A Screening Study of Hepatoprotective Activity of Liquid Extract from Common Tansy <i>Tanacetum vulgare</i> L. Herb in the setting of Subchronic Hepatitis in Rats

Kalko, K. O.; Mishchenko, O. Ya.; Derymedvid, L. V.; Zolotaikina, M. Yu.; Mashtaler, V. V.; Kutsenko, S. A.

doi:10.5958/0974-360x.2018.00803.x

Cited by 5 publications

(1 citation statement)

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“…Quinic acid, caffeic acid, and their esterified derivatives have been reported as characteristic non-volatile compounds in T. vulgare [ 38 ]. Gallic acid has been mentioned as one of the biologically active constituents of the liquid extract (ethanol 70%) of the common tansy herb recommended as a hepatoprotective agent [ 51 ]. All flavonoids (catechin, quercetin, kaempferol, rutin, and apingenin) identified in our research have been previously reported in T. vulgare as value components with a significant contribution to pharmaceutical activities [ 6 , 47 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profiling and Antioxidant Activity of Tanacetum vulgare L. Wild-Growing in Latvia

Šukele

Lauberte

Kovaļčuka

et al. 2023

Plants

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The Tanacetum vulgare L. (Tansy) has several ethnobotanical uses, mostly related to the essential oil and sesquiterpene lactones, whereas information regarding other compounds is scarce. This research is designed to characterize the phenolic compounds (flavonoids, phenolic acids, and tannins) to analyze the thujone (which is toxic in high concentrations) content and to detect the antioxidant activity (DPPH assay) of extracts. The main highlights of our work provide a chemical profile of phenolic compounds of T. vulgare harvested from different regions of Latvia, as well as simultaneously support the ethnomedicinal uses for wild T. vulgare through the integration of phenolic compounds as one of the value constituents of leaves and flowers. The extraction yield was 18 to 20% for leaves and 8 to 16% for flowers. The total phenol content in the extracts of T. vulgare as well as their antioxidant activity was different between collection regions and the aerial parts ranging from 134 to 218 mg GAE/g and 32 to 182 mg L−1, respectively. A remarkable variation in the thujone (α + β) content (0.4% up to 6%) was detected in the extracts. T. vulgare leaf extracts were rich in tannins (up to 19%). According to the parameters detected, the extracts of T. vulgare could be considered promising for the development of new herbal products.

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Section: Discussionmentioning

confidence: 99%

Chemical Profiling and Antioxidant Activity of Tanacetum vulgare L. Wild-Growing in Latvia

Šukele

Lauberte

Kovaļčuka

et al. 2023

Plants

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An Identification and a Quantitative Assessment of Phenolic Compounds in a Butanol Fraction of Extract from Cosmary Flowers (Tanacetum vulgare)

Krol

Zinnatshina²,

Baleev³

et al. 2022

Russ J Bioorg Chem

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Identification and Content of Phenolic Compounds in a Butanol Fraction of Extract From the Flowers of Tanacetum Vulgare

Krol¹,

Zinnatshina²,

Baleev³

et al. 2021

JCPRM

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Tanacetum vulgare L. (syn.: Chrysanthemum vulgare (L). Bernh) is a perennial medicinal plant with a Euro-Asian type of habitat. Tansy extracts have a wide biological and pharmacological activity. At the All-Russian Institute of Medicinal and Aromatic Plants, on the basis of the butanol fraction of the T. vulgare flowers extract was developed a drug with high choleretic and anti-inflammatory activity. In this regard, the aim of this work was to study the qualitative composition and quantitative content of phenolic compounds of the butanol fraction, which are supposed to determine its biological activity. For this was obtained a phenolic compounds fraction, isolated from the extract of inflorescences of T. vulgare plants grown on the VILAR experimental plot. High-performance liquid chromatography with diode-array detection in combination with high-resolution mass spectrometry (UPLC-PDA-HRMS) was used for the analysis. Our studies have shown that the butanol fraction of T. vulgare contains 7 phenolic compounds, among which myricetin-3-glucoside was detected for the first time. The content of phenolic compounds reaches 90%, while the main compounds are neochlorogenic, 3,5- and 4,5-dicofeylquinic acids, the proportion of which is 69%. Thus, the obtained data indicate that the pharmacological activity of the drug based on the butanol fraction of the extract from tansy flowers is due to the high content of caffeoylquinic acids.

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A Screening Study of Hepatoprotective Activity of Liquid Extract from Common Tansy Tanacetum vulgare L. Herb in the setting of Subchronic Hepatitis in Rats

Cited by 5 publications

References 0 publications

Chemical Profiling and Antioxidant Activity of Tanacetum vulgare L. Wild-Growing in Latvia

Chemical Profiling and Antioxidant Activity of Tanacetum vulgare L. Wild-Growing in Latvia

An Identification and a Quantitative Assessment of Phenolic Compounds in a Butanol Fraction of Extract from Cosmary Flowers (Tanacetum vulgare)

Identification and Content of Phenolic Compounds in a Butanol Fraction of Extract From the Flowers of Tanacetum Vulgare

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