A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis

Kim, Noori; Han, Kyungsup; Su, Pei-Chen; Kim, Insup; Yoon, Yong‐Jin

doi:10.1038/s41598-021-88647-0

Cited by 9 publications

(4 citation statements)

References 52 publications

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Section: Fundamentals Of Nanowire Fabrication Processmentioning

confidence: 99%

“…This stage frequently involves a type of self-limiting oxidation (Figure 1). Suspension, electrochemical deposition, and vapor deposition are three prominent ways to construct nanowires [32]. There are other additional techniques for synthesizing nanowires that are being carefully studied, developed, and used for biosensor applications:…”

Section: Fundamentals Of Nanowire Fabrication Processmentioning

confidence: 99%

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Recent Applications and Prospects of Nanowire-Based Biosensors

Tran

et al. 2023

Processes

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High-sensitivity biomedical sensors could make it possible to detect and classify chemical and biological species in a variety of applications, from disease diagnosis to medication discovery, thus, boosting the likelihood of life-saving intervention. Synthesized nanowires have already produced advancements in a variety of sectors, including biological sensors over the last decade. When compared to macro-sized materials, the nanowires’ large surface area-to-volume ratio increased sensitivity. Their applications for biomarker, viral, and DNA detection, as well as drug discovery, are also discussed. Self-powering, reusability, sensitivity in high ionic strength solvents, and long-term stability are all examples of recent developments. Shortly, the nanowire is likely to lead to major improvements in biomedical sensors. This review provides a full overview of the nanowire sensor’s working principle and production procedure. We have discussed how to produce nanowires that can be utilized as biosensors for different bacteria and pathogens, protease, DNA and RNA, neurotransmitters, and chemical compounds. Biosensing technology has dramatically improved because of the introduction of nanowires in biosensors. This is a result of the application of new biorecognition components and transducers, improvements in the manufacture, design, and miniaturization of nanostructured devices at the micron scale, and unique approaches for the synthesis of nanowires. The versatility, robustness, and dynamic nature of sensing technologies have all improved thanks to the usage of nanowires.

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Section: Fundamentals Of Nanowire Fabrication Processmentioning

confidence: 99%

Section: Fundamentals Of Nanowire Fabrication Processmentioning

confidence: 99%

Recent Applications and Prospects of Nanowire-Based Biosensors

Tran

et al. 2023

Processes

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“…The research on novel sensing technologies like lateral flow strips and microfluidic pads are making drastic changes in early diagnosis of diseases 8 – 10 . Several biomarkers specific to certain life-threatening diseases can be detected with the help of nano system based strip sensors or microfluidic devices 11 . Among the newly emerging sensing technologies, colorimetric sensing assumes much importance because it is an easy, cost-effective and reliable technique amenable to the visual detection.…”

Section: Introductionmentioning

confidence: 99%

Development of a paper printed colorimetric sensor based on Cu-Curcumin nanoparticles for evolving point-of-care clinical diagnosis of sodium

Chandran

Janardhanan

Bayal

et al. 2022

Sci Rep

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The homeostatic control of Sodium (Na+) ion in the human body assumes paramount relevance owing to its physiological importance. Any deviation from the normal level causes serious health problems like hypernatremia, hyponatremia, stroke, kidney problems etc. Therefore, quantification of Na+ levels in body fluids has significant diagnostic and prognostic importance. However, interfering ions like Potassium ion (K+) is the major hurdle in sodium detection. In this work, we synthesized the clusters of 3–9 nm-sized highly stable and pure Copper nanoparticles surface functionalised with curcumin, through chemical reduction method. Each cluster of particles is encapsulated in a curcumin layer which is clearly visible in TEM images. The results show that these curcumin functionalized Cu NPs (CuC) are highly selective to the colorimetric detection of Na+. The ions like K+, Mg2+ and Zn2+ did not interfere with the Na+ in this sensing technique. Low-cost paper-based sensor strips are fabricated and calibrated for the sensing of sodium in the physiological range and shade cards were developed as a calorimetric guide for estimation of Na+ which makes them ideal point of care diagnostic platform. We demonstrate that the proposed CuC paper strip can be used for detecting Na+ concentration within the whole physiological range in both blood serum and urine.

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“…One of the most active applications in the LOC is observed in biomedical research with Point-of-care (POC) diagnostic devices. The POC diagnostic system can rapidly deliver diagnostic outcomes to patients providing the users with many bene ts over the traditional diagnostic methods such as straightforward and easy-to-use interface, portability, less sample and reagent consumption, etc 4 .…”

Section: Introductionmentioning

confidence: 99%

Lab On a Chip System for Size-Based Gold and Polymer Nanoparticle Separation

Yoon

Kim

Lee

et al. 2021

Preprint

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Despite the increasing demand for nanoscale biomolecule analysis for point-of-care (POC) application, nanoparticle separation remains a challenge in many applications due to huge sample loss during separation, low throughput, large scale input materials requirement, and sophisticated technologies. As the separation efficiency may affect the subsequent sample processing and analysis, a robust and reliable size-based separation technique is necessary. This study presents a lab on a chip system to enhance the separation performance by using rapid and straightforward polymer prototyping. In particular, the system consists of a microfluidic network with embedded membrane filters with different pore size cut-offs and an ultrasonic transmitter for acoustic agitation. Using the novel system, we successfully demonstrate the fractionation of 15 nm Au NP from polydisperse nanoparticle solution in the presence of ultrasonic wave (28-40 kHz) generated by the transducer incorporated with the microfluidic system during the separation. Ultrasonic irradiation helps in preventing cake formation and reversing the fouling process by acoustic agitation. The suggested system significantly increases the flow rate during the separation process and improves the recovery of target size nanoparticles. This microfluidic platform is expected to serve as a powerful tool for sample preparation and analytical methodology in POC applications.

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A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis

Cited by 9 publications

References 52 publications

Recent Applications and Prospects of Nanowire-Based Biosensors

Recent Applications and Prospects of Nanowire-Based Biosensors

Development of a paper printed colorimetric sensor based on Cu-Curcumin nanoparticles for evolving point-of-care clinical diagnosis of sodium

Lab On a Chip System for Size-Based Gold and Polymer Nanoparticle Separation

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