Natural polyphenols in preclinical models of epilepsy

Abstract

Natural polyphenols are being tested both in preclinical and clinical settings for the treatment of different neurological disorders. The article describes the outcome of three polyphenols, resveratrol, epigallocatechin gallate, and quercetin, in preclinical animal models of epilepsy (both acute and chronic) and epileptogenesis. In theory, the antioxidant and neuroprotective properties of these natural polyphenols might be valuable in the management of acute seizures and the prevention of epileptogenesis. It is fascinating to observe that these polyphenols have a capacity to alter various signaling processes involved in the pathogenesis of epilepsy. The antiepileptic or antiseizure potential with these molecules delivers a mixed outcome.Some studies have demonstrated the usefulness of these molecules in preclinical models of epilepsy; however, contrary to the findings also exist. These molecules have poor bioavailability that may remain as the limiting factor in their clinical effects.The use of nanotechnology and other techniques have been tested to enhance bioavailability and brain penetration. There are no randomized double-blinded clinical studies establishing their antiepileptic effects in humans. It is concluded that more preclinical mechanism-based studies are needed to deliver a more certain picture regarding the use of natural polyphenols in the treatment of epilepsy. K E Y W O R D Sbioavailability, blood brain barrier penetrability, epigallocatechin, epilepsy, epileptogenesis, nanotechnology, polyphenols, quercetin, resveratrol

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

“…In recent decades, the search for natural sources of biologically active substances has become highly acute despite the large number of synthetic drugs used in modern medicine [1,2]. It is known that the use of herbal drugs is explained not only by their high biological activity, but also by the absence of adverse reactions inherent in synthetic drugs [3,4].…”

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

“…Recently, compounds found in plant products have received large interest in the development of new treatments against epilepsy (Pina et al, 2022; Schachter, 2009; Sucher & Carles, 2015). Among these compounds, stilbenes (e.g., resveratrol, pterostilbene, and piceatannol) are known to have beneficial effects in preclinical models of seizures and epilepsy (Dhir, 2020).…”

Resveratrol inhibits nicotine-induced conditioned place preference in mice

“…Pharmacological effects described for resveratrol include antiepileptic, anti-inf lammatory, antioxidant, anti-tumorigenic, neuroprotective, and hypertensive activities (Repossi, Das, Eynard, 2020;Tian, Liu, 2020). A series of recent studies show that resveratrol displays multiple effects on the central nervous system, such as antidepressant, anticonvulsant, anti-neurodegenerative, antinociceptive, anxiolytic, and sedative effects (Dhir, 2020;Repossi, Das, Eynard, 2020;Singh et al, 2019). Treatment with resveratrol was well tolerated, without severe adverse events, and with no treatment-related effects (Repossi, Das, Eynard, 2020).…”