Multimodal management of primary adenocarcinoma of the female urethra: About four cases

Deberne, M.; Timsit, Marc Olivier; Verkarre, V.; Eiss, D.; Kreps, S.; Housset, M.

doi:10.1016/j.canrad.2015.11.005

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…The need for multimodal therapy including chemotherapy, radiotherapy, and surgery in contemporary management of PUC, especially for advanced disease, has been well described, although the ideal combination is more contested. [ 21 22 23 ] According to the international collaboration on PUC, in analyzing 124 patients at ten centers undergoing a number of treatment combinations, neoadjuvant chemotherapy may provide a benefit to advanced disease. [ 24 ] Limitations in our study include possible coding discrepancies, including UC extending from the bladder neck that may be coded as PUC, although efforts were made to exclude codes for bladder and bladder neck pathologies.…”

Section: Discussionmentioning

confidence: 99%

Primary urethral carcinoma: A Surveillance, Epidemiology, and End Results data analysis identifying predictors of cancer-specific survival

et al. 2018

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Objectives:Primary urethral carcinoma (PUC) is rare, accounting for <1% of genitourinary malignancies. Current knowledge regarding is founded upon tertiary care centers reporting their experiences. We aim to identify factors predictive of outcomes using a nationwide registry database.Materials and Methods:The Surveillance, Epidemiology, and End Results-18 registries database was queried for cases of PUC ranging between 2004 and 2010. To identify PUC cases, ICD-O site code C68.0 was used as a filter, hence identifying PUC with histologic subtypes including urothelial carcinoma (UC), squamous cell carcinoma (SCC), and adenocarcinoma (AC). Tumor characteristics were compared using log-rank analysis, and survival outcomes were compared using Cox proportional hazards models.Results:A total of 419 PUC cases were identified, 250 (59.7%) male and 169 (40.3%) female patients. The most common histology in men was UC (134, 53.6%), followed by SCC (87, 34.8%) and AC (29, 11.6%). The most common histology in women was AC (79, 46.7%), followed by SCC (43, 25.4%) and UC (42, 24.9%). Log-rank analysis illustrated significant difference in cancer-specific survival (CSS) for T-stage, N-stage, M-stage, and stage of PUC with all histological variants combined (P < 0.001). Multivariate Cox proportional hazards model demonstrated that stage and age were significant for survival, with a risk ratio of 1.033 (95% confidence interval [CI], 1.020–1.046)/year of increased age (P < 0.001) and 3.71 (95% CI, 2.72–5.05) for patients with regional or distant spread.Conclusions:Knowledge of patient and tumor characteristics that influences survival is paramount in dictating management. The present study illustrates that age and stage are factors significantly associated with CSS in PUC.

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Section: Discussionmentioning

confidence: 99%

Primary urethral carcinoma: A Surveillance, Epidemiology, and End Results data analysis identifying predictors of cancer-specific survival

et al. 2018

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“…Adenocarcinoma of the distal urethra easily metastasizes to inguinal lymph nodes proximal to pelvic lymph nodes ( 27 ). Urethral adenocarcinoma, which is prone to metastasis ( 28 ), has a high recurrence rate ( 8 , 29 ). Our case had metastasis to the vulvar and inguinal lymph nodes, pelvic lymph nodes, and para-aortic lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous Carcinoma of Skene’s Gland: A Case Report and Literature Review

Gao

Liu

et al. 2022

Front. Oncol.

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Skene’s gland is homologous to the male prostate and can secrete prostate fluid. However, Skene’s gland carcinoma is extremely rare, with only 20 cases reported in the literature thus far. We report the first case of adenosquamous carcinoma of Skene’s gland. The patient was a 54-year-old woman who was admitted to our hospital due to vaginal bleeding and a vaginal mass, accompanied by multiple lymph nodes and vulvar metastases. She had a history of dysuria and episodic hematuria for 2 years. Contrast-enhanced pelvic MRI showed a mass in the right labia majora and swelling of the right inguinal lymph nodes. In addition, a mass in the anterior vaginal wall surrounded the urethra and grew in a semi-encircled manner. After receiving neoadjuvant chemotherapy, MRI revealed that the mass surrounding the urethra had shrunk, and the nodular shadow of the right labia majora was larger than before. The patient underwent elective surgery. Surgical pathology showed adenosquamous carcinoma, and immunohistochemistry suggested intestinal differentiation. Forty-six days after surgery, the patient subsequently died of tumor consumption and organ insufficiency due to cerebral infarction, recurrence, and multiple metastases. This paper describes the clinical, radiological, and histopathologic features as well as the prognosis of the rare disease adenosquamous carcinoma of Skene’s gland. In addition, we briefly review the published literature.

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