A role for melatonin in maintaining the pro- and anti-inflammatory balance by influencing leukocyte migration and apoptosis in carp

Kepka, M.; Szwejser, Ewa; Pijanowski, L.; Kemenade, B.M.L. Verburg-van; Chadzińska, Magdalena

doi:10.1016/j.dci.2015.07.011

Cited by 27 publications

(21 citation statements)

References 90 publications

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“…In another animal study, melatonin in combination with pravastatin noticeable enhanced expression of both caspase‐3 and caspase‐7 in rat mammary carcinoma cells in comparison with pravastatin alone . These results are in contrast with those of Kepka et al, where melatonin was shown to significantly reduce the early and late apoptosis of peritoneal leucocytes, by specifically inhibiting the extrinsic apoptosis pathway.…”

Section: Discussionmentioning

confidence: 99%

Melatonin and IL‐25 modulate apoptosis and angiogenesis mediators in metastatic (CF‐41) and non‐metastatic (CMT‐U229) canine mammary tumour cells

Gelaleti

Borin

Maschio‐Signorini

et al. 2017

Vet Comparative Oncology

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Section: Discussionmentioning

confidence: 99%

Melatonin and IL‐25 modulate apoptosis and angiogenesis mediators in metastatic (CF‐41) and non‐metastatic (CMT‐U229) canine mammary tumour cells

Gelaleti

Borin

Maschio‐Signorini

et al. 2017

Vet Comparative Oncology

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“…The presence of MT1 receptors on carp leucocytes as well as significant effects of melatonin on leucocyte migration and apoptosis during zymosan‐induced peritonitis were also observed in C. carpio (Kepka et al . ). Those authors described a potent anti‐inflammatory function for this hormone, whereas the observed melatonin‐induced inhibition of leucocyte apoptosis indicates towards a dual function.…”

Section: Tryptophan and Immune Responsementioning

confidence: 97%

“…The melatonin receptors have been cloned in fish, and partial or full-length sequences for the three high-affinity melatonin receptor subtypes, MT1, MT2 and Mel1c, have been obtained for several fish species (Esteban et al 2013). The presence of MT1 receptors on carp leucocytes as well as significant effects of melatonin on leucocyte migration and apoptosis during zymosaninduced peritonitis were also observed in C. carpio (Kepka et al 2015). Those authors described a potent anti-inflammatory function for this hormone, whereas the observed melatonin-induced inhibition of leucocyte apoptosis indicates towards a dual function.…”

Section: Tryptophan and Immune Responsementioning

confidence: 98%

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Hoseini

Pérez‐Jiménez

Costas

et al. 2017

Reviews in Aquaculture

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Tryptophan is an essential amino acid with a huge functional versatility, in addition to its participation in protein synthesis. Because of the complexity of its metabolism, and the functional relevance of several of its metabolites, it directly or indirectly participates in a wide array of physiological pathways. This amino acid is a precursor for the synthesis of the neurotransmitter/neuromodulator serotonin (5HT), the hormone melatonin and kynurenine and related compounds such as kynurenic acid, quinolinic acid or niacin. Because of this, it has a key role in the regulation of processes ranging from the neuroendocrine to the immune system in vertebrates. In aquaculture, extensive research has been performed to optimize the levels of tryptophan in the commercial diets for many fish species. Providing adequate levels of this amino acid is critically important for fish growth but also for fish welfare, as tryptophan has been shown to modulate fish behaviour, stress responses, and antioxidant and immune systems. Currently, available data suggest a wide variation in tryptophan requirements of different species ranging 0.3–1.3% of dietary protein level, but recent evidence also shows that fish tryptophan requirements can greatly vary depending on the rearing conditions of the fish. We also review here the participation of tryptophan and related metabolites in different physiological functions that are crucial for fish welfare. The review covers the involvement of tryptophan in 5HT‐ and melatonin‐mediated functions, along with its participation in the regulation of the immune system and its role as an antioxidant and antitoxic agent in fish.

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“…It has been well documented that the complex interaction of oxidative stress and inflammation results in many diseases. Melatonin could not only reduce the oxidative levels as stated, but also effectively fight against inflammation via different mechanisms such as essential signaling pathways [70,149], the modulation of related genes [150] and the activation membrane receptors [151], as discussed in detail below.…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

“…It was found that melatonin played a role in maintaining the pro- and anti- inflammatory balance during infection by influencing leukocyte migration and apoptosis in carp possibly mediated by melatonin MT1 receptors in/on leukocytes [151]. …”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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A role for melatonin in maintaining the pro- and anti-inflammatory balance by influencing leukocyte migration and apoptosis in carp

Cited by 27 publications

References 90 publications

Melatonin and IL‐25 modulate apoptosis and angiogenesis mediators in metastatic (CF‐41) and non‐metastatic (CMT‐U229) canine mammary tumour cells

Melatonin and IL‐25 modulate apoptosis and angiogenesis mediators in metastatic (CF‐41) and non‐metastatic (CMT‐U229) canine mammary tumour cells

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Dietary Sources and Bioactivities of Melatonin

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