A selected review of the literature and an empirical analysis of drug treatment compliance by schizophrenic patients

Pool, Vaira Eve; Elder, S. Thomas

doi:10.1111/j.1464-0597.1986.tb00959.x

Cited by 15 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies of Fitch et al and Huang et al, may explain this finding, which reported younger individuals constituting more inpatient visits compared to older individuals due to poor medication adherence. [ 2 , 21 ] Early medication nonadherence was found to be a predictor of poor drug adherence that leads to the pattern of disease relapse and hospitalization that is sustained throughout an individual's life, [ 39 , 40 ] which may explain the up-trending hospitalization rate for all standardized age groups. Furthermore, the decrease in hospitalization rate from younger to older age groups in every observed year could be due to low adherence in younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia hospitalization in the US 2005–2014

et al. 2021

View full text Add to dashboard Cite

Primarily we aimed to examine the crude and standardized schizophrenia hospitalization trend from 2005 to 2014. We hypothesized that there will be a statistically significant linear trend in hospitalization rates for schizophrenia from 2005 to 2014. Secondarily we also examined trends in hospitalization by race/ethnicity, age, gender, as well as trends in hospitalization Length of Stay (LOS) and inflation adjusted cost. In this observational study, we used Nationwide Inpatient Sample data and International Classification of Diseases, Eleventh Revisions codes for Schizophrenia, which revealed 6,122,284 cases for this study. Outcomes included crude and standardized hospitalization rates, race/ethnicity, age, cost, and LOS. The analysis included descriptive statistics, indirect standardization, Rao-Scott Chi-Square test, t -test, and adjusted linear regression trend. Hospitalizations were most prevalent for individuals ages 45–64 (38.8%), African Americans were overrepresented (25.8% of hospitalizations), and the gender distribution was nearly equivalent. Mean LOS was 9.08 days (95% confidence interval 8.71–9.45). Medicare was the primary payer for most hospitalizations (55.4%), with most of the costs ranging from $10,000-$49,999 (57.1%). The crude hospitalization rates ranged from 790–1142/100,000 admissions, while the US 2010 census standardized rates were 380–552/100,000 from 2005–2014. Linear regression trend analysis showed no significant difference in trend for race/ethnicity, age, nor gender ( P > .001). The hospitalizations’ overall rates increased while LOS significantly decreased, while hospitalization costs and Charlson's co-morbidity index increased ( P < .001). From 2005–2014, the overall US hospitalization rates significantly increased. Over this period, observed disparities in hospitalizations for middle-aged and African Americans were unchanged, and LOS has gone down while costs have gone up. Further studies addressing the important disparities in race/ethnicity and age and reducing costs of acute hospitalization are needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Schizophrenia hospitalization in the US 2005–2014

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The HBM hypothesizes that a person will generally not attempt to address a condition or illness unless they perceive themselves as potentially vulnerable to the condition, which must be threatening, and are convinced of the bene ts of treatment. A number of authors have shown the importance of the HBM in explaining compliance in medical settings (Adam & Howe, 1993;Chan, 1984;Pool & Elder, 1986).…”

Section: Psychosocial Factorsmentioning

confidence: 99%

Exploring the Complexity of Compliance in Schizophrenia

Pinikahana

Happell

Taylor

et al. 2002

Issues in Mental Health Nursing

View full text Add to dashboard Cite

A large body of literature indicates that people diagnosed with schizophrenia are highly likely to not comply with their prescribed treatment regime at some stage during the illness process. Factors that indicate the risk of noncompliance have been the subject of considerable research over a number of years. This paper presents an extensive review of the research literature on the subject of compliance in schizophrenia. A number of factors have constituted the focus of research into this area. These include: socio-demographic characteristics, including age, gender and socioeconomic status; illness factors including insight, psychiatric symptomatology, duration of illness, substance abuse, and adverse side-effects of medication; psychosocial factors such as health beliefs and social supports; and treatment factors including the nature of the therapeutic relationship between patients and health care professionals. While the results of relevant research do not provide a clear and conclusive picture of compliance, they provide important information to guide the pivotal role of the mental health nurse in facilitating patient compliance.

show abstract

“…Nonadherence to the treatment in schizophrenia has been shown to be the most important cause for relapse and readmission to the hospital. [ 8 ] Nonadherence can lead up to four to five time's higher chances of patients with schizophrenia to relapse. [ 9 ] Nonadherence has also been shown to be associated with increased rates of involuntary admissions, slower recovery and longer hospital stay,[ 10 ] higher risk of suicide,[ 11 ] poorer prognosis,[ 12 ] and low satisfaction with life.…”

mentioning

confidence: 99%

Evaluation of treatment adherence in outpatients with schizophrenia

et al. 2017

View full text Add to dashboard Cite

Background:Treatment nonadherence is a major obstacle in the successful management of schizophrenia. Finding out factors associated with nonadherence and the reasons for nonadherence are important to improve treatment adherence in patients with schizophrenia. This study was conceived to evaluate treatment adherence in patients with schizophrenia and the factors associated with it.Materials and Methods:A cross-sectional study was conducted in 50 consecutive patients with schizophrenia with the help of semi-structured pro forma consisting of sociodemographic details, information regarding illness and treatment history, (PANSS), and Morisky Medication Adherence Scale-8 to assess medication adherence. Nonadherent patients were further assessed for their reasons for nonadherence.Results:Among the patients, 52% were low adherers (nonadherers). Factors associated with nonadherence were younger age of patients, male gender, low household income, higher PANSS score (positive, negative, and total score), lower grades of insight, lack of family history of psychiatric illness, responsibility of taking self-medications, first-generation antipsychotics, and number of drugs in prescription. Major reason for nonadherence given by patients were adverse effects of medications, treatment perceived as ineffective, financial problems, shame and stigma about illness and treatment, regarding treatment unnecessary and difficulty to access health-care facility.Conclusion:Our study established high proportion of nonadherence in patients with schizophrenia and also brought out factors associated and reasons for nonadherence. Adequate psychoeducation of patients and their caretakers as well as psychosocial interventions, strengthening mental health infrastructure, and community mental health services will significantly improve treatment adherence.

show abstract

A selected review of the literature and an empirical analysis of drug treatment compliance by schizophrenic patients

Cited by 15 publications

References 44 publications

Schizophrenia hospitalization in the US 2005–2014

Schizophrenia hospitalization in the US 2005–2014

Exploring the Complexity of Compliance in Schizophrenia

Evaluation of treatment adherence in outpatients with schizophrenia

Contact Info

Product

Resources

About