A role for copper in biological time-keeping

Jiang, Ziying; Morré, Dorothy M.; Morré, D. James

doi:10.1016/j.jinorgbio.2006.08.007

Cited by 10 publications

(19 citation statements)

References 39 publications

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“…Maxima r and s were more widely separated than the others. copper but appear to be inherent in the molecular structure of the Cu II aqua ion [3] itself. Solvated Cu II as the chloride or other salts alone exhibit the property of catalysis of NADH oxidation.…”

Section: Introductionmentioning

confidence: 99%

“…With Cu II Cl 2 , the pattern also consists of 5 maxima, two of which are separated by an interval of 6 min and three which are separated by intervals of 4.5 min. The total period length is 24 min and the period length is independent of temperature and pH [3].…”

Section: Introductionmentioning

confidence: 99%

“…With D 2 O, the period length is extended in proportion to the length of the circadian day which is increased from 24 h to 30 h in organisms grown in D 2 O [5]. D 2 O is the only substance known to so affect both the length of an ultridian biorhythm [3] and the length of the circadian day [5].…”

Section: Introductionmentioning

confidence: 99%

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Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Morré

Orczyk

Hignite

et al. 2008

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Morré

Orczyk

Hignite

et al. 2008

Journal of Inorganic Biochemistry

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“…Organisms grown in D2O consistently exhibit circadian periods of about 30 h compared to the normal period length of 24 h [8]. Further studies revealed a requirement for bound copper II to sustain the periodicity of the ENOX proteins [9,10]. When examined in the absence of protein, copper II hexahydrate in aqueous solution also revealed oscillatory changes in redox potential sufficient to catalyze the oxidation of NADH with a period length of 24 min.…”

Section: Time-keeping Enox Proteinsmentioning

confidence: 94%

“…All ENOX proteins require bound Cu II for activity [9,10]. Activity is lost when the ENOX proteins are unfolded in the presence of the copper chelator bathocuproine and then refolded.…”

Section: Time-keeping Enox Proteinsmentioning

confidence: 99%

Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

Morré¹,

Morré²

2015

Water

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Abstract:A homodimeric, growth-related and time-keeping hydroquinone oxidase (ENOX1) of the eukaryotic cell surface capable of oxidizing intracellular NADH exhibits properties of the ultradian driver of the biological 24 h circadian clock by exhibiting a complex 2 + 3 set of oscillations of copper salts and appear to derive from periodic variations in the ratio of ortho and para nuclear spins of the paired hydrogen atoms of the elongated octahedral structure of the ENOX1 protein bound copper II hexahydrates. A corollary of these observations is that the ortho/para oscillations must occur in a highly synchronized matter. Our findings suggest that water molecules communicate with each other via very low frequency electromagnetic fields and that these fields also appear to be generated by the energetics of the synchronous ortho to para interconversions of the nuclear spin pairs of the water hydrogens. Further evidence for energy absorbed and emitted by water and correlated with ortho/para oscillations of ortho/para spin pairs of water hydrogens is indicated from the auto-oscillations in water luminescence. The emissions oscillate with period lengths of 18.8 min that agree with our previously found period of oscillation of about 18 min for pure water, reflective of ortho to para spin isomers based on measurements of redox potential. The period length of pure water (increased by about 25% in D2O) and varies depending on the dominant cation present (copper salts in solution are unique in that the period length is exactly 24 min). Synchrony is maintained through generation of and response to LFEMF generated by the ortho-para spin pairs. Changes in redox potential sufficient to catalyze NADH oxidation were used to monitor synchronous water oscillations that appear to extend indefinitely over great distances in contiguous bodies of OPEN ACCESSWater 2015, 7 2083 either still or flowing water. Adjacent out-of-phase water samples contained in thin plastic cuvettes auto-synchronize in a matter of seconds when placed side by side. Potential applications from water treatment along with opportunity related to human health are anticipated to derive from a better understanding of how water synchrony is generated and maintained, and to be aided by methodological advances in measurement and analysis.Keywords: oscillations intrinsic to water; oscillations in ortho-para nuclear spins of paired hydrogens of water; time-keeping; water coherence; water treatment; electrodermal sensing

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ENOX Proteins, Copper Hexahydrate-Based Ultradian Oscillators of the Cells’ Biological Clock

Morré

2008

Ultradian Rhythms From Molecules to Mind

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A role for copper in biological time-keeping

Cited by 10 publications

References 39 publications

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Regular oscillatory behavior of aqueous solutions of CuII salts related to effects on equilibrium dynamics of ortho/para hydrogen spin isomers of water

Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

ENOX Proteins, Copper Hexahydrate-Based Ultradian Oscillators of the Cells’ Biological Clock

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