A scalable 64 channel neurostimulator based on a hybrid architecture of current steering DAC

Meza-Cuevas, Mario A.; Schroeder, Dietmar; Krautschneider, Wolfgang H.

doi:10.1109/mecbme.2014.6783218

Cited by 4 publications

(9 citation statements)

References 8 publications

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“…A temperature limit of 1°C was assumed [44]. The power density at the device was obtained by following the approach seen in Luján Villarreal D, et al, (2016) [31] of 1024 evenly distributed electrodes, each with low power consumption of 54 µW [45] of an existing stimulator device.…”

Section: Jc Jcmentioning

confidence: 99%

“…Between the anodic and cathodic phases, the system is open-circuited with a delay of 100 µs. The control of selecting the role of electrodes to function as active or ground is considered as seen in previous publications [31,45]. Active electrodes can have their own time slot for stimulation [45].…”

Section: Stimulation Parametersmentioning

confidence: 99%

“…Despite that those cannot generate single-cell activation per electrode which would produce independent pixels, there is hope to achieve such challenges. Meza et al, [45] suggested the use of daisy chain configuration to connect the required amount of chips with hybrid architecture current steering that enables low power consumption and high channel integration on a small chip area. This method can increase the number of stimulation channels and generate a large area of stimulationat the retina while preserving detail perception.…”

Section: Shown Inmentioning

confidence: 99%

See 2 more Smart Citations

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

DL¹,

Wh²

2017

IJCNE

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Section: Jc Jcmentioning

confidence: 99%

Section: Stimulation Parametersmentioning

confidence: 99%

Section: Shown Inmentioning

confidence: 99%

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A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

DL¹,

Wh²

2017

IJCNE

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“…In practice it is common to use dedicated power and data wires (which may include a separate clock wire, a demultiplexer specific enable wire and a wire for stimulation commands). The total number of input wires for a demultiplexer then varies between two and nine [9], [10], [11], [23], [24], [25], [26], [27], [28] which can fit into a helical cable and be implanted safely.…”

Section: A Leads Countmentioning

confidence: 99%

Advances in Scalable Implantable Systems for Neurostimulation Using Networked ASICs

et al. 2016

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Neurostimulation is a known method for restoring lost functions to neurologically impaired patients. This paper describes recent advances in scalable implantable stimulation systems using networked application specific integrated circuits (ASICs). It discusses how they can meet the ever-growing demand for high-density neural interfacing and long-term reliability. A detailed design example of an implantable (inductively linked) scalable stimulation system for restoring lower limb functions in paraplegics after spinal cord injury is presented. It comprises a central hub implanted at the costal margin and multiple Active Books which provide the interface for stimulating nerve roots in the cauda equina. A 16-channel stimulation system using four Active Books is demonstrated. Each Active Book has an embedded ASIC, which is responsible for initiating stimulus current to the electrodes. It also ensures device safety by monitoring temperature, humidity, and peak electrode voltage during stimulation. The implant hub was implemented using a microcontroller-based circuit. The ASIC in the Active Book was fabricated using XFAB's 0.6-µm high-voltage CMOS process. The stimulation system does not require an accurate reference clock in the implant. Measured results are provided.

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“…Depth accuracy stimulation is examined at the peak volumetric density of RGCs along the vertical section at the ganglionic layer. To provide functional vision, we investigated safe stimulation of an existing ASIC design that can provide 1024 electrodes with low power consumption [Meza-Cuevas et al, 2014]. Electrochemical reactions of neural tissue heating from the retina implant, watervoltage window, and charge density injection limits were included in our study.…”

Section: Introductionmentioning

confidence: 99%

3D Electrode Array for Single-cell selectivity in Visual Prosthesis

Villarreal

Krautschneider

2020

Preprint

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Background : Visual prostheses electrically stimulate nearby neurons to generate artificial vision in patients blinded by retinal degenerative diseases. Current prosthetic devices offer limited spatial resolution that results in unselective stimulation of retinal ganglion cells (RGCs). This can be understood as a falling short of visual prosthesis to generate a complete visual scene with detail perception. In this report, the 3D linear electrode carrier is introduced. Our analysis develops a proof of principle to identify the usefulness of the 3D array to activate selectively single RGCs using small electrode size at the highest-density cell.Methods : A simulation framework was built by locating the 3D linear electrode carrier with the highest-density cell. Stimulation of the 3D carrier is implemented at horizontal meridian in the superior retina within the region of 1 mm away from the fovea centralis. Stimulation in that space is needed for critical functions such as object recognition, reading, and driving. The simulation framework obeyed the RGC density and distribution, ganglionic layer thickness, vertical distribution and cell diameter at the fovea. To verify RGC electrical stimulation, the relevant retinal interface elements and dynamics of the voltage-gated ionic channels were integrated into a 3D computational model in COMSOL Multiphysics.Results : the distribution of stimulus from a single active electrode to ground generates a volume of stimulation equivalent to the volume contained by a single RGC at the highest-density cell. Sensitive retinal tissue is safeguarded from electrochemical reactions caused by excessive charge density, the formation of corrosion and neural tissue heating since the advanced technology of the 3D array injects low thresholds for effective stimulation.Conclusions : The 3D electrode array can provide a safe stimulus to enhance visual resolution that can be delivered by +1000 electrodes. This is required in humans for activities where visual detail is of primary importance and thus relevant for high-resolution vision. The 3D electrode array reveals small proximities of electrodes to cells for activation. This is of an advantage for cells located near and very-deep in the ganglion layer because low thresholds are injected to the electrodes producing a well-defined localization of stimulus, an independent activation that targets single RGCs and a safe stimulus.

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A scalable 64 channel neurostimulator based on a hybrid architecture of current steering DAC

Cited by 4 publications

References 8 publications

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

Advances in Scalable Implantable Systems for Neurostimulation Using Networked ASICs

3D Electrode Array for Single-cell selectivity in Visual Prosthesis

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