A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

Mandeville, Ross; Sanchez, Benjamin; Johnston, Benjamin R.; Bazarek, Stanley; Thum, Jasmine A.; Birmingham, Austin; See, Reiner Henson; Leochico, Carl Froilan D.; Kumar, Viksit; Dowlatshahi, Arriyan S.; Brown, Justin M.; Stashuk, Daniel W.; Rutkove, Seward B.

doi:10.1088/1741-2552/acdbeb

Cited by 3 publications

(2 citation statements)

References 248 publications

(288 reference statements)

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“…The present scoping review serves as a complement to part 1, which specifically concentrates on non-neurophysiology [11]. Some modalities straddle neurophysiology and imaging but have only been covered by one of the reviews (such as EIT and US stimulation being covered within part 1).…”

Section: Discussionmentioning

confidence: 99%

“…This scoping review represents part 2 of a twopart review on current and emerging techniques in the evaluation of nerve health. In part 1, we performed a scoping review of the same subject but focused on neurophysiological techniques [11] (in submission). In part 2, the objective is firstly to cast a wide net to systematically identify and collate noninvasive imaging techniques that can, or have a reasonable potential to, evaluate peripheral nerve health, including approaches and techniques that may have not previously been applied to peripheral nerve.…”

Section: Introductionmentioning

confidence: 99%

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A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

et al. 2023

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Peripheral neuroregenerative research and therapeutic options are expanding exponentially. With this expansion comes an increasing need to reliably evaluate and quantify nerve health. Valid and responsive measures of the nerve status are essential for both clinical and research purposes for diagnosis, longitudinal follow-up, and monitoring the impact of any intervention. Furthermore, novel biomarkers can elucidate regenerative mechanisms and open new avenues for research. Without such measures, clinical decision-making is impaired, and research becomes more costly, time-consuming, and sometimes infeasible. Part 1 of this two-part scoping review focused on neurophysiology. In Part 2, we identify and critically examine many current and emerging non-invasive imaging techniques that have the potential to evaluate peripheral nerve health, particularly from the perspective of regenerative therapies and research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

et al. 2023

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Electrical impedance myography in healthy volunteers

Offit,

Mohammad Khanli,

et al. 2023

Muscle and Nerve

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Introduction/AimsElectrical impedance myography (EIM) is a noninvasive technique being used in clinical studies to characterize muscle by phase, reactance, and resistance after application of a low‐intensity current. The aim of this study was to obtain 50‐kHz EIM data from healthy volunteers (HVs) for use in future clinical and research studies, perform reliability tests on EIM outcome measures, and compare findings with muscle ultrasound variables.MethodsFour arm and four leg muscles of HVs were evaluated using an EIM device with two sensors, P/N 20‐0045 and P/N 014‐009. Muscles were evaluated individually and eight‐muscle average (8MU), four‐muscle upper extremity average, and four‐muscle lower extremity average. An intraclass correlation coefficient (ICC) was applied to assess interrater, intrarater, and intersensor reliability using a subset of HVs. Ultrasound studies on muscle thickness and elastography were also performed on a subset of HVs.ResultsFor the P/N 20‐0045 sensor, the 8MU EIM mean and standard deviation (n = 41) was 14.54 ± 3.31 for phase, 7.04 ± 1.22 for reactance, and 28.91 ± 7.63 for resistance. Reliability for 8MU phase (n = 22) was good to excellent for both interrater (n = 22, ICC = 0.920, 95% CI 0.820 to 0.966) and intrarater (n = 22, ICC = 0.950, 95% CI 0.778 to 0.983). The P/N 014‐009 sensor had similar reliability findings. Correlation analyses showed no association between EIM and muscle thickness.DiscussionEIM is a reproducible measure of muscle physiology. Obtaining EIM values from HVs allows us to gain a better understanding how EIM may be altered in diseased muscle.

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The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Dahlin

2023

IJMS

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Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and other related cells is crucial. Knowledge about key players associated with nerve regeneration intended for axonal outgrowth, migration of Schwann cells with respect to suitable substrates, invasion of macrophages, appropriate conditioning of extracellular matrix, activation of fibroblasts, formation of endothelial cells and blood vessels, and activation of other players in healthy and diabetic conditions is relevant. Appropriate physical and chemical attractions and repulsions are needed for an optimal and directed regeneration and are investigated in various nerve injury and repair/reconstruction models using healthy and diabetic rat models with relevant blood glucose levels. Understanding dynamic processes constantly occurring in neuropathies, like diabetic neuropathy, with concomitant degeneration and regeneration, requires advanced technology and bioinformatics for an integrated view of the behavior of different cell types based on genomics, transcriptomics, proteomics, and imaging at different visualization levels. Single-cell-transcriptional profile analysis of different cells may reveal any heterogeneity among key players in peripheral nerves in health and disease.

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A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

Cited by 3 publications

References 248 publications

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging

Electrical impedance myography in healthy volunteers

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

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