A rostro-caudal dissociation in the dorsal and ventral striatum of the juvenile SHR suggests an anterior hypo- and a posterior hyperfunctioning mesocorticolimbic system

Papa, Michèle; Diewald, L.; Carey, M. P.; Esposito, F.; Carnevale, U.A. Gironi; Sadile, A.G.

doi:10.1016/s0166-4328(01)00421-1

Cited by 47 publications

(34 citation statements)

References 31 publications

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“…However, a non-linear dose-response relation- ship is common in behavioral tests with cannabinoid agonists (Sanudo-Pena et al 1997;Valjent and Maldonado 2000;Braida et al 2004;Quinn et al 2008). As discussed above, alterations in the cannabinoid (Adriani et al 2003) and dopamine (Papa et al 2002) systems that have been reported in adolescent SHR rats may contribute to the rewarding effects of cannabinoids specifically observed in these animals. In Wistar rats, WIN induced place aversion (0.25-2.5 mg/kg) in adults, whereas no effects were observed in adolescents.…”

Section: Discussionmentioning

confidence: 89%

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder

et al. 2009

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Section: Discussionmentioning

confidence: 89%

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder

et al. 2009

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“…A number of signaling molecules/ mechanisms involved in gene regulation are affected by methylphenidate treatment. These include, for example, the dopamine transporter (Izenwasser et al, 1999;Moll et al, 2001) and the vesicular monoamine transporter (Sandoval et al, 2002); levels of GluR2 glutamate receptors (Andersen et al, 2002) and D1 dopamine receptors (Papa et al, 2002); protein kinase A and dopamine-stimulated adenylyl cyclase activities (Crawford et al, 1998); as well as the transcription factor CREB (Andersen et al, 2002). Several of these play a role in the regulation of dopamine-mediated c-fos and zif 268 expression in the striatum, and such changes could thus underlie altered gene induction after repeated methylphenidate treatment.…”

Section: Methylphenidate-induced Gene Regulation M Yano and H Steinermentioning

confidence: 99%

Topography of Methylphenidate (Ritalin)-Induced Gene Regulation in the Striatum: Differential Effects on c-Fos, Substance P and Opioid Peptides

Yano

Steiner

2004

Neuropsychopharmacol

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Dopamine action alters gene regulation in striatal neurons. Methylphenidate increases extracellular levels of dopamine. We investigated the effects of acute methylphenidate treatment on gene expression in the striatum of adult rats. Molecular changes were mapped in 23 striatal sectors mostly defined by their predominant cortical inputs in order to determine the functional domains affected. Acute administration of 5 and 10 mg/kg (i.p.) of methylphenidate produced robust increases in the expression of the transcription factor c-fos and the neuropeptide substance P. Borderline effects were found with 2 mg/kg, but not with 0.5 mg/kg. For 5 mg/kg, c-fos mRNA levels peaked at 40 min and returned to baseline by 3 h after injection, while substance P mRNA levels peaked at 40-60 min and were back near control levels by 24 h. These molecular changes occurred in most sectors of the caudate-putamen, but were maximal in dorsal sectors that receive sensorimotor and medial agranular cortical inputs, on middle to caudal levels. In rostral and ventral striatal sectors, changes in c-fos and substance P expression were weaker or absent. No effects were seen in the nucleus accumbens, with the exception of c-fos induction in the lateral part of the shell. In contrast to c-fos and substance P, acute methylphenidate treatment had minimal effects on the opioid peptides dynorphin and enkephalin. These results demonstrate that acute methylphenidate alters the expression of c-fos and substance P preferentially in the sensorimotor striatum. These molecular changes are similar, but not identical, to those produced by other psychostimulants.

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“…The spontaneously hypertensive rat strain (SHR) is a validated model of ADHD (Sagvolden et al 1993;Mook and Neuringer 1994;Aspide et al 2000;Sadile 2000;Sagvolden 2000;Papa et al 2002;Russel 2002). In particular, there are considerable advantages in the use of adolescent, rather than adult, SHRs.…”

Section: Introductionmentioning

confidence: 99%

Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats

et al. 2004

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The attention deficit/hyperactivity disorder (ADHD) can affect human infants and adolescents. One important feature of this disorder is behavioural impulsivity. This study assessed the ability of chronic acetyl-L-carnitine (ALC, saline or 100 mg/kg SC, plus 50 mg/kg orally) to reduce impulsivity in a validated animal model for ADHD. Food-restricted rats were tested during adolescence (postnatal days, pnd, 30-45) in operant chambers with two nose-poking holes, one delivering one food pellet immediately, and the other five pellets after a delay. Delay length was increased over days (from 0 to 80 s). Individual differences in the preference-delay curve emerged, with the identification of two distinct subpopulations, i.e. one with a nearly horizontal curve and another with a very steep ("impulsive") slope. The impulsivity profile was slightly but consistently reduced by chronic ALC administration. Consistent results were also obtained with methylphenidate (MPH, saline or 3 mg/kg IP twice daily). Impulsive rats exhibited a lower metabolite/serotonin (5HIAA/5HT) ratio in the medial frontal cortex (MFC) and lower noradrenaline (NA) levels in the MFC and cingulate cortex (CC) when compared with the other subgroup. The ALC treatment increased NA levels in the CC and the 5HIAA/5HT ratio in both CC and MFC. Present data suggest that ALC, a drug devoid of psychostimulant properties, may have some beneficial effects in the treatment of ADHD children.

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A rostro-caudal dissociation in the dorsal and ventral striatum of the juvenile SHR suggests an anterior hypo- and a posterior hyperfunctioning mesocorticolimbic system

Cited by 47 publications

References 31 publications

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder

Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder

Topography of Methylphenidate (Ritalin)-Induced Gene Regulation in the Striatum: Differential Effects on c-Fos, Substance P and Opioid Peptides

Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats

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