A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper Crocatum Ruiz &amp; Pav)

Suri, Melani Antika; Azizah, Zikra; Asra, Ridho

doi:10.22270/ajprd.v9i1.926

Cited by 16 publications

(19 citation statements)

References 11 publications

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“…Red betel leaf contains as many as 23 components of chemical compounds, including 15 phenolic components, two monoterpenes, three sesquiterpenes, phenolic amide glycosides, neolignanes, and flavonoid c-glycosides [37] [38]. The essential oils in red betel leaf include hydroxycyclicol, chavicols, cavibetol, allylprokatekol, carvacrol, eugenol, p-cymene, cineole, cariofelen, estragole cadimen, terpenes, and phenyl propada [19] [39]. The content of alkaloids, saponins, tannins, and flavonoids contained in this plant is possible to stimulate the process of angiogenesis and the formation of epithelial cells [40][41].…”

Section: Advances In Health Sciences Research Volume 40mentioning

confidence: 99%

“…Rubrum) contained with essential oil has antiseptic activity. A Red betel leaf infusion can heal perineal wounds with less total treatment days compared to betadine [18] [19]. It is possible that the combination of these two herbal ingredients can be used more effectively to accelerate the healing of episiotomy wounds and to reduce the occurence of pain.…”

Section: Introductionmentioning

confidence: 99%

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The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

Emelda¹,

Alfiana²,

Kusumawardani³

et al. 2021

Advances in Health Sciences Research

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The process of episiotomy surgery during childbirth results in injury and pain in the perineum. This study aims to evaluate the effect of the topical combination of cinnamon oil and red betel extract on the healing process of episiotomy incision model in Swiss mice. The research subjects were divided into six groups: (I) Negative control, (II) positive control, (III) mice treated with cinnamon oil, (IV) mice treated with red betel extract, (V) mice treated with 2 ml cinnamon oil and 20% red betel extract, and (VI) mice treated with 4 ml cinnamon oil and 40% red betel extract. Each group of mice received a full-thickness skin wound on the back. The incision wound was then applied by using gel two times a day for 5 days which had been prepared previously. The results showed that the combination of cinnamon oil and red betel decreased the area and percentage of the wound, decreased the inflammatory cell infiltration, and increased the vascular endothelial growth factor expression. This study concludes that the combination of cinnamon oil and red betel extract have the potential to accelerate wound healing and reduce perineal pain in episiotomy incision models conducted in Swiss mice.

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Section: Advances In Health Sciences Research Volume 40mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

Emelda¹,

Alfiana²,

Kusumawardani³

et al. 2021

Advances in Health Sciences Research

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“…The heated leaves often used to relieve asthma, sore throats, coughs and vaginal discharge, while the essential oil used as catarrh and diphteria inhalation and mouthwash, with antifungal activity ability against Candida sphaerospermum and Candida cladospoiroides with strong MIC of 10 μg/ml ( Safithri et al 2020 ; Suri et al 2021 ). The antimicrobial compounds include phenolics and flavonoids in P. crocatum by its hydroxyl group at 5 position caused inner and outer bacterial cell membrane fluidity reduction ( Puspita et al 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…Candida sphaerospermum and Candida cladospoiroides with strong MIC of 10 μg/ml(Safithri et al 2020;Suri et al 2021). The antimicrobial compounds include phenolics and flavonoids in P. crocatum by its hydroxyl group at 5 position caused inner and outer bacterial cell membrane fluidity reduction(Puspita et al 2018).…”

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confidence: 99%

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review

et al. 2023

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Mycoses or fungal infections are general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in Fungi and the incidence of azole antibiotic resistance in the Asia Pacific which reached 83% become a critical problem nowadays. To control fungal infections, substances and extracts isolated from natural resources, especially in the form of plants as the main sources of drug molecules today, are needed. Especially from Piperaceae, which have long been used in India, China, and Korea to treat human ailments in traditional medicine. The purpose of this review is to describe the antifungal mechanism action from Piper crocatum and its phytochemical profiling against lanosterol 14a demethylase CYP51. The methods used to search databases from Google Scholar to find the appropriate databases using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Flow Diagram as a clinical information retrieval method. From 1.150.000 results searched by database, there is 73 final results article to review. The review shows that P. crocatum contains flavonoids, tannins, terpenes, saponins, polyphenols, eugenol, alkaloids, quinones, chavibetol acetate, glycosides, triterpenoids or steroids, hydroxychavikol, phenolics, glucosides, isoprenoids, and non-protein amino acids. Its antifungal mechanisms in fungal cells occur due to ergosterol especially lanosterol 14a demethylase (CYP51) inhibition, which is one of the main target sites for antifungal activity because it functions to maintain the integrity and function of cell membranes in Candida. P. crocatum has an antifungal activity through its phytochemical profiling against fungal by inhibiting the lanosterol 14a demethylase, make damaging cell membranes, fungal growth inhibition, and fungal cell lysis.

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“…Tumbuhan ini mudah tumbuh didaerah tropis sebagai tanaman tradisional penduduk Indonesia. Kandungan kimia daun sirih merah antara lain senyawa flavoid, minyak atsiri, alkaloid, tanin, steroid terpenoid dan saponin (Suri, Azizah and Asra, 2021). Senyawa flavonoid pada sirih merah bersifat antioksidan yang mampu mempercepat penyembuhan luka (Fadlilah, 2015).…”

Section: Pembahasanunclassified

Daun Sirih Merah Sebagai Perawatan Tradisional Dalam Penyembuhan Luka Perineum

Johan,

Noviyanti,

Kustiningsih

et al. 2023

JKDPelamonia

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Perineal tears can occur during labor. This tear causes an injury. This situation can be an entry point for microorganisms that can cause infection if not treated properly. The wound-healing process varies from person to person. However, there are several ways to treat perineal wounds are traditional and non-traditional. This study aimed to determine the perineal wound healing period with red betel leaves. Quasi-experimental research with a posttest-only design approach with non-equivalent groups. In this study, 22 postpartum mothers, the experimental group using red betel leaves, and the control group using clean-dry dressing treatment, which would assess the wound healing process with the REEDA scale. The sampling technique uses accidental sampling. The data analysis used is an independent-Sample T-test. The results, perineal wounds using red betel leaves (5.45 days) were two days faster than dry clean treatment (7.55 days). The REEDA sign was no longer visible in the red betel leaf group on the eighth day. It was still possible to see the control group on the ninth day. Moreover, proper wound care, a healthy diet, and good hygiene contribute to wound healing. Mothers should be confident in their abilities and think positively.

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A Review: Traditional Use, Phytochemical and Pharmacological Review of Red Betel Leaves (Piper Crocatum Ruiz & Pav)

Cited by 16 publications

References 11 publications

The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

The Episiotomy Effect of Topical Combination of Cinnamon Oil and Red Betel on Skin Wound Healing Mechanism

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review

Daun Sirih Merah Sebagai Perawatan Tradisional Dalam Penyembuhan Luka Perineum

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