A revised boron-neutron capture therapy for malignant brain tumours

Hatanaka, Hiroshi; Sano, Keiji

doi:10.1007/bf00316011

Cited by 30 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interest in BNCT has been renewed by encouraging results in patients with brain tumours and with malignant melanomas treated with this modality. Hatanaka (1986) reported a 10% 10-year-survival rate for 40 patients with grades 111-IV glioma, in contrast to the results obtained in the 1950s and 1960s during which none survived a year (Farr er nl 1954). Mishima (1990) recently treated five patients with melanoma with our BNCT facility (Matsumoto er al 1989) resulting in successful cure.…”

Section: Introductionmentioning

confidence: 82%

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy

Matsumoto

Aoki²,

Aizawa³

1991

Phys. Med. Biol.

View full text Add to dashboard Cite

In order to determine 10B concentrations in a tumour in vivo without injuring tissues, phantom experiments and calculations were carried out for boron neutron capture therapy. The experiment was based on prompt gamma ray spectroscopy and a single-crystal silicon-filtered neutron beam from a TRIGA-II reactor. Calibration curves to determine the 10B concentrations in the tumours were experimentally generated from known 10B values for simulated tumours with various volumes in a phantom. The 10B distributions in a tumour were also investigated and it was possible to distinguish the tumour with 10B from normal tissue without 10B. In addition, the 10B concentrations were estimated by calculations. A two-dimensional discrete ordinate transport code, DOT3.5, was employed for the calculations of the neutron fluence rate distributions in a phantom. The number of incidental gamma rays entering a germanium detector, which were produced in a tumour as a result of neutron reaction, were calculated by an analytical method. The results were in good agreement with the experiments.

show abstract

Section: Introductionmentioning

confidence: 82%

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy

Matsumoto

Aoki²,

Aizawa³

1991

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

“…The world's first clinical irradiation using BNCT was carried out using a neutron irradiation field installed at a research nuclear reactor in the USA in 1951 [2]. From 1951 until 2012, BNCT has only been performed using reactor-based irradiation systems [3][4][5][6][7][8][9][10][11][12]. At the Kyoto University Research Reactor Institute (KURRI), BNCT clinical studies using a thermal neu- * E-mail: yosakura@rri.kyoto-u.ac.jp; Fax: +81-724-51-2685 tron irradiation facility installed at the Kyoto University Reactor (KUR) came to be regularly performed from February 1990.…”

Section: Introductionmentioning

confidence: 99%

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

Sakurai

Tanaka

Takata

et al. 2015

Journal of the Korean Physical Society

View full text Add to dashboard Cite

At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system. The world's first accelerator-based neutron irradiation system for BNCT clinical irradiation was completed at this institute in early 2009, and the clinical trial using this system was started in 2012. A shift of BCNT from special particle therapy to a general one is now in progress. To promote and support this shift, improvements to the irradiation system, as well as its preparation, and improvements in the physical engineering and the medical physics processes, such as dosimetry systems and quality assurance programs, must be considered.

show abstract

Boron-Neutron Capture Therapy for Tumors

Hatanaka

1991

Glioma

View full text Add to dashboard Cite

A revised boron-neutron capture therapy for malignant brain tumours

Cited by 30 publications

References 6 publications

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

Boron-Neutron Capture Therapy for Tumors

Contact Info

Product

Resources

About

A revised boron-neutron capture therapy for malignant brain tumours

Cited by 30 publications

References 6 publications

Phantom experiment and calculation for in vivo10boron analysis by prompt gamma ray spectroscopy

Phantom experiment and calculation for in vivo10boron analysis by prompt gamma ray spectroscopy

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT

Boron-Neutron Capture Therapy for Tumors

Contact Info

Product

Resources

About

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy

Phantom experiment and calculation for in vivo¹⁰boron analysis by prompt gamma ray spectroscopy