A Review on Surface Modifications and Coatings on Implants to Prevent Biofilm

Pichika, S V V S Narayana; P., S. V. V. Srihari

doi:10.1007/s40883-019-00116-3

Cited by 26 publications

(6 citation statements)

References 226 publications

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“…From a clinical point of view, there is a considerable relationship between the ability to form biofilms and resistance to conventional antibiotics (Sharma et al, 2019).According to the National Institute of Health, in humans, biofilms account for up to 80% of the total bacterial infections, including endocarditis, periodontitis, sinusitis, meningitis, osteomyelitis, chronic wounds, and prosthesis and implantable devices related infections (Khatoon et al, 2018). In many of these cases, infection arises from implantable medical devices, such as catheters, implants, and implantable electronic devices (Khatoon et al, 2018;Narayana and Srihari, 2019;Pelling et al, 2019) that become contaminated with bacteria, usually biofilms of staphylococci, streptococci, Gram-negative bacteria, and fungi (Kokare et al, 2009;Marks et al, 2014b;Rosini and Margarit, 2015;Gomes et al, 2016;Young et al, 2016;Castilho et al, 2017;Stewart and Bjarnsholt, 2020).…”

Section: Clinical and Veterinary Relevance Of Pyogenic Biofilmmentioning

confidence: 99%

Singularities of Pyogenic Streptococcal Biofilms – From Formation to Health Implication

et al. 2020

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Biofilms are generally defined as communities of cells involved in a self-produced extracellular matrix adhered to a surface. In biofilms, the bacteria are less sensitive to host defense mechanisms and antimicrobial agents, due to multiple strategies, that involve modulation of gene expression, controlled metabolic rate, intercellular communication, composition, and 3D architecture of the extracellular matrix. These factors play a key role in streptococci pathogenesis, contributing to therapy failure and promoting persistent infections. The species of the pyogenic group together with Streptococcus pneumoniae are the major pathogens belonging the genus Streptococcus, and its biofilm growth has been investigated, but insights in the genetic origin of biofilm formation are limited. This review summarizes pyogenic streptococci biofilms with details on constitution, formation, and virulence factors associated with formation.

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Section: Clinical and Veterinary Relevance Of Pyogenic Biofilmmentioning

confidence: 99%

Singularities of Pyogenic Streptococcal Biofilms – From Formation to Health Implication

et al. 2020

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“…Thus, preventing biofilm formation is essential to reducing the risk of post-operative infection [6]. Consequently, there are different strategies toward bacterial biofilm, including surface modification of medical devices/implants [7], small molecule biofilm inhibitors [8], biofilm dispersal agents [9], and antibacterial coatings [10,11]. Antibacterial coatings may prevent biofilm formation and prevent inflammation [2,12] and are employed to locally deliver antibiotic drugs and therapeutic agents for short-(few hours or days) or long-acting antibacterial effects (days and weeks) [13].…”

Section: Introductionmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

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“…There have been multiple countermeasures against bacterial biofilms which mostly revolve around surface coatings with various functions: from antiadhesion, interfering, to inactivation . The majority of them involve chemically bactericidal approaches, such as localized drug administration or polymeric self-dispersal agents.…”

Section: Introductionmentioning

confidence: 99%

Preventing Static Biofilm Formation of Staphylococcus aureus on Different Types of Surfaces Using Microbubbles

Le,

Tran,

et al. 2024

Langmuir

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Bacterial fouling and biofilm formation on surfaces have been ongoing problems in real life as well as in the medical field. Different approaches have been taken to tackle the issues, from costly surface modification to antibiotic-delivering strategies. In this study, we examined the potential of using stabilized microbubbles (MBs) to shield against bacterial adhesion. Three types of surfaces were tested: hydrophilic glass (hydrophilic surface), neutral hydrophobic polystyrene (PS)-coated surfaces, and negatively charged hydrophobic octadecyltrichlorosilane (OTS)-coated surfaces. By evaluating the colony-forming unit (CFU) values from each surface, MBs stabilized by 0.05 mM SDS were shown to only produce significant reduction of Staphylococcus aureus adhesion on PS surfaces, up to 60.29 and 82.32% compared to no-MB PS surfaces, and no-MB uncoated surfaces, correspondingly, due to the appropriate size, stability, and negative charges of the MB shielding layer. On the other hand, OTS coatings had an intrinsic antiadhesion effect (69.83% compared to uncoated surface), given that the negatively charged OTS-aqueous interface or surface porosity nature of the coating prohibited the attachment of MBs, leading to the elimination of the antifouling effect of MBs. Ultimately, MBs gave better shielding results than surface modification when compared to uncoated surfaces and hence can be applied more widely.

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A Review on Surface Modifications and Coatings on Implants to Prevent Biofilm

Cited by 26 publications

References 226 publications

Singularities of Pyogenic Streptococcal Biofilms – From Formation to Health Implication

Singularities of Pyogenic Streptococcal Biofilms – From Formation to Health Implication

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Preventing Static Biofilm Formation of Staphylococcus aureus on Different Types of Surfaces Using Microbubbles

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