A role of LINE-1 in telomere regulation

Mueller, Catharina; Aschacher, Thomas; Wolf, Brigitte; Bergmann, Michael

doi:10.2741/4645

Cited by 15 publications

(11 citation statements)

References 53 publications

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“…Therefore, the significantly higher expression of the full-length LINE-like transcript in longlived Greenland sharks is an unexpected result. However, increased LINE-1 expression is also associated with maintenance of the telomere (Mueller et al 2018). Since telomere shortening is widely recognized as one of the hallmarks of aging (Aunan et al 2016), the active transcription of this LINE-like RNA suggests its potential to preserve genome stability and to improve telomere maintenance.…”

Section: Discussionmentioning

confidence: 99%

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

Bartas,

Červeň,

Valková

et al. 2024

Czech Polar Rep.

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The Greenland shark (Somniosus microcephalus) is an enigmatic species known for its exceptional longevity and extraordinary adaptations to the cold environment. This animal lives in the arctic and subarctic regions of the North Atlantic Ocean. Surprisingly, even though it is a vertebrate with the longest known lifespan, its transcriptome has not been studied yet. Therefore, we isolated and analyzed RNA in the Greenland shark samples. Our findings reveal some important information about the possible genetic mechanisms that could contribute to its longevity. We identified a highly expressed long interspersed nuclear element-like transcript (LINE-like) that is supposed to be associated with extended lifespan and resilience to age-related diseases, possibly through an improved telomere maintenance mechanism. This research not only contributes to our understanding of the biology and evolution of the Greenland shark but could also have implications for human longevity research.

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Section: Discussionmentioning

confidence: 99%

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

Bartas,

Červeň,

Valková

et al. 2024

Czech Polar Rep.

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“…2, 3, 4), which was possibly responsible for stronger progressiveness of Lmb V23.1.3. The LINE element was the most active transposon in human genomes (Ramos et al 2021), participating in regulation of telomere structure, and leading to malignant cell proliferation (Mueller et al 2018) and tumor formation. Therefore, we speculated that the LINE elements in Lmb V23.1.3 could maintain telomere structure of genome, producing unlimited cell proliferation, and resulting in stronger pathogenicity.…”

Section: Size Proportion Counts Of Various Transposons Of Blackleg Ca...mentioning

confidence: 99%

Genome transposon analysis of blackleg causal pathogen

Tian,

Hao,

et al. 2024

Preprint

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Background To understand genome transposon presence of blackleg pathogen and the relationship between its pathogenicity and transposons, we performed transposon analysis of blackleg pathogen through bioinformatics. Results For three pathogen strains, their genome transposon proportion was distantly beyond 4%, the pathogen strain Lmb V23.1.3 indicated the most genome transposons, followed by Lbb B3.5 and Lbb CA1, the LTR retrotransposons proportion was obviously more than other types of transposons and the Ty3/Gypsy retrotransposon proportion was greater than Ty1/Copia retrotransposons. there were no Ty1/Copia retrotransposons in Lbb CA1. Most Ty1/Copia and Ty3/Gypsy retrotransposons presented distinct evolutionary distance among different pathogen strains. Besides, the higher LTR retrotransposon density, the lower gene density, the Solo-LTR retrotransposons were much greater than intact LTR retrotransposons. Both Solo-LTR and intact LTR retrotransposon counts were the highest in Lmb V23.1.3, followed by Lbb B3.5 and Lbb CA1 respectively. Many intact LTR retrotransposons in Lmb V23.1.3 were more ancient than those in Lbb B3.5 and Lbb CA1. However, lots of homologous LTR retrotransposons in Lmb V23.1.3 were younger than those in Lbb B3.5 and Lbb CA1. No common intact LTR retrotransposons were identified between L. maculans species and L. biglobosa species, and significantly few even between two strains of the same pathogen species. Large number of special intact LTR retrotransposons in L. biglobosa were relatively younger than those in L. maculans. In addition, the LINE elements only occurred in Lmb V23.1.3, which was possibly responsible for its stronger pathogenicity. Conclusions Some pathogen strains of L. biglobosa species also contained genome transposon of distantly beyond 4%. For both L. biglobosa and L. biglobosa species, the LTR retrotransposon proportion was obviously more than other types of transposons. There was distinct evolutionary distance of LTR retrotransposons and no common intact LTR retrotransposons between two pathogen species. The Ty3/Gypsy retrotransposon proportion was greater than Ty1/Copia retrotransposons. Large number of special intact LTR retrotransposons in L. biglobosa were relatively younger than those in L. maculans. The LINE elements only occurred in Lmb V23.1.3 of L. maculans species, which was possibly responsible for its stronger pathogenicity.

