Development of a paper printed colorimetric sensor based on Cu-Curcumin nanoparticles for evolving point-of-care clinical diagnosis of sodium

Abstract

The homeostatic control of Sodium (Na+) ion in the human body assumes paramount relevance owing to its physiological importance. Any deviation from the normal level causes serious health problems like hypernatremia, hyponatremia, stroke, kidney problems etc. Therefore, quantification of Na+ levels in body fluids has significant diagnostic and prognostic importance. However, interfering ions like Potassium ion (K+) is the major hurdle in sodium detection. In this work, we synthesized the clusters of 3–9 nm-sized highly stable and pure Copper nanoparticles surface functionalised with curcumin, through chemical reduction method. Each cluster of particles is encapsulated in a curcumin layer which is clearly visible in TEM images. The results show that these curcumin functionalized Cu NPs (CuC) are highly selective to the colorimetric detection of Na+. The ions like K+, Mg2+ and Zn2+ did not interfere with the Na+ in this sensing technique. Low-cost paper-based sensor strips are fabricated and calibrated for the sensing of sodium in the physiological range and shade cards were developed as a calorimetric guide for estimation of Na+ which makes them ideal point of care diagnostic platform. We demonstrate that the proposed CuC paper strip can be used for detecting Na+ concentration within the whole physiological range in both blood serum and urine.

Visible light sensing of ions by a cyanoquinoxaline 1,4-dioxide-based probe and its applications

“…Taking this into account and given the possibility of non-invasive analyte detection with urine, we decided to prepare simulated urine using the known protocol. 38 Initially, the prepared urine solution was spiked with different quantities of Cu 2+ ions (2–8 μM). Gratifyingly, ACQ detected the presence of Cu 2+ in the urine samples.…”

Wearable Natural Rubber Latex Gloves with Curcumin for Torn Glove Detection in Clinical Settings

“…Curcumin-based fluorescent probes can solve the lack of organic fluorescent dyes, for example, low quantum yield, and poor photostability [ 13 , 14 ]. Furthermore, since curcumin possesses multifunctional based fluorescence probes with high sensitivity, selectivity, and stability, much research has been published on chemosensor [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] and biosensor [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ] applications of curcumin [ 12 ]. Thus, a strong body of foundational knowledge relating to the use of this compound is readily available.…”

Small‐Molecule Fluorescent Probe: Ratiometric and Selective Detection of Sodium Ions for Imaging and Solid‐State Sensing Applications

“…However, they were based on crown ether derived chelators, peptides, enzymes, proteins, and nucleic acids. Recently, curcumin functionalized Cu nano particles has been developed for paper based sodium sensor on the basis of colorimetric method [32] . Ion‐sensitive field‐effect transistors (ISFETs) based carbon nanotubes sensor has also been applied to detect the sodium ions in artificial sweat [33] .…”

“…Recently, curcumin functionalized Cu nano particles has been developed for paper based sodium sensor on the basis of colorimetric method. [32] Ion-sensitive field-effect transistors (ISFETs) based carbon nanotubes sensor has also been applied to detect the sodium ions in artificial sweat. [33] Most of the sodium sensor had significant interference with K + , the existence of which is higher in biological system and have the similar chemical properties.…”