A Search for a Chemical Tag on the Product of the H-2 Locus1

Popp, Rüdiger; Francis, Mary W.; Popp, Diana M.

doi:10.1159/000392405

Cited by 2 publications

(2 citation statements)

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“…The nature of ultraweak photon emission (UPE) in biological systems has been reviewed by several authors previously [13, [82][83][84][85][86]. The advent of new photon-counting technologies in the early 1960s provided the tools to demonstrate the existence of low-level luminescence in all living organisms, to be distinguished from the strong bioluminescence of, for example, various firefly and squid species.…”

Section: Potential For Using Ultraweak Photon Emissions In Diagnosismentioning

confidence: 99%

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease

Kurian

Obisesan

Craddock

2017

Journal of Photochemistry and Photobiology B: Biology

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Oxidative stress is a pathological hallmark of neurodegenerative tauopathic disorders such as Alzheimer’s disease and Parkinson’s disease-related dementia, which are characterized by altered forms of the microtubule-associated protein (MAP) tau. MAP tau is a key protein in stabilizing the microtubule architecture that regulates neuron morphology and synaptic strength. When MAP tau is degraded in tauopathic disorders, neuron dysfunction results. The precise role of reactive oxygen species (ROS) in the tauopathic disease process, however, is poorly understood. Classically, mitochondrial dysfunction has been viewed as the major source of oxidative stress and has been shown to precede tau and amyloid pathology in various dementias, but the exact mechanisms are not clear. It is known that the production of ROS by mitochondria can result in ultraweak photon emission (UPE) within cells. While of low intensity, surrounding proteins within the cytosol can still absorb these energetic photons via aromatic amino acids (e.g., tryptophan and tyrosine). One likely absorber of these photons is the microtubule cytoskeleton, as it forms a vast network spanning neurons, is highly colocalized with mitochondria, and shows a high density of aromatic amino acids. Functional microtubule networks may traffic this ROS-generated endogenous photon energy for cellular signaling, or they may serve as dissipaters/conduits of such energy to protect the cell from potentially harmful effects. Experimentally, after in vitro exposure to exogenous photons, microtubules have been shown to reorient and reorganize in a dose-dependent manner with the greatest effect being observed around 280 nm, in the tryptophan and tyrosine absorption range. In this paper, recent modeling efforts based on ambient temperature experiment are presented, showing that tubulin polymers can feasibly absorb and channel these photoexcitations via resonance energy transfer, on the order of dendritic length scales and neuronal fine structure. Since microtubule networks are compromised in tauopathic diseases such as Alzheimer’s and Parkinson’s dementias, patients with these illnesses would be unable to support effective channeling of these photons for signaling or dissipation. Consequent emission surplus due to increased UPE production or decreased ability to absorb and transfer may lead to increased cellular oxidative damage, thus hastening the neurodegenerative process.

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Section: Potential For Using Ultraweak Photon Emissions In Diagnosismentioning

confidence: 99%

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease

Kurian

Obisesan

Craddock

2017

Journal of Photochemistry and Photobiology B: Biology

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“…The Typically, the lifetime of a battery is defined as the time it takes for the cell capacity to fall from 100% of its capacity measured at the Beginning of Life (BoL), to 80%. 29 At this point, the cell is assumed to have reached End of Life (EoL). Obviously, under normal operating conditions, it can take several months or years for a cell to degrade from BoL to EoL.…”

Section: Methodsmentioning

confidence: 99%

A New Time Constant Approach to Online Capacity Monitoring and Lifetime Prediction of Lithium Ion Batteries for Electric Vehicles (EV)

Attidekou

Wang

Armstrong

et al. 2017

J. Electrochem. Soc.

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This paper presents a new technique to determine the online capacity of a lithium ion battery for Electric Vehicle (EV) applications. A mixed calendar and cycling profile is defined and applied to a high power-density 16Ah pouch type battery. Whilst the capacity loss due to cycling is irreversible, the apparent capacity loss due relaxation/self-discharge is found to be pseudo-reversible. The characteristic voltage drop during relaxation is studied in detail, and shown to exhibit behavior which can be modelled using a dynamic time constant approach. Applying this technique, an excellent fit is obtained between the actual and model predicted relaxation curves. The results are of significant practical importance, particularly in the field of lifetime prediction of Li-Ion batteries.

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A Search for a Chemical Tag on the Product of the H-2 Locus1

Cited by 2 publications

References 0 publications

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease

A New Time Constant Approach to Online Capacity Monitoring and Lifetime Prediction of Lithium Ion Batteries for Electric Vehicles (EV)

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