A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence

Burton‐Freeman, Britt; Brzeziński, Michał; Park, Eunyoung; Sandhu, Amandeep; Xiao, Di; Edirisinghe, Indika

doi:10.3390/nu11040841

Cited by 68 publications

(64 citation statements)

References 123 publications

(158 reference statements)

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“…Parkinson's disease progression in men is also less likely with higher dietary flavonoid consumption [36]. Recently, anthocyanins and flavan-3-ols have been shown to reduce the risk of type II diabetes mellitus [37]. In addition, interest in the interaction of flavonoids with gut microbiota is increasing [38].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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A large number of diverse mechanisms that lead to cytoprotection have been described to date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In addition to being metabolic centers, due to their role in cell catabolism, ATP synthesis, and biosynthesis these organelles are triggers and/or end-effectors of a large number of signaling pathways. Their role in the regulation of the intrinsic apoptotic pathway, calcium homeostasis, and reactive oxygen species signaling is well documented. In this review, we aim to characterize the prospects of influencing cytoprotective mitochondrial signaling routes by natural substances of plant origin, namely, flavonoids (e.g., flavanones, flavones, flavonols, flavan-3-ols, anthocyanidins, and isoflavones). Flavonoids are a family of widely distributed plant secondary metabolites known for their beneficial effects on human health and are widely applied in traditional medicine. Their pharmacological characteristics include antioxidative, anticarcinogenic, anti-inflammatory, antibacterial, and antidiabetic properties. Here, we focus on presenting mitochondria-mediated cytoprotection against various insults. Thus, the role of flavonoids as antioxidants and modulators of antioxidant cellular response, apoptosis, mitochondrial biogenesis, autophagy, and fission and fusion is reported. Finally, an emerging field of flavonoid-mediated changes in the activity of mitochondrial ion channels and their role in cytoprotection is outlined.

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Section: Introductionmentioning

confidence: 99%

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Kicińska

Jarmuszkiewicz

2020

Molecules

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“…For this reason, there is much interest in these compounds as potential anti-diabetic drugs. This is reflected in the large number of in vitro and in vivo studies carried out to assess the effect of flavonoids in the context of diabetes [48][49][50].…”

Section: Recent Preclinical Advances In the Anti-diabetic Actions Of mentioning

confidence: 99%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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“…Polyphenols categorized as flavonoids, phenolic acid, stilbenes, and lignans are abundantly present in fruits, vegetables, and other plant‐derived products (Rodriguez‐Garcia, Sanchez‐Quesada, Toledo, Delgado‐Rodriguez, & Gaforio, ). The antioxidant and anti‐inflammatory properties of these agents (Scalbert, Johnson, & Saltmarsh, ) might be responsible for their beneficial effects in different disease conditions like diabetes (Burton‐Freeman et al, ), cancer (Mileo, Nistico, & Miccadei, ), inflammation (Johnson et al, ), cardiovascular diseases (Poloni, Dangles, & Vinson, ), autoimmune (Khan et al, ), and neurological disorders (Ethemoglu et al, ). Besides their antioxidant and anti‐inflammatory effects, these molecules equally possess signal transduction properties via interaction with the receptors or enzymes (Kennedy, ).…”

Section: Introductionmentioning

confidence: 99%

Natural polyphenols in preclinical models of epilepsy

Dhir

2020

Phytotherapy Research

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Natural polyphenols are being tested both in preclinical and clinical settings for the treatment of different neurological disorders. The article describes the outcome of three polyphenols, resveratrol, epigallocatechin gallate, and quercetin, in preclinical animal models of epilepsy (both acute and chronic) and epileptogenesis. In theory, the antioxidant and neuroprotective properties of these natural polyphenols might be valuable in the management of acute seizures and the prevention of epileptogenesis. It is fascinating to observe that these polyphenols have a capacity to alter various signaling processes involved in the pathogenesis of epilepsy. The antiepileptic or antiseizure potential with these molecules delivers a mixed outcome.Some studies have demonstrated the usefulness of these molecules in preclinical models of epilepsy; however, contrary to the findings also exist. These molecules have poor bioavailability that may remain as the limiting factor in their clinical effects.The use of nanotechnology and other techniques have been tested to enhance bioavailability and brain penetration. There are no randomized double-blinded clinical studies establishing their antiepileptic effects in humans. It is concluded that more preclinical mechanism-based studies are needed to deliver a more certain picture regarding the use of natural polyphenols in the treatment of epilepsy. K E Y W O R D Sbioavailability, blood brain barrier penetrability, epigallocatechin, epilepsy, epileptogenesis, nanotechnology, polyphenols, quercetin, resveratrol

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A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence

Cited by 68 publications

References 123 publications

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Natural polyphenols in preclinical models of epilepsy

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