A Review on Synthesis and Pharmacological Activity of Coumarins and Their Analogs

Abstract

The biological, therapeutic and medicinal properties of coumarins and its analogs have prompted enormous research aimed at developing synthetic routes to these heterocycles. This review presents a systematic and comprehensive survey of the method of preparation, the chemical reactivity and biological properties associated with this system.

Naturally Occurring Antioxidants in Seven Well-Known Fruits from the Republic of Suriname (South America): Part 1

“…Some of these traditional uses are in accordance with the results from the abovementioned pharmacological studies with coumarin analogues-from the seed as well as other parts of the plant-showing a wide range of pharmacological activities [180][181][182]. This suggests that at least some of the traditional uses of D. odorata seed preparations are also attributable to antioxidant activities.…”

“…Besides anticoagulant activity, coumarins have been found to elicit a host of other pharmacological activities including antitumor, photochemotherapeutic, anti-HIV, antimicrobial, anti-inflammatory, triglyceride-lowering, central nervous systemstimulating, and menopausal distress-preventing effects [180][181][182]. These beneficial health effects are believed to be mainly related to their antioxidant activities, providing protection against oxidative stress by scavenging ROS such as superoxide, hypochlorous acid, and hydroxyl radicals [183].…”

Recent progress on coumarinscaffold‐basedanti‐microbial agents (PartIII)

“…[ 56,57 ] In view of all these facts and because of the continuation of our paintings on the synthesis of latest heterocyclic derivatives. [ 58‐65 ] The present review showed a broad view of the anti‐microbial properties expressed by compounds having a coumarin nucleus.…”

Hetarenocoumarins based on 7-hydroxy-3-(benzothiazol-2-yl)coumarin

“…naturally in many plants and find wide use in medicine due to their diverse pharmacological activities [1,2]. They possess excellent photophysical properties such as high quantum yield, strong fluorescence, and high photostability, and therefore are used as dyes for biosensitization and biomarking [3].…”