3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery

Mei, Yucheng; He, Chengzu; Gao, Chunxia; Zhu, Peizhi; Lu, Guan-Ming; Li, Hong-Mian

doi:10.18063/ijb.v7i4.418

Cited by 26 publications

(10 citation statements)

References 33 publications

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“…Such drug-embedded particles in scaffolds could serve as bioactive implants that exhibit sustained release for tissue repair and regeneration. This strategy also minimizes the exposure of the delivery agent to normal/unaffected tissues while maximizing the effect on diseased cells. , The delivery vehicle-incorporated scaffolds can also be implanted at the surgical site after tumor resection. The bifunctional scaffolds not only provide support and template for new tissue formation but also prevent relapse of the cancer. , The copolymer-loaded 3D DLP-printed scaffolds in the current study have the potential to be used for the aforementioned applications.…”

Section: Resultsmentioning

confidence: 99%

“…This strategy also minimizes the exposure of the delivery agent to normal/unaffected tissues while maximizing the effect on diseased cells. 60,61 The delivery vehicle-incorporated scaffolds can also be implanted at the surgical site after tumor resection. The bifunctional scaffolds not only provide support and template for new tissue formation but also prevent relapse of the cancer.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Core–Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application

Santra,

Prakash,

Maity

et al. 2024

ACS Appl. Mater. Interfaces

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Functionalized ultraviolet photocurable bisphenol A-glycerolate dimethacrylates with tailorable size have been synthesized as the core, which have further been grafted using the diisocyanate chain end of polyurethane (PU) as the shell to create a core−shell structure of tunable size for a controlled drug delivery vehicle. The core−shell structure has been elucidated through spectroscopic techniques like 1 H NMR, FTIR, and UV−vis and their relative shape and size through TEM and AFM morphology. The greater cross-link density of the core is reflected in the higher glass transition temperature, and the improved thermal stability of the graft copolymer is proven from its thermogravimetric analyses. The flow behavior and enhanced strength of the graft copolymers have been revealed from rheological measurements. The graft copolymer exhibits sustained release of the drug, as compared to pure polyurethane and photopolymer, arising from its core− shell structure and strong interaction between the copolymer and drug, as observed through a significant shifting of absorption peaks in FTIR and UV−vis measurements. Biocompatibility has been tested for the real application of the novel graft copolymer in medical fields, as revealed from MTT assay, cell imaging, and cell adhesion studies. The efficacy of controlled release from a graft copolymer has been verified from the gradual cell killing and ∼70% killing in 3 days vs meager cell killing of ∼25% very quickly in 1 day, followed by the increased cell viability of the system treated with the pure drug. The mechanism of slow and controlled drug release from the core−shell structure has been explored. The fluorescence images support the higher cell-killing efficiency as opposed to a pure drug or a drug embedded in polyurethane. Cells seeded on 3D scaffolds have been developed by embedding a graft copolymer, and fluorescence imaging confirms the successful growth of cells within the scaffold, realizing the potential of the core−shell graft copolymer in the biomedical arena.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Core–Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application

Santra,

Prakash,

Maity

et al. 2024

ACS Appl. Mater. Interfaces

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“…Recent research focuses on the development of complex structures combining specific scaffolds with anti-tumor drugs, in order to provide a controllable drug delivery method, with great potential for suppressing tumoral growth. Mei et al describe porous polylactic acid/methotrexate (PLA/MTX) scaffolds obtained using three-dimensional printing technology as drug delivery devices to reduce tumor growth [ 68 ]. Transdermal and topical drug delivery systems are also proposed, with particular relevance in skin cancer treatment.…”

Section: Overview Of Reconstructive Paradigmsmentioning

confidence: 99%

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Grosu-Bularda,

Hodea,

Cretu

et al. 2024

JCM

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The field of plastic surgery is continuously evolving, with faster-emerging technologies and therapeutic approaches, leading to the necessity of establishing novel protocols and solving models. Surgical decision-making in reconstructive surgery is significantly impacted by various factors, including the etiopathology of the defect, the need to restore form and function, the patient’s characteristics, compliance and expectations, and the surgeon’s expertise. A broad surgical armamentarium is currently available, comprising well-established surgical procedures, as well as emerging techniques and technologies. Reconstructive surgery paradigms guide therapeutic strategies in order to reduce morbidity, mortality and risks while maximizing safety, patient satisfaction and properly restoring form and function. The paradigms provide researchers with formulation and solving models for each unique problem, assembling complex entities composed of theoretical, practical, methodological and instrumental elements.

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“…[ 145 ] PLA is also commonly used to print cartilage tissues, [ 146 ] bone tissues, [ 147 ] and construct drug delivery systems. [ 148 ] However, its use is limited because it cannot be used for encapsulating cells.…”

Section: Advances Of Biomaterialsmentioning

confidence: 99%

Recent Advances in Engineering Bioinks for 3D Bioprinting

Wang

Shi

et al. 2023

Adv Eng Mater

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The 3D bioprinting can controllably deposit bioink containing cells and fabricate complex bionic tissue structures in a fast and scalable way, which is expected to completely change the scenario of clinical organ transplantation. Bioprinting holds broad application prospect in tissue engineering, life sciences, and clinical medicine. In the process of 3D bioprinting, bioink, as the carrier of cells and bioactive substances, influences cell activity and accuracy of organ structure after printing. To better understand and design bioink, in this review, the concept, development, and basic composition of bioink are introduced, while focusing on the advantages and disadvantages of various biomaterials, and the use of common cells and biomolecules that constitute bioink. In addition, the properties and applications of various stimuli‐responsive smart materials for 4D bioprinting are mentioned. The challenges and development trends of bioink are also summarized.

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3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery

Cited by 26 publications

References 33 publications

Core–Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application

Core–Shell Structure of Photopolymer-Grafted Polyurethane as a Controlled Drug Delivery Vehicle for Biomedical Application

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Recent Advances in Engineering Bioinks for 3D Bioprinting

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