Immunogenic Cancer-Testis Antigens and Their Genes in Malignant Tumors

Abstract

The analysis of CTG and CTA expression in malignant tumors described in this review has been showed that different types of tumors are significantly different from each other according to the frequency of CTA mRNA expression. Melanoma, ovarian cancer and lung cancer have a very high frequency of CTA expression. Lymphoma, kidney cancer, pancreatic cancer have a low frequency of CTA expression. Breast cancer, bladder cancer, prostate cancer demonstrate an intermediate level of CTA expression. High degree malignant tumors in late clinical stage with metastases showed a greater incidence of CTA -gene expression. CTA-genes are expressed together in tumor. If the tumor is positive for one CTA-gene then the expression of several genes is possible. Immunogenic CTA-s are a well object for anti-tumor vaccines creating.

Type I and Ii Collagens in Breast Tumours

“…In patients with colorectal cancer, the characteristic of the expression of C/T genes is incomplete, especially, for the Russian population [8]. The first study on CTA in 54 patients with colorectal cancer performed in 1996 (expression of mRNA MAGEA-1; -2; -3) revealed the hyperexpression of MAGEA-1 in 30%, MAGEA-2in 28% and MAGEA-3 in 20% of cases.…”