A rule-based screening environmental risk assessment tool derived from EUSES

Verdonck, Frederik; Boeije, Geert; Vandenberghe, V.; Comber, Mike; Wolf, Watze de; Feijtel, Tom C. J.; Holt, Martin; Koch, Volker; Lecloux, André; Siebel-Sauer, Angela; Vanrolleghem, Peter A.

doi:10.1016/j.chemosphere.2004.09.060

Cited by 16 publications

(21 citation statements)

References 5 publications

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“…In particular, compounds are ranked according to 4 indicators of environmental fate and hazard, namely: octanol-water partitioning, vapor pressure, biodegradability and ecotoxicity (expressed as predicted no effect concentration, PNEC). By ranking the substances on the basis of these criteria, one can easily identify substances that should undergo a more thorough risk assessment, in accordance with European Union System for Evaluation of Substances [26]. The anilines dataset was, in particular, used to investigate the effect of weighting schemes on wPWR rankings.…”

Section: Anilinesmentioning

confidence: 99%

Weighted power–weakness ratio for multi-criteria decision making

Todeschini

Grisoni

Nembri

2015

Chemometrics and Intelligent Laboratory Systems

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Section: Anilinesmentioning

confidence: 99%

Weighted power–weakness ratio for multi-criteria decision making

Todeschini

Grisoni

Nembri

2015

Chemometrics and Intelligent Laboratory Systems

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“…The rule-based approach as presented by Verdonck et al [5] can be regarded as a 'yes/ no' approach, i.e. should the chemical be subjected to risk assessment or not.…”

Section: Introductionmentioning

confidence: 99%

“…Obviously the method of Verdonck et al [5] may be used to set up a linear rank of the compounds investigated. However, since the method applies a look-up table approach based on ranges of log K OW and log VP values and not exact values it may well be defective in relation to ranking of the substances according to their potential environmental hazard.…”

Section: Introductionmentioning

confidence: 99%

“…In practice the assessment is carried out using designated software, i.e., the European Union System for the Evaluation of Substances (EUSES) [4]. However, the EUSES tool requires a considerable number of input data including 466 input parameters, 961 connections between parameters and 132 defaults [5]. As a consequence of this, Verdonck et al [5] developed a simple rule-based screening environmental risk assessment tool derived from EUSES that in addition to information on the release scenario and production tonnage only requires information concerning octanol-water partition coefficient, vapour pressure, biodegradability and the ecotoxicity, the latter being expressed by the PNEC value.…”

Section: Introductionmentioning

confidence: 99%

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A combined QSAR and partial order ranking approach to risk assessment

Carlsen¹

2006

SAR and QSAR in Environmental Research

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QSAR generated data appear as an attractive alternative to experimental data as foreseen in the proposed new chemicals legislation REACH. A preliminary risk assessment for the aquatic environment can be based on few factors, i.e. the octanol-water partition coefficient (Kow), the vapour pressure (VP) and the potential biodegradability of the compound in combination with the predicted no-effect concentration (PNEC) and the actual tonnage in which the substance is produced. Application of partial order ranking, allowing simultaneous inclusion of several parameters leads to a mutual prioritisation of the investigated substances, the prioritisation possibly being further analysed through the concept of linear extensions and average ranks. The ranking uses endpoint values (log Kow and log VP) derived from strictly linear 'noise-deficient' QSAR models as input parameters. Biodegradation estimates were adopted from the BioWin module of the EPI Suite. The population growth impairment of Tetrahymena pyriformis was used as a surrogate for fish lethality.

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“…The core elements of the approach are shown in Figure 1 and full details of this activity are reported elsewhere ECETOC, 2004;Verdonck et al, 2005). In addition to evaluating the scientific integrity of the various approaches, ECETOC also set out to establish a process for soliciting the views of stakeholders with the aim of ensuring that any new approach would not only be useful for manufacturers and users of chemicals but also acceptable to regulatory authorities.…”

Section: Introductionmentioning

confidence: 99%

The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH

Money¹,

Jacobi

Penman³

et al. 2007

J Expo Sci Environ Epidemiol

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ECETOC has been developed an approach by which the health and environmental risks arising from the supply and use of chemicals can be quickly and reliably evaluated by chemical suppliers. The approach has been available as a web-based tool since 2004. During the development and implementation of the approach, ECETOC has consulted widely so that the approach is seen to meet the required levels of science while also meeting the differing needs of affected stakeholders. The consultation process has yielded a number of findings in terms of the considerations necessary for implementing successful riskinformed decision-making in a multi-stakeholder environment. Concurrently, as the European Commission's REACH legislative package has begun to take shape, it has also become apparent that the approach has a number of potential applications for aiding the process of risk assessment under REACH. This paper reviews these experiences within the broader context of the expectations that REACH places on chemical manufacturers and suppliers. In particular, it highlights the key role that REACH Exposure Scenarios have for evaluating, managing and communicating chemical risks.

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A rule-based screening environmental risk assessment tool derived from EUSES

Cited by 16 publications

References 5 publications

Weighted power–weakness ratio for multi-criteria decision making

Weighted power–weakness ratio for multi-criteria decision making

A combined QSAR and partial order ranking approach to risk assessment

The ECETOC approach to targeted risk assessment; lessons and experiences relevant to REACH

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