A Review on the Recent Research of Polycaprolactone (PCL)

Mohamed, Rabiatul Manisah; Yusoh, Kamal

doi:10.4028/www.scientific.net/amr.1134.249

Cited by 168 publications

(147 citation statements)

References 30 publications

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“…Several reviews have been dedicated to PCL. [7][8][9][10][11][12][13] PCL Safety Is Based on Its Physicochemical Characteristics PCL is biocompatible. In vitro and in vivo tests have been carried out according to state-of-the-art standards (ISO 10993) to evidence the safety of PCL when placed in contact with human tissues and fluids.…”

Section: Polycaprolactone Is a Well-known Polymer Pcl Possesses Specimentioning

confidence: 99%

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Christen¹,

Vercesi²

2020

CCID

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Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. PCL is biocompatible and biodegradable. Its specific physicochemical and mechanical properties, viscoelasticity and ease of shaping led to the production of PCL-based products with various shapes and durations dependent on its biodegradation kinetics. PCL has been safely used in the biomedical field for more than 70 years, from sutures to tissue and organ replacement by 3D printing. The PCL-based collagen stimulator is composed of PCL microspheres suspended in a carboxymethyl-cellulose gel carrier providing immediate and sustained volumizing effects when injected; the morphology, the biocompatibility of the PCL microspheres embedded with the collagen fibers produced all contribute to the creation of a unique 3D scaffold for a sustained effect. Its safety has been investigated in clinical studies and vigilance surveys. Recently published experts' recommendations on injection modalities and techniques should help further optimize treatment outcome and safety. This paper also integrates reviews and recommendations on the prevention and management of adverse events related to dermal and subdermal fillers including the PCL-based collagen stimulator. In addition, in terms of efficacy and safety, this product benefits from its daily clinical use in esthetics worldwide and continuous extensive fundamental and clinical research, both on it and the PCL polymer. Forthcoming data from further investigations will reinforce knowledge of the product and procedures in the field.

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Section: Polycaprolactone Is a Well-known Polymer Pcl Possesses Specimentioning

confidence: 99%

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Christen¹,

Vercesi²

2020

CCID

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“…7 It is a hydrophobic, semicrystalline polymer and its crystallinity tends to decrease as its molecular weight increases. 8 Because of its high crystallinity and high hydrophobicity, it degrades at a much slower rate than PLA. 6 PCL has also been approved by the FDA for clinical applications, and is extensively used in lots of biomedical applications due to the proper tensile property and biocompatibility, 9,10,11,12 pure or in combination with other polyesters in order to modulate its degradation kinetics.…”

Section: Introductionmentioning

confidence: 99%

PLA/PCL electrospun membranes of tailored fibres diameter as drug delivery systems

Herrero-Herrero

Gómez-Tejedor

Vallés-Lluch

2018

European Polymer Journal

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The main electrospinning parameters, i.e., polymer concentration in the injectable solution, solvents used and their proportion, flow rate, voltage and distance to collector were herein systematically modified to analyse their particular influence in fibres diameter of electrospun membranes of poly(lactic acid), polycaprolactone and their mixture. As a result of this analysis, the procedures to obtain membranes of these polymers and blend with under-and above-micron-sized fibres were established, in which the solvents ratio (chloroform/methanol and dichloromethane/dimethylformamide) and voltage were found to play the major role. Moreover, the plausible differential effect of these fibres diameters (0.8 and 1.8 µm) in the controlled release of a molecule of interest was explored, using bovine serum albumin (BSA), proving that the most effective configuration for BSA release among those studied was the PLA-PCL combination in membranes of above-micron fibres diameter.

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“…Poly(ε‐caprolactone) (PCL) has a high degree of crystallinity, a slow rate of degradation, and significant viscoelastic and rheological properties . It is often utilized for a biodegradable polymer plasticizer as a result of its linear structure.…”

Section: Synthesis Of Polyhydroxyalkanoatesmentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

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In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.

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A Review on the Recent Research of Polycaprolactone (PCL)

Cited by 168 publications

References 30 publications

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

PLA/PCL electrospun membranes of tailored fibres diameter as drug delivery systems

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

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