Nerve injuries due to trauma or tumor resection often result in long gaps that are challenging to repair. The best clinical option demands the use of autologous grafts that are associated with serious side effects. Bioengineered nerves are considered a good alternative, particularly if supplemented with growth factors, but current options do not match the regenerative capacity of autografts. This study revealed the synergistic effect of neurotrophins and pleiotrophins designed to achieve a broad cellular regenerative effect, and that GDNF-PTN are able to mediated axonal growth and partial functional recovery in a 4 cm nerve gap injury, albeit delays in remyelination. This report underscores the need for defining an optimal growth factor support for biosynthetic nerve implants.
Understanding the impact of deep convection on the thermodynamic structure of the tropical upper troposphere and lower stratosphere (UTLS) is vital because convection and temperatures play an important role in regulating stratospheric water vapor through direct convective injection and in enhancing the presence of thin cirrus clouds, both of which play a significant role in the climate. This study quantifies the UTLS vertical temperature structure changes near deep convection over the Pacific Warm Pool and the Tropical Atlantic Continental and Oceanic region. The deep convection observed from the Tropical Rainfall Measuring Mission satellite are collocated with high vertical resolution temperature profiles from the COSMIC GPS Radio Occultation satellites along with ERA‐Interim reanalysis from 2007 to 2011. COSMIC and ERA‐Interim observe warm temperature anomalies (0.2 to 0.8 K) within 10–14 km, then transitioning to a layer of cool anomalies (−0.4 to −1.5 K) within 14–17 km. Above the cold‐point tropopause, warm anomalies (<1 K) are observed for oceanic convection, whereas cool anomalies are displayed for land convection within 17–20 km. The amplitude of temperature anomalies increases for deeper convection, marked by higher 20 dBZ radar echo top heights or colder infrared cloud top temperatures. COSMIC also observes enhanced UTLS diurnal temperature variations of about 0.2–0.3 K in both regions near deep convection. ERA‐Interim shows generally good agreement with COSMIC on the UTLS temperature anomalies near deep convection but displays larger differences above the tropopause, especially near land convection.
Background Scientific publications are the primary vehicle for the distribution of scientific findings, but there has been limited research on literature topic surveillance. We sought to identify and characterize the most commonly published topic domains in the hand surgery literature.
Methods We performed a 6-month hypothesis testing phase to identify the most frequently published topics in three hand surgery journals: Hand, The Journal of Hand Surgery (American), and The Journal of Hand Surgery (European). We reviewed all of the published articles in these journals from June 2010 to May 2015 to identify and characterize publications related to the three most common topic domains.
Results A total of 2,146 articles were published during the 5-year study period. The three most frequent topics domains included distal radius (DR) (11% of all articles), flexor tendon (FT) (9%), and carpal tunnel (CT) (7.5%). These subjects accounted for a total of 584 articles (27% of all publications) and 3,014 published pages during the study period. FT, CT, and DR publications were cited on average 2.3 times per year (2.5, 2.4, and 2.0, respectively).
Conclusion A small subset of topic domains makes up a significant proportion of scientific publications in hand surgery.
The eruption of the Hunga Tonga–Hunga Ha’apai (HTHH) volcano on 15 January 2022 injected large amounts of water vapor (H2O) directly into the stratosphere. While normal background levels of stratospheric H2O are not detectable in radio occultation (RO) measurements, effects of the HTHH eruption are clearly observed as anomalous refractivity profiles from COSMIC-2, suggesting the possibility of detecting the HTHH H2O signal. To separate temperature and H2O effects on refractivity, we use co-located temperature observations from the Microwave Limb Sounder (MLS) to constrain a simplified H2O retrieval. Our results show enhancements of H2O up to ~2500–3500 ppmv in the stratosphere (~29–33 km) in the days following the HTHH eruption, with propagating patterns that follow the dispersing volcanic plume. The stratospheric H2O profiles derived from RO are in reasonable agreement with limited radiosonde observations over Australia. The H2O profiles during the first few days after the eruption show descent of the plume at a rate of ~−1 km/day, likely due to strong radiative cooling (~−10 K/day) induced by high H2O concentrations; slower descent (~−200 m/day) is observed over the following week as the plume disperses. The total mass of H2O injected by HTHH is estimated as 110 ± 14 Tg from measurements in the early plumes during 16–18 January, which equates to approximately 8% of the background global mass of stratospheric H2O. These RO measurements provide novel quantification of the unprecedented H2O amounts and the plume evolution during the first week after the HTHH eruption.
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