Shape dependency of gold nanorods through TMB<sup>2+</sup>-mediated etching for the visual detection of NT-proBNP

Jiang, Chenlong; Lai, Xiangde; Han, Feng; Gao, Zhijun; Yang, Heejung; Zhao, Xuan; Pang, Huajie; Qiao, Bin; Peng, Hua; Wu, Qiang

doi:10.1039/d3ra00280b

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…In optical biosensors, these nanostructures can interact with light through mechanisms like surface plasmon resonance, providing a basis for sensitive detection methods based on changes in optical properties. The incorporation of nanowires and nanorods into biosensor designs, therefore, offers a means to significantly amplify the detection capabilities of NT-ProBNP, contributing to more accurate and sensitive diagnostics for HF [ 43 ].…”

Section: Nanomaterial-based Biosensors For Nt-probnp Detectionmentioning

confidence: 99%

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Lee,

Sriram,

Wang

et al. 2024

Nanomaterials

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Cardiovascular diseases (CVDs) represent a significant challenge in global health, demanding advancements in diagnostic modalities. This review delineates the progressive and restrictive facets of nanomaterial-based biosensors in the context of detecting N-terminal pro-B-type natriuretic peptide (NT-proBNP), an indispensable biomarker for CVD prognosis. It scrutinizes the escalation in diagnostic sensitivity and specificity attributable to the incorporation of novel nanomaterials such as graphene derivatives, quantum dots, and metallic nanoparticles, and how these enhancements contribute to reducing detection thresholds and augmenting diagnostic fidelity in heart failure (HF). Despite these technological strides, the review articulates pivotal challenges impeding the clinical translation of these biosensors, including the attainment of clinical-grade sensitivity, the substantial costs associated with synthesizing and functionalizing nanomaterials, and their pragmatic deployment across varied healthcare settings. The necessity for intensified research into the synthesis and functionalization of nanomaterials, strategies to economize production, and amelioration of biosensor durability and ease of use is accentuated. Regulatory hurdles in clinical integration are also contemplated. In summation, the review accentuates the transformative potential of nanomaterial-based biosensors in HF diagnostics and emphasizes critical avenues of research requisite to surmount current impediments and harness the full spectrum of these avant-garde diagnostic instruments.

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Section: Nanomaterial-based Biosensors For Nt-probnp Detectionmentioning

confidence: 99%

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Lee,

Sriram,

Wang

et al. 2024

Nanomaterials

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Flexible Au@AgNRs/MAA/PDMS-based SERS sensor coupled with intelligent algorithms for in-situ detection of thiram on apple

Guo,

Zheng,

Yin

et al. 2024

Sensors and Actuators B: Chemical

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Shape dependency of gold nanorods through TMB²⁺-mediated etching for the visual detection of NT-proBNP

Abstract: Visual detection of NT-proBNP based on the principle of HRP-catalyzed TMB conversion into TMB2+ to mediate gold nanorods etching and an ELISA system.

Cited by 2 publications

References 27 publications

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Flexible Au@AgNRs/MAA/PDMS-based SERS sensor coupled with intelligent algorithms for in-situ detection of thiram on apple

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Shape dependency of gold nanorods through TMB2+-mediated etching for the visual detection of NT-proBNP

Abstract: Visual detection of NT-proBNP based on the principle of HRP-catalyzed TMB conversion into TMB2+ to mediate gold nanorods etching and an ELISA system.

Cited by 2 publications

References 27 publications

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics

Flexible Au@AgNRs/MAA/PDMS-based SERS sensor coupled with intelligent algorithms for in-situ detection of thiram on apple

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Shape dependency of gold nanorods through TMB²⁺-mediated etching for the visual detection of NT-proBNP