A Role for Hepatitis C Virus Infection in Type II Cryoglobulinemia

Agnello, Vincent; Chung, Raymond T.; Kaplan, Lee M.

doi:10.1056/nejm199211193272104

Cited by 1,205 publications

(620 citation statements)

References 28 publications

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“…Besides, an important association has been demonstrated between HCV and lymphoproliferative disorders. Many studies have shown an increased prevalence of HCV infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL), and the prevalence is between 9% and 32% [2][3][4][5][6][7][8][9][10]. In these studies, HCV has been tested serologically, but today the prevalence of HCV in lymphoproliferative disorders is not known.…”

Section: Introductionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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The aim of this study is to detect the possible role of hepatitis C Virus (HCV) in lymphomagenesis. HCV‐RNA and anti‐HCV antibodies were studied in tissue and serum samples taken from patients with non‐Hodgkin's Lymphoma (NHL). The prevalence of HCV, the clinical presentation of these cases, and association with histologic subtypes were determined. RT‐PCR was used to detect the HCV‐RNA in serum and tissue samples. The anti‐HCV antibodies were tested with microparticle enzyme immunoassay. Immunohistochemistry with the ABC method was used to detect the HCV core protein in HCV‐RNA+ cases. RNA could be detected in 30 of 35 cases, and other tests were performed in these 30 samples. HCV‐RNA was detected in 11 tissue samples (11/30, 37%). HCV core protein was studied in 10 of 11 HCV‐RNA+ cases, and 1–3% nuclear staining was found in only 2 samples. Serologically, HCV‐RNA was detected in 7 of 30 samples (23.3%) and anti‐HCV antibody was detected in 3 of 30 samples (10%). Detection of HCV‐RNA in 37% of the lymphoma tissue samples suggests that HCV may have a role or is a contributing factor in the pathogenesis of lymphoma. The very low HCV core protein in lymphoma tissues may be due to the low viral load in lymphoid tissues and/or higher sensitivity of the PCR method. Detection of anti‐HCV antibody in only three cases may be associated with undetectable levels of antibodies due to the immune deficiency in cases with NHL. Am. J. Hematol. 76:252–257, 2004. © 2004 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

et al. 2004

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“…Increasing evidence suggests that the hepatitis C virus (HCV) is the causative agent of the so-called mixed cryoglobulinemia (MC) [1][2][3][4] and that it might be involved in the pathogenesis of B cell non-Hodgkin's lymphomas (NHL) complicating MC 5,6 or arising 'de novo'. 7 On the basis of its prevalence among 537 patients with different lymphoproliferative disorders, 180 with MGUS (monoclonal gammopathy of unknown significance), and 470 with B cell NHL, we previously identified the B cell NHL (in particular the immunocytoma) associated with the production of cryoglobulins (in particular type II), as the probable pathogenetic target of HCV.…”

Section: Introductionmentioning

confidence: 99%

The genotype of the hepatitis C virus in patients with HCV-related B cell non-Hodgkin’s lymphoma

et al. 1997

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Increasing evidence suggests that the hepatitis C virus (HCV) might be involved in the pathogenesis of B cell non-Hodgkin's lymphomas (NHL). Since several HCV genotypes are currently identifiable and might be involved in the pathogenesis of different diseases (with different severity and responsiveness to therapy), the aim of our study was to assess the prevalence of viral genotypes in a group of patients with HCV-related NHL. Among 470 consecutive patients, 42 HCV Ab-positive cases were identified. HCV RNA could be detected by reverse transcriptase-polymerase chain reaction and genotyping performed in 31 of these cases. As compared to our control group (211 healthy blood donors and patients with chronic liver disease), a striking high prevalence of genotype 2ac was detected among B cell NHL (48.4 vs 9.0%), with a relative risk of infection of 5.37 (P Ͻ 0.0001). No major differences were observed in the distribution of NHL histotypes and in the clinical features among patients with genotype 1b (the other most frequent genotype) or 2ac, a part from a trend towards a higher percentage of liver disease and a lower likelihood of response to interferon for patients with genotype 1b. The same high prevalence of genotype 2ac has been recently reported in patients with mixed cryoglobulinemia (MC), monoclonal gammopathies, B cell NHL complicating MC and autoimmune hepatitis. All these data taken together suggest that genotype 2ac might be involved in the pathogenesis of lymphoproliferative and autoimmune disorders.

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“…While mixed cryoglobulins have been described in 50% of patients with chronic HCV infection (l), 53-82% of patients with mixed cryoglobulinemia had chronic HCV infection, and this virus is now considered to be an etiologic agent for mixed cryoglobulinemia (2)(3)(4). Latent autoimmune thyroid disease, glomerulonephritis, polymyositis, and pulmonary fibrosis have been reported in association with HCV (5)(6)(7)(8).…”

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confidence: 99%

Sicca syndrome associated with hepatitis C virus infection

Jørgensen

Legouffe

Perney

et al. 1996

Arthritis & Rheumatism

135

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Objective. To determine the prevalence of hepatitis C virus (HCV) infection in patients with sicca syndrome, and to determine the clinical, immunologic, and genetic characteristics of sicca syndrome associated with HCV.Methods. We conducted a prospective study in a university hospital immunology-rheumatology department. Sixty-two consecutive patients with sicca syndrome according to the European criteria for Sjogren's syndrome were included. HCV infection was diagnosed in patients with positive recombinant immunoblot assay findings and the presence of viral RNA in serum and saliva. Rheumatoid factor (RF), cryoglobulins, antinuclear antibodies, and anti-SS-NSS-B antibodies were sought. HLA typing was performed on all patients.Results. The prevalence of HCV infection in patients with sicca syndrome was 19%. The incidence of neurologic involvement was significantly increased in patients with sicca syndrome associated with HCV infection (24% versus 4%; P c 0.03), as was elevations in transaminase levels (87.5% versus 16%; P < 0.0001). RF and cryoglobulins were more frequent in HCV-positive sicca syndrome patients (62% versus 30%; P C 0.03, and 56% versus 10%; P c 0.001, respectively). In contrast, anti-SS-NSS-B antibodies were present in 38% of HCVnegative sicca syndrome patients, but in only 1 HCVpositive sicca syndrome patient (P c 0.01). No significant difference in HLA type was observed. Viral RNA

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A Role for Hepatitis C Virus Infection in Type II Cryoglobulinemia

Cited by 1,205 publications

References 28 publications

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

Detection of hepatitis C virus RNA in paraffin‐embedded tissues from patients with non‐Hodgkin's lymphoma

The genotype of the hepatitis C virus in patients with HCV-related B cell non-Hodgkin’s lymphoma

Sicca syndrome associated with hepatitis C virus infection

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