A Sample and Detection Microneedle Patch for Psoriasis MicroRNA Biomarker Analysis in Interstitial Fluid

Qiao, Yuchun; Du, Jinya; Ge, Rujiao; Lu, Huiting; Wu, Chaoxiong; Li, Jinze; Yang, Shuangshuang; Zada, Shah; Dong, Haifeng; Zhang, Xueji

doi:10.1021/acs.analchem.1c04401

Cited by 31 publications

(43 citation statements)

References 50 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study concluded that these systems could effectively detect biomarkers through a minimally invasive and automated approach. This forefront procedure may allow early diagnosis as well as imminent treatment in several diseases in the future [119]. Finally, the evaluation of the curing process is the focus in multiple systems.…”

Section: Gelatin As Theranostic Agentmentioning

confidence: 99%

Progress in Gelatin as Biomaterial for Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

Tissue engineering has become a medical alternative in this society with an ever-increasing lifespan. Advances in the areas of technology and biomaterials have facilitated the use of engineered constructs for medical issues. This review discusses on-going concerns and the latest developments in a widely employed biomaterial in the field of tissue engineering: gelatin. Emerging techniques including 3D bioprinting and gelatin functionalization have demonstrated better mimicking of native tissue by reinforcing gelatin-based systems, among others. This breakthrough facilitates, on the one hand, the manufacturing process when it comes to practicality and cost-effectiveness, which plays a key role in the transition towards clinical application. On the other hand, it can be concluded that gelatin could be considered as one of the promising biomaterials in future trends, in which the focus might be on the detection and diagnosis of diseases rather than treatment.

show abstract

Section: Gelatin As Theranostic Agentmentioning

confidence: 99%

Progress in Gelatin as Biomaterial for Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On the safety side, their work shows that the microperforations created by the MAPs were healed in under 60 min. [251] A more generic study reported by Kim et al (2022) highlights the potential use of microsampling using MAPs made from hyaluronic acid for transcriptome analysis of human skin. Their results indicated a correlation between different biomarkers at the mRNA expression level and patient age.…”

Section: Connecting the Dots: Microneedle Meets Biomarkersmentioning

confidence: 99%

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Himawan

Vora

Permana

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from the fluids surrounding the diseased tissues may give more important clinical value than measuring them at a systemic level. Despite all these facts, pushing tissue fluid-based diagnosis and monitoring forward to clinical settings faces one major problem: its accessibility. Most extracellular tissue fluid, such as interstitial fluid (ISF), is abundant but hard to collect, and the currently available technologies are invasive and expensive. This is where novel microneedle technology can help tackle this significant obstacle. The ability of microneedle technology to minimally invasively access tissue fluid-containing biomarkers will enable ISF and other tissue fluid utilization in the clinical diagnosis and monitoring of localized diseases. This review attempts to present the current pursuit of the application of microneedle systems as a diagnostic and monitoring platform, along with the recent progress of biomarker detection in diagnosing and monitoring localized external organ diseases. Then, the potential use of various microneedles in future clinical diagnostics and monitoring of localized diseases is discussed by presenting the currently studied cases.

show abstract

“…For another thing, compared with injection administration, MNs can effectively reduce patients’ pain sensation, improve patients’ compliance, and avoid the occurrence of needle sickness. At present, MNs have been applied to medical beauty [ 7 ], tumor treatment [ 8 ], diabetes treatment [ 9 – 11 ], disease screening and diagnosis [ 12 ], antibacterial [ 13 ], and other fields, which have achieved good feedback. With the improvement of industrial technology, MNs have also been successfully applied in the vaccination of influenza vaccines in clinical practice [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

show abstract

A Sample and Detection Microneedle Patch for Psoriasis MicroRNA Biomarker Analysis in Interstitial Fluid

Cited by 31 publications

References 50 publications

Progress in Gelatin as Biomaterial for Tissue Engineering

Progress in Gelatin as Biomaterial for Tissue Engineering

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Contact Info

Product

Resources

About