A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action

Dowling, Matthew B.; Kumar, Rakesh; Keibler, Mark A.; Hess, John R.; Bochicchio, Grant V.; Raghavan, Srinivasa R.

doi:10.1016/j.biomaterials.2010.12.033

Cited by 213 publications

(244 citation statements)

References 29 publications

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“…Dowling and colleagues developed a chitosan-based amphiphilic biopolymer that exhibits clotting ability in the presence of blood by self-assembly that is readily reversible by introducing a sugar-based supramolecule [ 108 ] . First, chitosan was hydrophobically modifi ed by attaching a small number of hydrophobic tails to the backbone (hm-chitosan).…”

Section: Chitosan-based Sealantmentioning

confidence: 99%

Sealants (Adhesives) to Prevent Bleeding

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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In general, surgical sealants (adhesives) are liquids and form gels when applied. Currently, several products are clinically available, including naturally derived fi brin sealants, semisynthetic products such as gelatin and albumin-based glues, and synthetic products including cyanoacrylates and poly(ethylene glycol). These products, however, have both advantages and disadvantages. While fi brin sealants have been successfully used in many surgical fi elds, they have several disadvantages including low adhesive strength. Other products, such as cyanoacrylates and protein-based products, have high adhesion strength but have high toxicity, and therefore, their applications are limited. Studies are still ongoing in order to develop sealants with higher adhesion strength and safer properties compared to the sealants that are currently available. This chapter reviews the chemistry and applications of clinically available sealants and recent developments in this fi eld.

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Section: Chitosan-based Sealantmentioning

confidence: 99%

Sealants (Adhesives) to Prevent Bleeding

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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“…On the other hand, Mo et al [71] developed a 16-arm polypropylenimine hexadecaamine dendrimer conjugated to a PEG derivative capped with hydrophobic oleoyl groups to accomplish rapid construction of multicellular structures of hepatic cells (figure 7). Lee et al [72] reported on hydrophobically modified chitosan (hm-chitosan) and its biomedical applications [73]. They applied hm-chitosan as a hemostatic agent and found that it coagulated blood even in the presence of heparin.…”

Section: Hydrophobic Interactionmentioning

confidence: 99%

Assembly of cells and vesicles for organ engineering

Taguchi

2011

Science and Technology of Advanced Materials

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The development of materials and technologies for the assembly of cells and/or vesicles is a key for the next generation of tissue engineering. Since the introduction of the tissue engineering concept in 1993, various types of scaffolds have been developed for the regeneration of connective tissues in vitro and in vivo. Cartilage, bone and skin have been successfully regenerated in vitro, and these regenerated tissues have been applied clinically. However, organs such as the liver and pancreas constitute numerous cell types, contain small amounts of extracellular matrix, and are highly vascularized. Therefore, organ engineering will require the assembly of cells and/or vesicles. In particular, adhesion between cells/vesicles will be required for regeneration of organs in vitro. This review introduces and discusses the key technologies and materials for the assembly of cells/vesicles for organ regeneration.

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“…For these reasons, heparin and heparan sulfate have been investigated as constituents for selfassembling nanoparticle delivery systems for growth factors and other drugs. Chitosan and heparin have both shown promise as particle constituents for wound healing applications [59,60]. In a recent study, Tang et al [58] prepared pH-responsive heparinized chitosan-poly(γ-glutamic acid) polyelectrolyte complex nanoparticles that encapsulated bFGF.…”

Section: Chitosan and Heparin-based Nanoparticles For Bfgf Deliverymentioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

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Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

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A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action

Cited by 213 publications

References 29 publications

Sealants (Adhesives) to Prevent Bleeding

Sealants (Adhesives) to Prevent Bleeding

Assembly of cells and vesicles for organ engineering

Self-assembled polysaccharide nanostructures for controlled-release applications

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