A self-guidance biological hybrid drug delivery system driven by anaerobes to inhibit the proliferation and metastasis of colon cancer

Zhang, Huijuan; Wang, Yaping; Li, Mengting; Cao, Kexuan; Qi, Zijun; Zhu, Ling; Zhang, Zhenzhong; Hou, Lin

doi:10.1016/j.ajps.2022.09.003

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Bacteria-based drug delivery systems are used because microorganisms evolve to exhibit special biological functions (kinetic properties 9 and anaerobic site targeting 10 ). However, the microorganisms also have disadvantages such as the risk of possible pathogenicity, the inevitable rapid growth rate of bacteria under physiological conditions, and even their potential antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Applications of microalga-powered microrobots in targeted drug delivery

Zhou,

Yin,

Zhao

et al. 2023

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Applications of microalga-powered microrobots in targeted drug delivery

Zhou,

Yin,

Zhao

et al. 2023

Biomater. Sci.

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“…We have previously confirmed that drug-loaded nanoparticles (NPs) can bind to Bifidobacterium infantis ( B. infantis , Bif) to form a biohybrid for targeted tumor treatment [ 32 , 33 ]. B. infantis (Bif), which is a harmless anaerobic probiotic with no apparent toxic side effects and excellent targeting abilities [ 34 , 35 ], is thus considered an ideal therapy vector for treating different types of solid tumors [ 36 ]. However, due to the limited penetration depth of NIR light, NPs-mediated PTT is only effective against primary tumors, and tumors outside the range of laser irradiation are not completely eliminated.…”

Section: Introductionmentioning

confidence: 99%

GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model

Dai,

Li,

Zhang

et al. 2023

Biomater Res

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Background Hypoxia is a frequent characteristic observed in solid tumors and is strongly associated with tumor metastasis, angiogenesis, and drug resistance. While the vasculature of hypoxic tumor tissues poses obstacles to the efficient administration of conventional drugs, it may prove advantageous in sustaining hyperthermia. Photothermal therapy (PTT) offers a promising treatment strategy that utilizes the activation of photosensitizers to produce heat, thus facilitating the selective ablation of tumor tissues. Method To enhance the accumulation of photothermal agents in tumor tissue and improve the effectiveness of PTT, we developed a self-propelled hybrid called Bif@PAu-NPs. This hybrid consists of polydopamine (PDA)-coated gold nanoparticles (Au-NPs) loaded onto the anaerobic Bifidobacterium infantis (Bif). Results The Bif@PAu-NPs actively aggregated at the tumor site because the ability of Bif can target hypoxic regions, and PAu-NPs achieved precise PTT due to their high photothermal conversion efficiency (η = 67.8%). The tumor tissues were ablated by PTT, resulting in the release of antigens through immunogenic cell death (ICD), which stimulates an immune response. The inclusion of GM-CSF enhanced the immune response by recruiting dendritic cells and initiating long-term anti-tumor immunity. Conclusion The Bif@PAu-NPs hybrid effectively suppressed the growth of both primary tumors and re-challenged tumors. The utilization Bif@PAu-NPs in conjunction with GM-SCF exhibits great potential as a photothermal-immunotherapeutic strategy for precisely treating solid tumors. Graphical Abstract In this study, the bacterial Bif@PAu-NPs biohybrid is exploited the self-driving ability of anaerobic Bifidobacterium infantis to deliver polydopamine-modified gold nanoparticles to hypoxic region of tumor. Under irradiation with 808 nm NIR laser, the hybrid exerts precise photothermal therapy to stimulate the immune response, which is further enhanced by GM-CSF, leading to recruitment of dendritic cells and initiation of a long-term anti-tumor immunity remember to prevent tumor recurrence.

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