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“…Among diverse types of transposons, the size, proportion and number of LTR 3, 4). The LINE transposons were found to be greatly active in human genomes (Ramos et al 2021), participating in regulation of telomere structure and leading to malignant cell proliferation and tumor formation (Mueller et al 2018).…”

Section: Size Proportion and Number Of Various Transposons Of Blackle...mentioning

confidence: 99%

Genome transposon analysis of blackleg pathogen (Leptosphaeria spp.)

Tian,

Hao,

et al. 2024

Preprint

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Background To understand presence of genome transposons of blackleg pathogen and to explore potential relationship between transposons and pathogenicity, we performed genome transposon analysis for various blackleg pathogen strains. Results The genome transposon proportion was approximately 30%, 18% and 10% in three blackleg pathogen strains, Lmb V23.1.3, Lbb B3.5 and Lbb CA1, respectively. For the three blackleg pathogen strains, the LTR retrotransposon percentage was obviously more than other types of transposons, and the counts of Ty3/Gypsy superfamily of intact LTR retrotransposons was much greater than that of Ty1/Copia superfamily. The LINE elements were only discovered in the blackleg pathogen strain Lmb V23.1.3. A great many of homologous LTR retrotransposons in Lmb V23.1.3 were younger than those in Lbb B3.5 and Lbb CA1. However, the majority of intact LTR retrotransposons in Lmb V23.1.3 were more ancient than those in Lbb B3.5 and Lbb CA1. Most of Ty1/Copia and Ty3/Gypsy superfamilies of intact LTR retrotransposons from different blackleg pathogen strains clustered into various branches in phylogeny trees. Besides, statistical analysis of gene density and LTR retrotransposon density revealed an inverse relationship between them in three blackleg pathogen strains whose solo-LTR retrotransposons were much more than intact LTR retrotransposons. The blackleg pathogen strain Lmb V23.1.3 contained the highest counts of both solo-LTR and intact LTR retrotransposons, followed by Lbb B3.5 and Lbb CA1, respectively. Pan-genome transposon analysis suggested that there no common families of intact LTR retrotransposons between L. maculans and L. biglobosa species, and fewer common families of intact LTR retrotransposons were identified even between various blackleg pathogen strains of same Leptosphaeria species. Large number of common families of intact LTR retrotransposons in L.biglobosa species were relatively younger than those in L.maculans species. Conclusions The highly virulent L.maculans species has much greater proportion of transposons compared to the weakly virulent L.biglobosa species. There was a considerable evolutionary distance among intact LTR retrotransposons from L.maculans and L.biglobosa species, and there were no common families of intact LTR retrotransposons between the two species. The genome of blackleg pathogen displayed higher proportion of LTR retrotransposons, with a relatively greater abundance of Ty3/Gypsy superfamilies of intact LTR retrotransposons compared to Ty1/Copia superfamilies. The long terminal repeats at both ends of LTR retrotransposons possibly accumulate more mutations over time, and the intermediate domains are relatively conserved. Besides, there were significantly higher number of solo-LTR retrotransposons compared to intact LTR retrotransposons, and an inverse relationship between gene density and LTR retrotransposon density was observed in the blackleg pathogen. LINE elements in Lmb V23.1.3 possibly resulted in its stronger pathogenicity in B.napus crops.

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A role of LINE-1 in telomere regulation

Cited by 15 publications

References 53 publications

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome

Genome transposon analysis of blackleg causal pathogen

Genome transposon analysis of blackleg pathogen (Leptosphaeria spp.)

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