ENOX Proteins, Copper Hexahydrate-Based Ultradian Oscillators of the Cells’ Biological Clock

Morré, D. James

doi:10.1007/978-1-4020-8352-5_2

Cited by 7 publications

(8 citation statements)

References 86 publications

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“…The laser-enhanced auto-oscillations were not observed if water was irradiated beyond the oxygen absorption band or if oxygen was removed from the water. Wavelet transform analysis of the luminescence records indicated two characteristic periods of pulsations of about 300 and 1150 s. These times correspond to the oscillation periods of the concentration ratios of the ortho and para spin isomers of water molecules reported by us [3].…”

Section: Water Luminescence a Results Of Ortho-para Oscillationssupporting

confidence: 82%

“…Maxima labeled ① and ② were phased by exposure to low frequency electromagnetic fields (LFEMF) [14] with synchrony maintained over extended periods of time. The length of the period was independent of temperature suggesting a physical rather than chemical basis as the source of the oscillations [3]. , the period length is reduced from 24 min to about 18 min and maxima ④ and ⑤ are incompletely resolved to yield a 4 maxima pattern with (A) maxima ① and ② separated by 6 min and (B) maxima ③ and ④ separated from each other and from maxima ① and ② by 4 min.…”

Section: Time-keeping Enox Proteinsmentioning

confidence: 93%

“…Chlorides of cations other than Cu II in solution also exhibited oscillations but the period lengths were longer or shorter than those of Cu II [3]. The property of these different cations that correlated with the period length of the oscillations was ionic radii (Figure 9).…”

Section: Oscillations Not Unique To Copper IImentioning

confidence: 98%

“…A link to tie water to cellular time-keeping was the result of the discovery in our laboratory of a family of growth-related cell surface ENOX proteins with alternating NADH oxidase and protein disulfide-thiol interchange that oscillated with a period length of 24 min [2][3][4]. All are located on the external surface of the plasma membrane and are shed into the circulation [5].…”

Section: Time-keeping Enox Proteinsmentioning

confidence: 99%

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Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

Morré¹,

Morré²

2015

Water

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Abstract:A homodimeric, growth-related and time-keeping hydroquinone oxidase (ENOX1) of the eukaryotic cell surface capable of oxidizing intracellular NADH exhibits properties of the ultradian driver of the biological 24 h circadian clock by exhibiting a complex 2 + 3 set of oscillations of copper salts and appear to derive from periodic variations in the ratio of ortho and para nuclear spins of the paired hydrogen atoms of the elongated octahedral structure of the ENOX1 protein bound copper II hexahydrates. A corollary of these observations is that the ortho/para oscillations must occur in a highly synchronized matter. Our findings suggest that water molecules communicate with each other via very low frequency electromagnetic fields and that these fields also appear to be generated by the energetics of the synchronous ortho to para interconversions of the nuclear spin pairs of the water hydrogens. Further evidence for energy absorbed and emitted by water and correlated with ortho/para oscillations of ortho/para spin pairs of water hydrogens is indicated from the auto-oscillations in water luminescence. The emissions oscillate with period lengths of 18.8 min that agree with our previously found period of oscillation of about 18 min for pure water, reflective of ortho to para spin isomers based on measurements of redox potential. The period length of pure water (increased by about 25% in D2O) and varies depending on the dominant cation present (copper salts in solution are unique in that the period length is exactly 24 min). Synchrony is maintained through generation of and response to LFEMF generated by the ortho-para spin pairs. Changes in redox potential sufficient to catalyze NADH oxidation were used to monitor synchronous water oscillations that appear to extend indefinitely over great distances in contiguous bodies of OPEN ACCESSWater 2015, 7 2083 either still or flowing water. Adjacent out-of-phase water samples contained in thin plastic cuvettes auto-synchronize in a matter of seconds when placed side by side. Potential applications from water treatment along with opportunity related to human health are anticipated to derive from a better understanding of how water synchrony is generated and maintained, and to be aided by methodological advances in measurement and analysis.Keywords: oscillations intrinsic to water; oscillations in ortho-para nuclear spins of paired hydrogens of water; time-keeping; water coherence; water treatment; electrodermal sensing

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Section: Water Luminescence a Results Of Ortho-para Oscillationssupporting

confidence: 82%

Section: Time-keeping Enox Proteinsmentioning

confidence: 93%

Section: Oscillations Not Unique To Copper IImentioning

confidence: 98%

Section: Time-keeping Enox Proteinsmentioning

confidence: 99%

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Synchronous Oscillations Intrinsic to Water: Applications to Cellular Time Keeping and Water Treatment

Morré¹,

Morré²

2015

Water

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“…The previously reported 18 min period for water is not an exact value but a trend in period length approximated between 18 and 20 min [5,14,19]. The findings of the present study provide a much more precise value of 18.8 min.…”

Section: Discussioncontrasting

confidence: 60%