A Second Example of Lu(-6) in the Lutheran System

Wrobel, D.M.; Moore, B.P.L.; Cornwall, Sheila; Wray, Elizabeth; Øyen, Ragnhild; Marsh, W.L.

doi:10.1159/000466542

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Absorption With Lu(a-b-) Red Cells Dominant Inheritance Type1

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1973

2002

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Cited by 6 publications

(6 citation statements)

References 2 publications

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“…She had never been transfused. Her cells and serum were mutually compatible with those of the previous two makers [1,3] of anti-Lu6. The Lutheran reactions of Mrs. J. R. J. and of available relatives are given in table I where there are several surprises.…”

supporting

confidence: 77%

Weak Lu9 Antigen in One Lu:-6 Member of a Family

Dybkjaer¹,

Lylloff²,

Tippett³

1974

Vox Sanguinis

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supporting

confidence: 77%

Weak Lu9 Antigen in One Lu:-6 Member of a Family

Dybkjaer¹,

Lylloff²,

Tippett³

1974

Vox Sanguinis

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“…Lutheran antigens are not well developed on the red cells of newborn infants [3,4,10]. This characteristic was particularly striking in tests with anti-Lu 11.…”

Section: Absorption With Lu(a-b-) Red Cells Dominant Inheritance Typementioning

confidence: 98%

Anti-Lu 11: Another Antibody Defining a High-Frequency Antigen Related to the Lutheran Blood Group System

Gralnik¹,

Goldfinger²,

Hatfield³

et al. 1974

Vox Sanguinis

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“…Their structure includes five extracellular immunoglobulin superfamily domains, and they may have a role in the regulation of erythropoiesis and may also contribute to the adhesiveness of sickle RBCs 1 . Lu6 is a high‐incidence antigen within the Lu blood group system 2 . Anti‐Lu6 is detected rarely and only five examples of anti‐Lu6 have been reported in detail, 3‐6 although there are at least another five known cases 7 .…”

mentioning

confidence: 99%

The rare Lu:–6 phenotype in Israel and the clinical significance of anti‐Lu6

et al. 2002

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BACKGROUND: Lu6 is a high‐incidence antigen of the Lutheran blood group. Examples of anti‐Lu6 are rare and are of uncertain clinical significance. CASE REPORT: Three patients were encountered in whom anti‐Lu6 was detected on pretransfusion screening. The patients were all Iranian Jews and were not known to be related. In vitro studies to ascertain the potential clinical significance of the antibody using the monocyte monolayer assay (MMA) were negative in two patients. The third patient received a two‐unit transfusion of incompatible Lu6 RBCs with no signs of hemolysis. However, after the transfusion, the MMA and a chemiluminescence test were positive, whereas a chromium survival study was normal. Thus, the antibody may have changed in its clinical significance. CONCLUSION: Although anti‐Lu6 does not appear to be a clinically significant RBC antibody in all circumstances, transfusion of Lu6 RBCs in patients with anti‐Lu6 should be performed cautiously.

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A Second Example of Lu(-6) in the Lutheran System

Cited by 6 publications

References 2 publications

Weak Lu9 Antigen in One Lu:-6 Member of a Family

Weak Lu9 Antigen in One Lu:-6 Member of a Family

Anti-Lu 11: Another Antibody Defining a High-Frequency Antigen Related to the Lutheran Blood Group System

The rare Lu:–6 phenotype in Israel and the clinical significance of anti‐Lu6

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