A SEER Database Analysis of Urethral Cancer Management

Zhang, C.; Wang, S.; Deutsch, Israel

doi:10.1016/j.ijrobp.2012.07.1124

Cited by 3 publications

(2 citation statements)

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“…After reviewing the titles, abstracts and full texts, we selected 92 studies for qualitative synthesis (Fig. 1) [1,2,4–6,8–95].…”

Section: Resultsmentioning

confidence: 99%

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

García‐Perdomo,

Dávila‐Raigoza,

Summers

et al. 2024

BJU International

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ObjectiveTo determine the effectiveness and adverse effects of urethrectomy alone or as part of multimodal therapy (MMT).MethodsA comprehensive search was conducted across MEDLINE (OVID), EMBASE, LILACS and the Cochrane Central Register of Controlled Trials (CENTRAL) databases, from their inception to the present date. The study cohort comprised individuals aged 16 years and older diagnosed with urethral tumours at any stage who underwent either isolated urethrectomy or urethrectomy as an integral component of MMT.ResultsNinety‐two studies comprising 25 480 patients met the inclusion criteria. Surgical outcomes for urethral cancer vary considerably, with 5‐year overall survival (OS) ranging from 10% to 68% based on disease extent, approach, and gender. Radiotherapy (RT) alone provides 5‐year OS of approximately 40%. Combined regimens provide better outcomes compared to single modalities, including reduced recurrence and enhanced survival. However, trimodal therapy showed survival benefits only for urothelial subtypes, indicating the need to tailor management according to cancer type. MMT with neoadjuvant chemotherapy prior to surgery demonstrated the most consistent survival gains.ConclusionsThe management of urethral cancer demands a nuanced, personalised approach, accounting for factors such as tumour location, sex, and tumour stage. MMT combining surgery, chemotherapy and RT has shown the ability to enhance outcomes in advanced disease. More extensive collaborative studies through specialised centres are imperative to advance evidence‐based protocols and refine treatment in order to improve survival.

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“…After reviewing the titles, abstracts and full texts, we selected 92 studies for qualitative synthesis (Fig. 1) [1,2,4–6,8–95].…”

Section: Resultsmentioning

confidence: 99%

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

García‐Perdomo,

Dávila‐Raigoza,

Summers

et al. 2024

BJU International

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“…Urethral carcinomas histopathologically fall into three main morphologies: transitional cell carcinoma (TCC), squamous cell carcinoma (SCC) or adenocarcinoma (AC) in order of prevalence. TCCs comprise 54‐62% diagnoses, followed by SCC (16‐22%) and AC (10‐16%) …”

Section: Introductionmentioning

confidence: 99%

A Case study of the radiation therapy treatment of a transitional cell carcinoma of the distal urethra

Donovan

Beldham‐Collins

Turner

2020

J of Medical Radiation Sci

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Urethral carcinoma is a rare urological cancer, accounting for only 1% of malignancies in Australia. The most common histology is transitional cell carcinoma (TCC). The majority of these cancers are treated with surgery. The main purpose of this case study is to describe a novel radiation treatment technique for treatment of this uncommon cancer. This report details organpreserving treatment for a distal penile urethral cancer using definitive radiation therapy (RT). In May 2016 a 69-year-old male presented to Crown Princess Mary Cancer Centre (CPMCC) with a small TCC of the distal urethra. The patient was offered numerous treatment options, both radical and organ-preserving approaches, and came to a final decision of a course of radiation therapy despite the lack of randomised evidence to guide treatment in this setting. A dose of 66 Gy in 33 fractions from parallel opposed lateral beams was prescribed to the distal penile urethra. This case required an unusual approach to patient set up to allow access for accurate treatment delivery and to maintain patient comfort. The patient tolerated the full course of radiation therapy with expected skin side effects. He has maintained adequate penile function and is currently free from disease at 33 months with ongoing clinical follow-up.

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Multimodal management of primary adenocarcinoma of the female urethra: About four cases

Deberne

Timsit

Verkarre

et al. 2016

Cancer/Radiothérapie

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A SEER Database Analysis of Urethral Cancer Management

Cited by 3 publications

References 0 publications

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours

A Case study of the radiation therapy treatment of a transitional cell carcinoma of the distal urethra

Multimodal management of primary adenocarcinoma of the female urethra: About four cases

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