A self-setting single-component calcium phosphate cement

Zoulgami, Mariam; Lucas, Anita; Briard, P.; Gaude, J.

doi:10.1016/s0142-9612(00)00384-7

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…As the result, both the initial and final compounds have the same Ca/P ionic ratio. Due to the fact, that only one calcium orthophosphate is used; the solid part of such formulations might be called as a single-phase (or single-component) cement powder [168]. Cements made of ACP + an aqueous solution [169,170], α-TCP + an aqueous solution [171][172][173][174][175][176][177][178], β-TCP + an aqueous solution [175,179], DCPA + an aqueous solution [24], CDHA + an aqueous solution [25], TTCP + an aqueous solution [26,180,181] or γ-radiated TTCP + an aqueous solution [182][183][184] The experimental details on TTCP hydrolysis under a near-constant composition condition might be found elsewhere [185].…”

Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…Among biocompatible materials like calcium carbonate [1][2][3][4][5][6][7], calcium phosphate [8][9][10][11], aluminosilicate (geopolymers) [12][13][14] and Bioglass 1 [15][16][17], some of them, known as bioactive, are able to form an apatite-like layer on their surfaces when in contact with simulated body fluid (SBF) in vitro [18][19][20][21] or with physiological fluid in vivo [8,22,23]. This apatite-like layer, associated with bioreactivity [22], is speculated to be responsible for bone bonding [16,23].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the surface reactivity of a sol–gel derived glass in the ternary system SiO2–CaO–P2O5

Mami

Lucas‐Girot

Oudadesse

et al. 2008

Applied Surface Science

104

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“…As the result, both the initial components and final products have the same Ca/P ionic ratio. Due to the fact, that only one calcium orthophosphate is used; the solid part of such formulations might be called as a single-phase (or single-component) cement powder [192]. Self-setting formulations made of ACP + an aqueous solution [193,194], α-TCP + an aqueous solution [23,24,27,[195][196][197][198][199][200][201][202][203], β-TCP + an aqueous solution [199,204], DCPA + an aqueous solution [40], CDHA + an aqueous solution [41], OCP + an aqueous solution [42], TTCP + an aqueous solution [43,205,206] or γ-radiated TTCP + an aqueous solution [207][208][209] are the typical examples; the majority of them are re-crystallized to CDHA during setting: (6) As seen from the amount of publications, α-TCP is the most popular compound to produce self-setting single-phase calcium orthophosphate formulations.…”

Section: General Information and Knowledgementioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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A self-setting single-component calcium phosphate cement

Cited by 16 publications

References 16 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Investigation of the surface reactivity of a sol–gel derived glass in the ternary system SiO2–CaO–P2O5

Self-Setting Calcium Orthophosphate Formulations

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