A Review on Traditional Uses, Phytochemistry, and Pharmacological Activities of Verbascum thapsus

Jan, Fatimah; Jan, Bisma; Dar, Mohd Arif; Sofi, Firdous Ahmad; Alsuwayni, Bashayr; Afzal, Suhaib; Mahomoodally, Mohamad Fawzi

doi:10.1007/978-981-16-4959-2_16

Cited by 3 publications

(2 citation statements)

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“…Mullein has been used in traditional medicine as its leaves and flowers reportedly have analgesic properties [ 61 ]. Interestingly, cigarettes made from V. thapsus have been proposed as a potential remedy for asthma symptoms [ 62 ].…”

Section: Tobacco Alternative Cropsmentioning

confidence: 99%

Alternative Crops for the European Tobacco Industry: A Systematic Review

Mavroeidis,

Stavropoulos,

Papadopoulos

et al. 2024

Plants

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Tobacco (Nicotiana tabacum L.) is a major industrial crop that has being cultivated for centuries for the manufacturing of cigarettes, cigars, and other smoking products. Due to its negative effects on both human health and the environment, the European Union has adopted strict policies that aspire to reduce the consumption of tobacco. Herbal cigarettes are alternative smoking products that are often advertised as healthier than conventional tobacco cigarettes and are especially popular in Asian markets. Even though the available literature suggests that they are equally detrimental to human health, the introduction of tobacco-alternative crops (TACs) to the European tobacco industry could smoothen the abandonment of tobacco, and eventually smoking products altogether, in the EU. The aim of the present systematic review was to compile a list of possible TACs that could be incorporated in the European smoking industry, and highlight their strengths and weaknesses. The most dominant crops in the literature (and in the existing market products) were calendula (Calendula officinalis L.), mullein (Verbascum thapsus L.), ginseng (Panax ginseng C.A.Mey.), tea (Camellia sinensis (L.) Kuntze), chamomile (Matricaria chamomilla L.), and mentha (Mentha spp.). Even though these crops are promising, further research is required for their incorporation in the European tobacco industry.

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Section: Tobacco Alternative Cropsmentioning

confidence: 99%

Alternative Crops for the European Tobacco Industry: A Systematic Review

Mavroeidis,

Stavropoulos,

Papadopoulos

et al. 2024

Plants

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“…It is the largest genus of the family, whose origin has been traced to the center of the Eastern Mediterranean basin (Benedí, 2009). Some species from this genus has been traditionally used to treat a variety of disorders, such as asthma, spasmodic coughs, inflammatory illnesses, diarrhea, migraine headaches, and malaria (Jan et al., 2022). Although these species have been used in traditional medicine since antiquity, their commercial appeal has grown recently, and this growth is being backed up by an increasing number of research studies (Blanco‐Salas et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Verbascum species as a new source of saffron apocarotenoids and molecular tools for the biotechnological production of crocins and picrocrocin

Morote,

Rubio‐Moraga,

López Jiménez

et al. 2023

The Plant Journal

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SUMMARYCrocins are glucosylated apocarotenoids present in flowers and fruits of a few plant species, including saffron, gardenia, and Buddleja. The biosynthesis of crocins in these plants has been unraveled, and the enzymes engineered for the production of crocins in heterologous systems. Mullein (Verbascum sp.) has been identified as a new source of crocins and picrocrocin. In this work, we have identified eight enzymes involved in the cleavage of carotenoids in two Verbascum species, V. giganteum and V. sinuatum. Four of them were homologous to the previously identified BdCCD4.1 and BdCCD4.3 from Buddleja, involved in the biosynthesis of crocins. These enzymes were analyzed for apocarotenogenic activity in bacteria and Nicotiana benthamiana plants using a virus‐driven system. Metabolic analyses of bacterial extracts and N. benthamiana leaves showed the efficient activity of these enzymes to produce crocins using β‐carotene and zeaxanthin as substrates. Accumulations of 0.17% of crocins in N. benthamiana dry leaves were reached in only 2 weeks using a recombinant virus expressing VgCCD4.1, similar to the amounts previously produced using the canonical saffron CsCCD2L. The identification of these enzymes, which display a particularly broad substrate spectrum, opens new avenues for apocarotenoid biotechnological production.

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