A role for eosinophils in transplant rejection

Goldman, Michel; Moine, Alaín Le; Braun, Michel Y; Flamand, Véronique; Abramowicz, Daniel

doi:10.1016/s1471-4906(01)01893-2

Cited by 105 publications

(99 citation statements)

References 35 publications

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“…Although acute rejection is associated generally with T H 1 responses, T H 2-biased inflammation is also capable of mediating acute allograft rejection (71). In the absence of CD8 ϩ T cell alloreactivity, such as in the response of B6 mice to MHC class II-disparate Bm12 skin grafts, numerous eosinophils are found in the inflammatory infiltrate.…”

Section: Cells Of the Innate Immune System As Participants In Allogramentioning

confidence: 99%

The Innate Immune System in Allograft Rejection and Tolerance

LaRosa

Rahman

Turka

2007

The Journal of Immunology

167

121

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As T cells alone are both necessary and sufficient for the rejection of virtually all allogeneic tissues, much of transplantation immunology has focused on cells of the adaptive immune system. During the past decade, advances in our understanding of innate responses to pathogen-associated molecules have spurred a “rediscovery” of innate immunity. Fueled by this, an increasing body of literature has emerged in which the role of the innate immune system in allograft rejection and tolerance has been examined more closely. This review will give an overview of recent studies and emerging concepts of how the cellular components of the innate immune system participate in the immune response to solid organ transplantation. These important studies highlight the complex interplay between diverse cells of the immune response and provide the basis for optimal strategies of tolerance induction.

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Section: Cells Of the Innate Immune System As Participants In Allogramentioning

confidence: 99%

The Innate Immune System in Allograft Rejection and Tolerance

LaRosa

Rahman

Turka

2007

The Journal of Immunology

167

121

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“…A causal role for the Th2/eosinophilic pathway has only recently been observed in the setting of skin and heart rejection where donor and recipients differ at MHC class II Ags, such as the C57BL/6-C57BL/6 bm12 strain combination (47). With regard to minor transplantation Ags, the only evidence to date for the involvement of Th2 cells comes from transfer experiments where Th2-polarized, H-Y-specific CD4 T cell lines were able to reject male H-Y skin grafts (22).…”

Section: Discussionmentioning

confidence: 99%

Skin Graft Rejection Elicited by β2-Microglobulin as a Minor Transplantation Antigen Involves Multiple Effector Pathways: Role of Fas-Fas Ligand Interactions and Th2-Dependent Graft Eosinophil Infiltrates

Surquin

Moine

Flamand

et al. 2002

The Journal of Immunology

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β2-Microglobulin (β2m)-derived peptides are minor transplantation Ags in mice as β2m-positive skin grafts (β2m+/+) are rejected by genetically β2m-deficient recipient mice (β2m−/−). We studied the effector pathways responsible for the rejection induced by β2-microglobulin-derived minor transplantation Ags. The rejection of β2m+/+ skin grafts by naive β2m−/− mice was dependent on both CD4 and CD8 T cells as shown by administration of depleting mAbs. Experiments performed with β2m−/−CD8−/− double knockout mice grafted with a β2m+/+ MHC class I-deficient skin showed that sensitized CD4 T cells directed at β2m peptides-MHC class II complexes are sufficient to trigger rapid rejection. Rejection of β2m+/+ grafts was associated with the production of IL-5 in vitro, the expression of IL-4 and IL-5 mRNAs in the grafted tissue, and the presence within rejected grafts of a considerable eosinophil infiltrate. Blocking IL-4 and IL-5 in vivo and depleting eosinophils with an anti-CCR3 mAb prevented graft eosinophil infiltration and prolonged β2m+/+ skin graft survival. Lymphocytes from rejecting β2m−/− mice also displayed an increased production of IFN-γ after culture with β2m+/+ minor alloantigens. In vivo neutralization of IFN-γ inhibited skin graft rejection. Finally, β2m+/+ skin grafts harvested from B6lpr/lpr donor mice, which lack a functional Fas molecule, survived longer than wild-type β2m+/+ skin grafts, showing that Fas-Fas ligand interactions are involved in the rejection process. We conclude that IL-4- and IL-5-dependent eosinophilic rejection, IFN-γ-dependent mechanisms, and Fas-Fas ligand interactions are effector pathways in the acute rejection of minor transplantation Ags.

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“…Известно, что, как и при болезнях воспаления аллергического типа, эозинофилы могут вызывать повреждение ткани через выделение высоко катионных гранул белка и продукцию некоторых цитокинов, которая способствует воспалению и поляризации Тh 1 (как например IL-1, IL-3, IL-4, IL-5, IL-8, TNF-a) [12]. Хотя острое отторжение ассоциируется в основном с Тh1 ответом, воспаление под влиянием Тh2 также способно опосредовать острое отторжение аллотрансплантата [182]. В отсутствие аллореактивности Т-клеток CD8 + , как, например, при ответе В6-мышей на несовместимые по МНС II Вm12 трансплантаты кожи, в инфильтратах воспаления найдены многочисленные эозинофилы.…”

Section: другие типы клетокunclassified

Role of innate immunity in tolerance induction

2015

BIOMED KHIM

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A role for eosinophils in transplant rejection

Cited by 105 publications

References 35 publications

The Innate Immune System in Allograft Rejection and Tolerance

The Innate Immune System in Allograft Rejection and Tolerance

Skin Graft Rejection Elicited by β2-Microglobulin as a Minor Transplantation Antigen Involves Multiple Effector Pathways: Role of Fas-Fas Ligand Interactions and Th2-Dependent Graft Eosinophil Infiltrates

Role of innate immunity in tolerance induction

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