A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective

Wsoo, Mohammed Ahmad; Shahir, Shafinaz; Bohari, Siti Pauliena Mohd; Nayan, Nadirul Hasraf Mat; Razak, Saiful Izwan Abd

doi:10.1016/j.carres.2020.107978

Cited by 146 publications

(81 citation statements)

References 120 publications

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“…the tensile strength/Young’s modulus values of cellulose eNFs could be increased by heat/chemical treatment, because during heat treatment eNFs gets crosslinked, so reaching at crossover points will lead to the bonding of nanofibers [ 89 ].…”

Section: Figurementioning

confidence: 99%

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An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Section: Figurementioning

confidence: 99%

“…in vitro degradation and drug release study revealed that cellulose eNFs are absorbable-degradable barriers, so they are prospective bio-degradable drug release devices [ 89 ].…”

Section: Figurementioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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“…For example thiolated cellulose has a higher affinity toward proteins, due to the presence of thiol binders [ 125 ]. Methyl and ethyl celluloses are hydrophobic, while both acetate and hydroxypropyl cellulose are water-soluble [ 127 ]. These derivatives can be used in the design of smart delivery architectures, including films, electrospun fibers, and coatings, for biomedical applications.…”

Section: Principal Polysaccharides Used For Biomedical Materialsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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“…12,13 Moreover, polymerics can also circulate for a long time and preferentially accumulate in tumour sites via the enhanced permeability and retention (EPR) effect. 14,15 Active targeting technology has taken advantage of ligand-receptor, antigenantibody, and other forms of molecular recognition to deliver particles or drugs to a specic location. 16 For instance, a variety of macromolecules and small organic molecules with special functions were composed of molecule tumour-targeting receptors (e.g., biotin or folic acid).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of biotin-conjugated Portulaca oleracea polysaccharides

et al. 2021

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A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective

Cited by 146 publications

References 120 publications

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Synthesis and biological evaluation of biotin-conjugated Portulaca oleracea polysaccharides

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