A Scoping Review and Population Study Regarding Prevalence and Histopathology of Juvenile Vulvar Melanocytic Lesions. A Recommendation

Morrel, Beth; Avoort, Irene A.M. van der; Damman, Jeffrey; Mooyaart, Antien L.; Pasmans, Suzanne G.M.A.

doi:10.1016/j.xjidi.2022.100140

Cited by 2 publications

(5 citation statements)

References 74 publications

(213 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neither did they address the possible influence of the presence of genital LS on the histological features of the melanocytic lesion. As was shown in our population study, 2 Ki‐67 positivity, a marker for malignancy, was seen to some extent in 92% of the cases of vulvar naevi in juveniles if and only if LS was present, while none were a melanoma. Moreover, our population study showed no vulvar melanomas ever recorded in a juvenile in the Netherlands national cancer registry.…”

supporting

confidence: 80%

“…With great interest we read the review article by Sim et al 1 recently published online in Skin Health and Disease on the relation of genital lichen sclerosus (LS) to melanoma. We would like to bring to the attention of the readers of your journal our recent scoping review and population study 2 on juvenile vulvar melanocytic lesions including melanoma. There are some striking differences between the two reviews, especially regarding the conclusions and recommendations made.…”

mentioning

confidence: 99%

“… 6 Population studies on vulvar melanoma do incidentally include juveniles though they do not differentiate for LS. 2 In addition, the last case of a juvenile with a vulvar melanoma to be reported dates from 2016. 6 We question if this reflect lower incidence or better diagnostics?…”

mentioning

confidence: 99%

“…In conclusion, we maintain that the diagnose of vulvar melanoma in a background of LS in childhood or adolescence is contentious, and such a lesion is more likely an AGN or a benign lesion showing atypical features. 2 , 4 , 7 Given the estimated prevalence of VLS in childhood of at least 1:900 and the extreme rarity of vulvar melanoma in a juvenile, if it truly exists at all, the question remains if the occurrence together is simply coincidental. Rightly so, clinicians and pathologists are, in general, warry of under‐diagnosis of any melanoma.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Tread carefully when considering vulvar melanoma in a child or adolescent

Morrel

Pasmans

Mooyaart

et al. 2023

Skin Health and Disease

Self Cite

View full text Add to dashboard Cite

supporting

confidence: 80%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Tread carefully when considering vulvar melanoma in a child or adolescent

Morrel

Pasmans

Mooyaart

et al. 2023

Skin Health and Disease

Self Cite

View full text Add to dashboard Cite

“…Forty‐eight histological characteristics were scored, describing features and severity of LS. Exclusion criteria were: inconclusive histological review, quality of the tissue sample too poor or the presence of a concomitant lesion such as a nevus which may affect the microscopic interpretation of LS 9 . All cases with a histologically confirmed diagnosis were then included if the person was an adult (≥18 years old) as of 1 January 2021.…”

Section: Methodsmentioning

confidence: 99%

Long‐term consequences of juvenile vulvar lichen sclerosus: A cohort study of adults with a histologically confirmed diagnosis in childhood or adolescence

Morrel,

van der Avoort,

Ewing‐Graham

et al. 2023

Acta Obstet Gynecol Scand

Self Cite

View full text Add to dashboard Cite

IntroductionVulvar lichen sclerosus (VLS) occurs in at least one in 900 girls. There is limited knowledge as to what extent the disease persists in adulthood and what the repercussions in adulthood may be. The aim of this study is to evaluate the long‐term consequences of VLS diagnosed in childhood or adolescence.Material and methodsThe population of females histologically diagnosed with VLS in childhood or adolescence in the Netherlands between 1991 and 2015 was identified through the national pathology database. Histological specimens were retrieved and re‐evaluated. Potential participants for whom the diagnosis was reconfirmed and who are now adults, were then traced and surveyed. Descriptive statistics were calculated and compared with the literature. Main outcome measures are the demographics of the cohort, their scores on standardized quality of life (QoL) and sexuality questionnaires and answers to additional questions regarding patients’ experience with the disease. The questionnaires used were the Dermatology Life Quality Index (DLQI), the Skindex‐29, the Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale‐Revised (FSDS‐R). Secondary outcome measures include obstetric history and histological features found in the original tissue specimens.ResultsA total of 81 women participated, median age 29.0 years, median follow‐up from childhood diagnosis 19.5 years. Both QoL and sexuality were somewhat affected in 51.9% of cases. Less than half (45%) reported having regular check‐ups. Forty‐five (56%) reported symptoms within the past year; of those with symptoms, 14 (31%) were not under surveillance. Cesarean section rate (14.5%) was comparable to the general population, and there were more high‐grade obstetric anal sphincter injuries with vaginal deliveries than expected. Sixteen respondents (20%) were not aware of the childhood diagnosis prior to this study.ConclusionsSymptoms due to VLS are reported by most adults diagnosed as juveniles. QoL and sexuality are affected and correlate to recent symptoms. VLS as a juvenile does not preclude a vaginal delivery. Women diagnosed with VLS in childhood or adolescence are often lost to follow‐up.

show abstract

A Scoping Review and Population Study Regarding Prevalence and Histopathology of Juvenile Vulvar Melanocytic Lesions. A Recommendation

Cited by 2 publications

References 74 publications

Tread carefully when considering vulvar melanoma in a child or adolescent

Tread carefully when considering vulvar melanoma in a child or adolescent

Long‐term consequences of juvenile vulvar lichen sclerosus: A cohort study of adults with a histologically confirmed diagnosis in childhood or adolescence

Contact Info

Product

Resources

About