A sandwich-type electrochemical immunosensor using trimetallic nanozyme as signal amplification for NT-proBNP sensitive detection

Recent advances in nanomaterials‐based optical sensors for detection of various biomarkers (inorganic species, organic and biomolecules)

“…[111] implications for heart failure diagnosis, efficacy evaluations, and prognosis. [223] The researchers developed an enzyme-free colorimetric immunoprobe for determining AMI biomarkers such as creatine kinase-MB (CK-MB), NT-proBNP, and cardiac muscle troponin T (cTnT). The pH-related modification of three allochroic agents, methyl red, phenolphthalein, and bromothymol blue to three-dimensional Au nanovesicles (GNVs) was used to create this biosensor.…”

“…Therefore, assessing NT‐proBNP level has a lot of implications for heart failure diagnosis, efficacy evaluations, and prognosis. [ 223 ]…”

A sensitive dual-signal electrochemiluminescence immunosensor based on Ru(bpy)32+@HKUST-1 and Ce2Sn2O7 for detecting the heart failure biomarker NT-proBNP

“…[1][2][3][4] N-terminal pro-brain natriuretic peptide (NT-proBNP), a hormone fragment secreted by the heart containing 76 amino acid peptides, is a well-recognized prognostic biomarker of heart failure and other cardiovascular diseases. [5][6][7] The age classification threshold of the floor-level serum NT-proBNP of patients is as follows: (1) 1.8 ng mL À1 (over 75 years old), (2) 900 pg mL À1 (50-75 years old), and (3) 450 pg mL À1 (younger than 50 years old). Therefore, the rapid and sensitive detection of NT-proBNP levels is vital to promote preemptive therapy and reduce the mortality of heart failure.…”

Shape dependency of gold nanorods through TMB2+-mediated etching for the visual detection of NT-proBNP

“…[6][7][8][9][10][11][12] The latter assays include electrochemical biosensors, photoelectrochemical biosensors, surface plasma resonance biosensors, electrochemiluminescence biosensors, and micro-uidic immunoassay biosensors, among others. [13][14][15][16][17][18][19][20][21][22] Large instruments are necessary for these delicate biosensors, which are expensive, uncomfortable for users, and need trained technicians. Due to these aws, it is a challenge to meet the demand for NT-proBNP monitoring in insufficient experimental settings and less developed countries.…”