A rhythmically pulsing leaf-spring nanoengine that drives a passive follower

Centola, Mathias; Poppleton, Erik; Centola, Martin; Valero, Julián; Šulc, Petr; Famulok, Michael

doi:10.1101/2021.12.22.473833

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…We have here used an external electric field to drive the rotor out of equilibrium, as this approach is comparatively easy to implement experimentally. One of the major challenges for future work will be realization of out-of-equilibrium systems by other means, in particular Brownian motors that are fueled by chemical reactions [34, 35].…”

Section: Discussionmentioning

confidence: 99%

From Brownian to deterministic motor movement in a DNA-based molecular rotor

Rothfischer,

Vogt,

Kopperger

et al. 2024

Preprint

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Molecular devices that have an anisotropic, periodic potential landscape can be operated as Brownian motors. When the potential landscape is cyclically switched with a chemical reaction or an external force, such devices can harness random Brownian fluctuations to generate directed motion. Recently, directed Brownian motor-like rotatory movement was demonstrated with an electrically switched DNA origami rotor with designed, ratchet-like obstacles. Here, we demonstrate that also the intrinsic anisotropy of DNA origami rotors that originally were not designed as Brownian motor devices is sufficient to result in motor movement. We show that for low amplitudes of an external switching field such devices operate as Brownian motors, while at higher amplitudes the movement is better described by the deterministic motion of an overdamped electrical motor. We characterize the amplitude and frequency dependence of the movements in both regimes, showing that after an initial steep rise the angular speed peaks and drops for excessive driving amplitudes and frequencies. The characteristics of the rotor movement are well described by a simple stochastic model of the system.

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Section: Discussionmentioning

confidence: 99%

From Brownian to deterministic motor movement in a DNA-based molecular rotor

Rothfischer,

Vogt,

Kopperger

et al. 2024

Preprint

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show abstract

“…Instead, we have to make a decision about whether to accept or reject them. 52 That decision can be complex and emotional, and is often guided by what people in our relevant social networks do, e.g. how many adopt those ideas and behaviours and how many resist them.…”

Section: Complex Contagionmentioning

confidence: 99%

“…However, in complex contagion, Centola has found that strong ties are in fact essential for the spread of ideas, behaviours, and norms, precisely because their adoption requires social confirmation from multiple sources. 56 People are less willing to adopt them unless there is sufficient reinforcement from more than one person in their relevant network. Centola identifies four social mechanisms underpinning these phenomena:…”

Section: Complex Contagionmentioning

confidence: 99%

Online Hate: Is Hate an Infectious Disease? Is Social Media a Promoter?

Popa-Wyatt

2023

J Applied Philosophy

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Our time is marked by a resurgence of hate that threatens to increase oppression. Social media has contributed to this by acting as a medium through which hate speech is spread. How should we model the spread of hate? This article considers two models. First, I consider a simple contagion model. In this model, hate spreads like a virus through a social network. This model, however, fails to capture the fact that people do not acquire hatred from a single infectious contact. Instead, it builds up in a person's beliefs and attitudes through time until the infection reaches a level where the subject themselves becomes a generator of hate speech. Second, to accommodate this, I consider an alternative model known as complex contagion. I argue that not only is a complex contagion model more explanatory and predictive, but it can be used to explain why certain features of social media cause it to be a promoter of hate. I conclude by sketching some mitigation strategies.

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“…(iii) Vesicles containing DNA nanostructures have so-far been demonstrated in equilibrium, which is not consistent with sustaining life. While chemical fuelling of DNA nanostructures has been demonstrated [31][32][33], it requires chemical functionalization or DNA strand displacement reactions [34]. (iv) Finally, the implementation of evolution is not straightforward.…”

Section: Introductionmentioning

confidence: 99%

Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells

Tran,

Chakraborty,

Poppleton

et al. 2024

Preprint

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The central dogma at the core of molecular biology states that information flows from DNA to RNA and then to protein. Our research seeks to introduce a conceptually novel approach towards synthetic life by leveraging RNA origami, as an alternative to proteins, requiring only a single copying step between genetic information and function. Here, we report the genetic encoding and expression of an RNA origami cytoskeleton-mimic within giant unilamellar lipid vesicles (GUVs). We design the first RNA origami tiles which fold co-transcriptionally from a DNA template and self-assemble into higher-order 3D RNA origami nanotubes at constant 37◦C in GUVs, where they reach several micrometers in length. Unlike pre-formed and encapsulated DNA cytoskeletons, these GUVs produce their own molecular hardware in an out-of-equilibrium process fuelled by nucleotide feeding. To establish genotype-phenotype correlations, we investigate how sequence mutations govern the contour and persistence length of the RNA origami nanotubes with experiments and coarse-grained molecular-dynamics simulations, realizing a phenotypic transition to closed rings. Finally, we achieve RNA origami cortex formation and GUV deformation without chemical functionalization by introducing RNA aptamers into the tile design.Altogether, this work pioneers the expression of RNA origami-based hardware in vesicles as a new approach towards active, evolvable and RNA-based synthetic cells.

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A rhythmically pulsing leaf-spring nanoengine that drives a passive follower

Cited by 3 publications

References 48 publications

From Brownian to deterministic motor movement in a DNA-based molecular rotor

From Brownian to deterministic motor movement in a DNA-based molecular rotor

Online Hate: Is Hate an Infectious Disease? Is Social Media a Promoter?

Genetic encoding and expression of RNA origami cytoskeletons in synthetic cells

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