A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour

REVIEW ARTICLE: Th1/Th2/Th17 and Regulatory T‐Cell Paradigm in Pregnancy

“…Indeed, the IKK inhibitor and MAPK inhibitor significantly inhibited IL-17 with TNFa-induced IL-8 secretion in amniotic mesenchymal cells. 34 These findings show that Th17 cells promote inflammation at the fetomaternal interface in preterm delivery. Th1 ⁄ Th2 ⁄ Th17 and Treg paradigms in preeclampsia…”

“…Our groups recently found that Th17 cell number is increased in the chorioamniotic membrane of preterm delivery cases with chorioamnionitis (CAM). 34 Amniotic fluid IL-17 levels in severe CAM (stage III) preterm delivery cases were significantly higher than those in CAM-negative preterm delivery cases. Amniotic fluid IL-17 levels were positively correlated with IL-8 levels.…”

“…Further studies are needed to determine circulating Th17 cell levels during pregnancy. 34 Previous studies demonstrate that elevation of IL-17 is observed in acute renal rejection, 35 suggesting that increased Th17 cells in pregnancy decidua might be disadvantageous for the maintenance of pregnancy. 33 Unexpectedly, the frequency of Th17 cells in the decidua is significantly higher compared to that in peripheral blood.…”

THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4⁺Т LYMPHOCYTES DURING PREGNANCY

“…Increased Th17-cell count in decidua is noted in women with spontaneous abortions [67]. IL-17 participation in inflammation initiation during premature delivery was noted [43]. Th17 cell participation in infertility formation was observed, as well [56].…”

Prediction of spontaneous preterm delivery in women with preterm labor: Analysis of interleukin-17, migration inhibitory factor, monocyte chemotactic protein-1 in maternal serum and cervicovaginal fluid

“…Monosit kemotaktik ve aktive edici faktör olarak da bilinen MCP-1'in, hedef hücre spesifisitesi nedeniyle mononük-leer hücre infiltrasyonu ile karakterize ateroskleroz, romatoid artrit, alerjik hastalıklar gibi pek çok hastalıkta rol oynadığı gösterilmiştir [13]. Yakın zamanda yapılan çalışmalarda IL-17, MIF ve MCP-1'in preterm doğumda rol oynayabileceği ileri sü-rülmektedir [14,15]. Bu çalışmada, preterm eylemdeki hastaların serum ve servikovaginal yıkama sıvılarında IL-17, MIF ve MCP-1 düzeylerinin tek başlarına veya transvaginal ultrasonografi kullanılarak yapılan servikal uzunluk ölçümü ya da anamneze dayalı risk faktör-leri ile birlikte preterm doğumu öngörmedeki gücünün saptanması amaçlanmıştır.…”