A role for TNF in bone resorption of deciduous molars in human beings

Aim: This study aims to find out the proinflammatory chemokines macrophage inflammatory protein (MIP)-1α and MIP-1β levels in gingival crevicular fluid (GCF) of primary, mixed, and permanent dentitions. Materials and Methods: GCF of 160 individuals (4–15 years of age) was collected by the extracrevicular method. They were categorized into four groups (40 per each group). Group I: subjects with primary dentition (4–5 years of age), Group II: 40 subjects in early transition period (6–8 years), Group III: 40 individuals in the late transition period (9–11 years), and Group IV: 40 individuals with permanent dentition (12–15 years). MIP-lα and MIP-1β levels were determined in the samples of GCF by ELISA method. Data were analyzed by software SPSS Version 20 (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY: USA). Results: MIP-1α and MIP-1β were detected in all samples. The highest mean MIP-1α and MIP-1β concentrations in GCF were detected in the early transition period, while the lowest concentrations were seen in primary dentition group. The chemokine levels were higher in girls than in boys in Group III. There was a substantial rise of MIP-1α and MIP-1β levels during eruption. Conclusions: Since levels of MIP-1α and MIP-1β in GCF are positively associated with tooth eruption, they may perhaps be deemed as novel biomarkers in the eruption process.

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“…Moreover, if tooth was replaced with amalgam, keeping DF intact, the artificial tooth erupted. [8910]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of levels of proinflammatory chemokines MIP-1α and MIP-1β in gingival crevicular fluid of primary, mixed and permanent dentition

Swathi¹,

Charitha

Deepthi

et al. 2019

J Int Soc Prevent Communit Dent

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Expression of tumour necrosis factor-alpha in the rat dental follicle

Wise

Yao

2003

Archives of Oral Biology

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Treatment of ankylosed deciduous molars with or without permanent successors in children and adolescents: a systematic review

Savoldi¹,

Dalessandri²,

Gardoni³

et al. 2022

Minerva Dent Oral Sc

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HTML PDF Materiale_supplementareINTRODUCTION: The aim of this systematic review was to provide guidelines for decision-making during orthodontic treatment planning of infra-occluded deciduous molars with or without their successors in children and adolescents. EVIDENCE ACQUISITION: Computerized search was conducted on Medline via PubMed, and Cochrane Library. Articles published until 2020 in English language were analyzed following the Preferred Reporting Items for Systematic Reviews (PRISMA) Checklist. Observational and interventional longitudinal studies reporting the treatment of ankylosed deciduous molars with or without successor tooth in 3 to 15-year-old patients were included. EVIDENCE SYNTHESIS: In case of ankylosis with presence of successor, exfoliation took place in 77% of teeth, while extraction involved 23%. Infra-occlusion happened in 53% of teeth (worsening in 52%), alveolar bone loss in 37%, mesial tipping of first permanent molar in 5%, and over-eruption of antagonist in no cases (after exfoliation and eruption of successor). In case of ankylosis without successor, exfoliation took place in 1% of teeth, progression of infra-occlusion in 42%, progression of root resorption in 58%, development of mesial tipping of first permanent molars in 25%, while no case of antagonist over-eruption was reported. CONCLUSIONS: When the permanent tooth is present and the ankylosed tooth is slightly or moderately infra-occluded, observation is appropriate. In case of severe infra-occlusion or absence of successor, tooth extraction may be considered together with orthodontic space closure, transplantation, or prosthetic replacement. Alternatively, nonextraction and a prosthetic build-up may be considered.

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A role for TNF in bone resorption of deciduous molars in human beings

Cited by 3 publications

References 31 publications

Evaluation of levels of proinflammatory chemokines MIP-1α and MIP-1β in gingival crevicular fluid of primary, mixed and permanent dentition

Evaluation of levels of proinflammatory chemokines MIP-1α and MIP-1β in gingival crevicular fluid of primary, mixed and permanent dentition

Expression of tumour necrosis factor-alpha in the rat dental follicle

Treatment of ankylosed deciduous molars with or without permanent successors in children and adolescents: a systematic review

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