A Search for Cancer-Testis Genes Expression in Blood and Biopsy of Patients With Colorectal Cancer

Викторович, Голышко Павел; Новиков, Д. В.; Ананьев, С В; Барышников, К А; Novikov, V. V.

doi:10.17650/1726-9784-2015-14-1-19-24

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Presently, the discovered 276 C/T antigens are united in 138 families, 7 of which are welldescribed and studied (MAGE-A, -B, BAGE, GAGE, SSX, LAGE, MAGE-C) [5]. Polypeptides CTA in combination with HLA1 (Human Leukocyte Antigens 1, molecules of the major histocompatibility complex (MHC) of class II) or HLA2 (Human Leukocyte Antigens 2, molecules of the major histocompatibility complex (MHC) of class II) appear in the immune system, which causes cytotoxic and humoral responses [6]. Each type of tumor tissue has a highly-specific profile of C/T gene expression.…”

Section: Introductionmentioning

confidence: 99%

Type I and Ii Collagens in Breast Tumours

Zhurakovsky¹,

Архипов²,

Arkhipova³

et al. 2019

MPSES

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Section: Introductionmentioning

confidence: 99%

Type I and Ii Collagens in Breast Tumours

Zhurakovsky¹,

Архипов²,

Arkhipova³

et al. 2019

MPSES

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Immunogenic Cancer-Testis Antigens and Their Genes in Malignant Tumors

Golyshko¹,

Барышников²,

Baryshnikov³

2015

Rossijskij bioterapevtičeskij žurnal

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The analysis of CTG and CTA expression in malignant tumors described in this review has been showed that different types of tumors are significantly different from each other according to the frequency of CTA mRNA expression. Melanoma, ovarian cancer and lung cancer have a very high frequency of CTA expression. Lymphoma, kidney cancer, pancreatic cancer have a low frequency of CTA expression. Breast cancer, bladder cancer, prostate cancer demonstrate an intermediate level of CTA expression. High degree malignant tumors in late clinical stage with metastases showed a greater incidence of CTA -gene expression. CTA-genes are expressed together in tumor. If the tumor is positive for one CTA-gene then the expression of several genes is possible. Immunogenic CTA-s are a well object for anti-tumor vaccines creating.

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mRNA of the <i>OY-TES-1</i> gene in peripheral blood and tumors in colorectal cancer

Hilal,

Novikov,

Yakimov

et al. 2023

Rossijskij bioterapevtičeskij žurnal

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Background. One of the testicular cancer genes is the OY-TES-1 gene, which encodes a proacrosin-binding protein. This gene is known to be expressed in tumor cells.Aim. To determinate the detection frequency of OY-TES-1 matrix ribonucleic acid (mRNA) in the peripheral blood and tumor of patients with colorectal cancer (CRC) in comparison with the clinical features of the course of a disease in order to assess the potential monitoring significance of this indicator.Materials and methods. A method for determining the level of OY-TES-1 mRNA based on reverse transcription polymerase chain reaction (RT-PCR). The detection frequency of mRNA OY-TES-1 gene in blood and tumor samples of 66 patients with CRC, as well as the blood of healthy volunteers, was evaluated.Results. In the peripheral blood of healthy volunteers, no OY-TES-1 mRNA was detected. In the blood of CRC patients, OY-TES-1 mRNA was detected in 13.6 % of cases. In tumors, it was found in 60,6 % of cases. OY-TES-1 mRNA in the blood and in tumor of patients with CRC was detected statistically significantly more often at stages III and IV than at stages I and II (11,0 and 4,5 times, respectively), and also many times more often in tumors with a low degree of differentiation than with highly differentiated tumors. In patients with CRC, the OY-TES-1 mRNA in tumors with metastases in organs and lymph nodes was detected many times more often than in tumors without any metastases (by 16,4 and 17,4 times respectively).Conclusion. The data obtained indicate the absence of mRNA OY-TES-1gene in the blood of healthy individuals, the appearance of mRNA OY-TES-1 gene in the blood of CRC patients, and the possibility of using the detection of mRNA OY-TES-1 gene in the blood as an additional informative monitoring marker for colorectal cancer.

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A Search for Cancer-Testis Genes Expression in Blood and Biopsy of Patients With Colorectal Cancer

Cited by 4 publications

References 9 publications

Type I and Ii Collagens in Breast Tumours

Type I and Ii Collagens in Breast Tumours

Immunogenic Cancer-Testis Antigens and Their Genes in Malignant Tumors

mRNA of the <i>OY-TES-1</i> gene in peripheral blood and tumors in colorectal cancer

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