A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk+− human lymphoblastoid cells

Morris, Suzanne M.; Domon, Olen E.; McGarrity, Lynda J.; Chen, James J.; Manjanatha, Mugimane G.; Andrews, Annette; Aidoo, Anane; Casciano, Daniel A.

doi:10.1016/0027-5107(96)00095-4

Cited by 17 publications

(4 citation statements)

References 55 publications

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“…When cells are treated with bleomycin, a radiomimetic agent that elicits DNA damage via a free radical mechanism (Morris et al 1996), DNA strand breaks can be detected by comet assay (Hovhannisyan et al 2005; 7 IU/ml [*4 mg/ml] lowest positive concentration), and residual DNA damage following the repair process can be detected by micronucleus formation assay (Aardema et al 2006; 0.11 mg/ml lowest positive concentration). In this study, we detected DNA strand breaks ( Figure 3) and micronucleus formation (Figure 4) induced by treatment with bleomycin alone, but not by exposure to IF magnetic fields at 6.05 mT rms , which suggested that exposure to IF magnetic fields at 6.05 mT rms for 2 h did not cause detectable DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Intermediate frequency magnetic fields generated by an induction heating (IH) cooktop do not affect genotoxicities and expression of heat shock proteins

Sakurai

Kiyokawa

Kikuchi

et al. 2009

TRAB

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Section: Discussionmentioning

confidence: 99%

Intermediate frequency magnetic fields generated by an induction heating (IH) cooktop do not affect genotoxicities and expression of heat shock proteins

Sakurai

Kiyokawa

Kikuchi

et al. 2009

TRAB

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“…Similarly, Mineta et al [1999] concluded that bacterial mutation is not increased by RF radiation. We also examined MN formation following exposure of CHO-K1 cells to IF, using treatment with bleomycin, a radiomimetic agent that elicits DNA damage by a free radical mechanism, as a positive control [Habs and Schmahl, 1984;Morris et al, 1996]. We have previously described the effects of high frequency (2.45 GHz) electromagnetic fields on MN formation in CHO-K1 cells [Koyama et al, 2003], and other studies have shown that a rise in temperature can induce MN formation [Asanami and Shimono, 1997;Komae et al, 1999;Asanami et al, 2001].…”

Section: Discussionmentioning

confidence: 99%

Magnetic fields generated by an induction heating (IH) cook top do not cause genotoxicity in vitro

Miyakoshi

Horiuchi

Nakahara

et al. 2007

Bioelectromagnetics

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The use of induction heater (IH) cook tops in homes has become widespread, especially in Japan, but there are concerns about the safety of intermediate frequency (IF) electromagnetic fields associated with these cooking appliances. Since the cellular genotoxicity of IF magnetic fields has not been examined in cultured cells, we examined the effects of these fields at a magnetic flux density of 532 +/- 20 microT at 23 kHz, using an exposure unit with a built-in CO2 incubator. Exposure to the IF magnetic field at 532 microT for 2 h did not affect the growth of CHO-K1 cells and caused no mutagenic effects in bacterial mutation assays. Exposure to the IF magnetic field for 2 h induced neither single nor double DNA strand breaks in comet assays, and caused no significant change in the mutation frequency at the HPRT locus compared to sham exposure. The magnetic field used in this study is more than 80 times higher than the level recommended as safe in the International Commission on Non-ionizing Radiation Protection (ICNIRP) guidelines. From these results, we suggest that exposure to an IF magnetic field for 2 h does not cause cellular genotoxicity in bacteria and in Chinese hamster cells. However, the possibility of effects on other cellular functions remains, and further studies on the cellular effects of IF magnetic fields are required.

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“…, tumor cells). Unfortunately, ECT often involves not only tumor cells, but also stromal cells [64,65,66].…”

Section: Medical Applications Of Injectable Polysaccharide Hydrogelsmentioning

confidence: 99%

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

Camponeschi

Atrei

Rocchigiani

et al. 2015

Gels

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Polysaccharide-based hydrogels are very promising materials for a wide range of medical applications, ranging from tissue engineering to controlled drug delivery for local therapy. The most interesting property of this class of materials is the ability to be injected without any alteration of their chemical, mechanical and biological properties, by taking advantage of their thixotropic behavior. It is possible to modulate the rheological and chemical-physical properties of polysaccharide hydrogels by varying the cross-linking agents and exploiting their thixotropic behavior. We present here an overview of our synthetic strategies and applications of innovative polysaccharide-based hydrogels: hyaluronan-based hydrogel and new derivatives of carboxymethylcellulose have been used as matrices in the field of tissue engineering; while guar gum-based hydrogel and hybrid magnetic hydrogels, have been used as promising systems for targeted controlled drug release. Moreover, a new class of materials, interpenetrating hydrogels (IPH), have been obtained by mixing various native thixotropic hydrogels. OPEN ACCESSGels 2015, 1 4

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A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk+− human lymphoblastoid cells

Cited by 17 publications

References 55 publications

Intermediate frequency magnetic fields generated by an induction heating (IH) cooktop do not affect genotoxicities and expression of heat shock proteins

Intermediate frequency magnetic fields generated by an induction heating (IH) cooktop do not affect genotoxicities and expression of heat shock proteins

Magnetic fields generated by an induction heating (IH) cook top do not cause genotoxicity in vitro

New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

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