly desirable.…”