A Roadmap to the Standardization of In Vivo Magnetic Hyperthermia

Beola, Lilianne; Gutiérrez, Lucía; Grazú, Valeria; Asín, Laura

doi:10.1016/b978-0-12-813928-8.00012-0

Cited by 17 publications

(28 citation statements)

References 69 publications

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“…We have chosen spherical 11 nm iron oxide MNPs (11.2 ± 0.8 nm, Figure ), as this diameter is within the most commonly studied range for in vivo magnetic hyperthermia experiments . This diameter fulfills the requirements for in vivo experimentation, as it avoids fast renal clearance.…”

Section: Resultsmentioning

confidence: 99%

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

Beola

Asín

Fratila

et al. 2018

ACS Appl. Mater. Interfaces

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Magnetic hyperthermia is a promising therapy for the localized treatment of cancer based on the exposure of magnetic nanoparticles to an external alternating magnetic field. In order to evaluate some of the mechanisms involved in the cellular damage caused by this treatment, two different 3D cell culture models were prepared using collagen, which is the most abundant protein of the extracellular matrix. The same amount of nanoparticles was added to cells either before or after their incorporation to the 3D structure. Therefore, in one model, particles were located only inside cells (In model), while the other one had particles both inside and outside cells (In&Out model). In the In&Out model, the hyperthermia treatment facilitated the migration of the particles from the outer areas of the 3D structure to the inner parts, achieving a faster homogeneous distribution throughout the whole structure and allowing the particles to gain access to the inner cells. The cell death mechanism activated by the magnetic hyperthermia treatment was different in both models. Necrosis was observed in the In model while apoptosis in the In&Out model 24 hours after the hyperthermia application. This was clearly correlated with the amount of nanoparticles located inside the cells. Thus, the combination of both 3D models allowed us to

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Section: Resultsmentioning

confidence: 99%

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

Beola

Asín

Fratila

et al. 2018

ACS Appl. Mater. Interfaces

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“…[45] Although magnetic hyperthermia is not yet a routine treatment, clinical trials are ongoing. With the clinical application of magnetic hyperthermia in mind, the following restrictions need to be considered regarding particle design to optimize the heating: [46] (1) focus on biocompatibility [47] and biodegradation: iron oxide nanoparticles are hitherto the only clinically approved heat transducers to be administered to humans. [48] (2) focus on Néel relaxation: iron oxide nanoparticles have to preserve their heating performance when intracellularly immobilized, as in the cellular milieu a physical rotation of nanoparticles, i.e.…”

Section: Designing the Ideal Iron Oxide Nanoparticles For Magnetic Hy...mentioning

confidence: 99%

Embracing Defects and Disorder in Magnetic Nanoparticles

2021

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Iron oxide nanoparticles have tremendous scientific and technological potential in a broad range of technologies, from energy applications to biomedicine. To improve their performance, single‐crystalline and defect‐free nanoparticles have thus far been aspired. However, in several recent studies, defect‐rich nanoparticles outperform their defect‐free counterparts in magnetic hyperthermia and magnetic particle imaging (MPI). Here, an overview on the state‐of‐the‐art of design and characterization of defects and resulting spin disorder in magnetic nanoparticles is presented with a focus on iron oxide nanoparticles. The beneficial impact of defects and disorder on intracellular magnetic hyperthermia performance of magnetic nanoparticles for drug delivery and cancer therapy is emphasized. Defect‐engineering in iron oxide nanoparticles emerges to become an alternative approach to tailor their magnetic properties for biomedicine, as it is already common practice in established systems such as semiconductors and emerging fields including perovskite solar cells. Finally, perspectives and thoughts are given on how to deliberately induce defects in iron oxide nanoparticles and their potential implications for magnetic tracers to monitor cell therapy and immunotherapy by MPI.

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“…The range between these two criteria seems to be currently the most convenient and most used in several in vivo trials [82], at least until new studies about the biological safety of the alternating magnetic field are carried out.…”

Section: Ac-measurements and Slp Evaluationmentioning

confidence: 99%

Specific Loss Power of Co/Li/Zn-Mixed Ferrite Powders for Magnetic Hyperthermia

Barrera

Celegato

Martino

et al. 2020

Sensors

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An important research effort on the design of the magnetic particles is increasingly required to optimize the heat generation in biomedical applications, such as magnetic hyperthermia and heat-assisted drug release, considering the severe restrictions for the human body’s exposure to an alternating magnetic field. Magnetic nanoparticles, considered in a broad sense as passive sensors, show the ability to detect an alternating magnetic field and to transduce it into a localized increase of temperature. In this context, the high biocompatibility, easy synthesis procedure and easily tunable magnetic properties of ferrite powders make them ideal candidates. In particular, the tailoring of their chemical composition and cation distribution allows the control of their magnetic properties, tuning them towards the strict demands of these heat-assisted biomedical applications. In this work, Co0.76Zn0.24Fe2O4, Li0.375Zn0.25Fe2.375O4 and ZnFe2O4 mixed-structure ferrite powders were synthesized in a ‘dry gel’ form by a sol-gel auto-combustion method. Their microstructural properties and cation distribution were obtained by X-ray diffraction characterization. Static and dynamic magnetic measurements were performed revealing the connection between the cation distribution and magnetic behavior. Particular attention was focused on the effect of Co2+ and Li+ ions on the magnetic properties at a magnetic field amplitude and the frequency values according to the practical demands of heat-assisted biomedical applications. In this context, the specific loss power (SLP) values were evaluated by ac-hysteresis losses and thermometric measurements at selected values of the dynamic magnetic fields.

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A Roadmap to the Standardization of In Vivo Magnetic Hyperthermia

Cited by 17 publications

References 69 publications

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

Embracing Defects and Disorder in Magnetic Nanoparticles

Specific Loss Power of Co/Li/Zn-Mixed Ferrite Powders for Magnetic Hyperthermia

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