A robust regenerated cellulose-based dual stimuli-responsive hydrogel as an intelligent switch for controlled drug delivery

Song, Fuyu; Gong, Jingwei; Tao, Yehan; Cheng, Yi; Lü, Jie; Wang, Haisong

doi:10.1016/j.ijbiomac.2021.02.104

Cited by 56 publications

(33 citation statements)

References 41 publications

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“…Stimuli-responsive polymers, intelligent materials, change their microstructure according to the surrounding environment including temperature [30,31], pH [32,33], luminance [34,35], and magnetic and electric field fluctuations [36][37][38][39]. The hydrophilicity of a thermo-responsive polymer changes according to the temperature.…”

Section: Development Of Thermo-responsive Hydrogelmentioning

confidence: 99%

Large three-dimensional cell constructs for tissue engineering

Sasaki

Abe

et al. 2021

Science and Technology of Advanced Materials

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Much research has been conducted on fabricating biomimetic biomaterials in vitro. Tissue engineering approaches are often conducted by combining cells, scaffolds, and growth factors. However, the degradation rate of scaffolds is difficult to control and the degradation byproducts occasionally limit tissue regeneration. To overcome these issues, we have developed a novel system using a thermo-responsive hydrogel that forms scaffold-free, three-dimensional (3D) cell constructs with arbitrary size and morphology. 3D cell constructs prepared using bone marrow-derived stromal stem cells (BMSCs) exhibited self-organizing ability and formed bone-like tissue with endochondral ossification. Endothelial cells were then introduced into the BMSC construct and a vessel-like structure was formed within the constructs. Additionally, the bone formation ability was promoted by endothelial cells and cell constructs could be freeze-dried to improve their clinical application. A pre-treatment with specific protein protectant allowed for the fabrication of novel bone substitutes composed only of cells. This 3D cell construct technology using thermo-responsive hydrogels was then applied to other cell species. Cell constructs composed of dental pulp stem cells were fabricated, and the resulting construct regenerated pulp-like tissue within a human pulpless tooth. In this review, we demonstrate the approaches for the in vitro fabrication of bone and dental pulp-like tissue using thermo-responsive hydrogels and their potential applications.

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Section: Development Of Thermo-responsive Hydrogelmentioning

confidence: 99%

Large three-dimensional cell constructs for tissue engineering

Sasaki

Abe

et al. 2021

Science and Technology of Advanced Materials

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“…To avoid the shortcomings of injection and oral administration, it is necessary to design a drug delivery system to deliver MTX into the diseased area to achieve the optimal therapeutic effect[ 9 ]. Various strategies have been developed to control drug delivery using materials such as hydrogels, polymer micelles, and stimulus-responsive materials[ 10 - 12 ]. Three-dimensional (3D) printing technology, known as additive manufacturing (AM), has great potential in fabricating the personalized scaffolds[ 13 - 15 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery

Mei

Gao

et al. 2024

IJB

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In this study, porous polylactic acid/methotrexate (PLA/MTX) scaffolds were successfully fabricated by three-dimensional (3D) printing technology as controllable drug delivery devices to suppress tumor growth. Scanning electron microscopy and energy-dispersive spectrometer confirmed that MTX drug was successfully incorporated into the PLA filament. 3D-printed PLA/MTX scaffolds allow sustained release of drug molecules in vitro for more than 30 days, reducing systemic toxic side effects caused by injection or oral administration. In vitro cytotoxicity assay revealed that PLA/MTX scaffolds have a relatively high inhibitory effect on the tumor cells (MG-63, A549, MCF-7, and 4T1) and relatively low toxic effect on the normal MC3T3-E1 cells. Furthermore, results of in vivo experiments confirmed that PLA/MTX scaffolds highly suppressed tumor growth and no obvious side effects on the organs. All these results suggested that 3D-printed PLA/MTX scaffolds could be used as controllable drug delivery systems for tumor suppression.

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“…Meanwhile, stimuli-responsive degradable materials are important within polymer science and have been used in a wide range of applications spanning medicine and drug delivery to microelectronics and environmental protection. 5 Significantly, macromolecular hydrogels exhibiting macroscopic responses to various bio-stimuli are promising soft materials that have applications in the areas of biosensors, 6 controlled drug release, 7 regenerative medicine, 8,9 etc. More importantly, to visualize the degradation process in real time and achieve the local fluorescence detection of the stimulus analyte as a chemosensor would assist the control of the information delivery in a more precise way.…”

Section: Introductionmentioning

confidence: 99%