A Review on Salient Pharmacological Features of Momordica charantia

Upadhyay, Aparna; Agrahari, Pooja; Singh, Dinesh

doi:10.3923/ijp.2015.405.413

Cited by 37 publications

(14 citation statements)

References 58 publications

(57 reference statements)

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“…The plant is composed of 83.2% moisture, 2.9% protein, 1% fat, 9.8% carbon, 1.7% fiber, 1.4% mineral and organic substances (calcium, phosphorus, iron, carotene, thiamine, nicotinic acid, riboflavin, ascorbic acid, copper and potassium) [6]. Bitter melon contains high amounts of vitamin C, as well as vitamin A, β-carotene, α-carotene, potassium, magnesium and zinc.…”

Section: Introductionmentioning

confidence: 99%

Comparison of antioxidant capacities and antioxidant components of commercial bitter melon (Momordicacharantia L.) products

Akyüz

TÜrkoĞlu²,

Başkan

et al. 2020

Turk J Chem

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In this study, the total phenolic contents and total antioxidant capacities of some commercial bitter melon products (powder, packaged powder, capsule, paste in olive oil), and of unripe and ripe fruits were determined by spectrophotometric and chromatographic methods. The total antioxidant capacities of unripe and ripe bitter melon samples, determined by CUPRAC (Cupric Reducing Antioxidant Capacity Assay) and ABTS (2,2′-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid)/HRP (Horseradish peroxidase) methods, were 42.5 and 36.3 µmol TRE (trolox equivalent) g-1 , 8.7 and 7.0 µmol TRE g-1 , respectively. The TAC (total antioxidant capacity) order of studied samples using the same two methods were determined as follows; capsule (CUPRAC value, 140.8; ABTS/HRP value, 143.6 µmol TRE g-1) > packaged powder (129.6; 126.1) 2 > powder (52.3; 64.3) > unripe fruit (42.5; 36.3) > paste in olive oil (17.6; 14.4) > ripe 25 fruit (8.7; 7.0). Their order of phenolic content was found as follows; unripe fruit (193.2 26 µmol GAE (gallic acid equivalent) g-1) > capsule (162.0) > packaged powder (160.6) > 27 powder (83.6) > paste in olive oil (38.3) > ripe fruit (14.6).

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Section: Introductionmentioning

confidence: 99%

Comparison of antioxidant capacities and antioxidant components of commercial bitter melon (Momordicacharantia L.) products

Akyüz

TÜrkoĞlu²,

Başkan

et al. 2020

Turk J Chem

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“…charantia is widely cultivated in Asia, Africa, and South America and it has been used extensively in folk medicines for the treatment of diabetes mellitus (Figure 1 Mo). 18 M. charantia contains a number of chemical compounds including nutritionally important vitamins and minerals, antioxidants, and many other phytochemicals, that include: saponins, phenolic constituents, glycosides, fixed oils, alkaloids, resins, reducing sugars, and free acids. M. charantia is a good source of vitamins A and C, iron, phosphorus, protein (440-780 mg/kg), carbohydrates, zinc, calcium, and magnesium.…”

Section: Structure and Componentsmentioning

confidence: 99%

Possible molecular mechanisms of glucose‐lowering activities of Momordica charantia (karela) in diabetes

Pahlavani

Roudi

Zakerian³

et al. 2019

J of Cellular Biochemistry

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Diabetes mellitus is a highly prevalent metabolic disorder which is characterized by impaired glucose tolerance, with a relative or absolute insulin deficiency and profound changes in the metabolism of macronutrients. Traditional and complementary medicine is therapeutic strategies that have both been applied to improving glycemic control. Momordica charantia is one of the plant-based, folk medicines that used for improving glycemic control. We aimed to review, the effects of M. charantia on blood glucose with a clarification of the molecular pathways involved. Of the compounds derived from the plants, the insulin-like peptide, charantin, and the alkaloid vicine, have been reported to have hypoglycemic effects. Different mechanisms contribute to the antidiabetic activities of M. charantia, these include increasing pancreatic insulin secretion, decreasing insulin resistance and increasing peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption and suppressing of key enzymes in the gluconeogenic pathways.

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“…Seed: The seed is 8–15 mm long black but covered with a soft, flesh white in unripe to red in ripe [ Figure 1 ]. [ 10 11 ]…”

Section: Plant Description Of Momordica Charantiamentioning

confidence: 99%

An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Poolperm¹,

Jiraungkoorskul²

2017

Phcog Rev

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Momordica charantia (Family: Cucurbitales), as known as bitter melon or gourd, is a daily consumption as food and traditional medicinal plant in Southeast Asia and Indo-China. It has been shown to possess anticancer, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity, antioxidant, and antiulcer properties. Its common phytochemical components include alkaloids, charantin, flavonoids, glycosides, phenolics, tannins, and terpenoids. This plant is rich in various saponins including momordicin, momordin, momordicoside, karavilagenin, karaviloside, and kuguacin, all of which have been reported to contribute to its remedial properties including antibacterial, antifungal, antiviral, and antiparasitic infections. Based on established literature on the anthelmintic activity of M. charantia and possible mode of action, this review article has attempted to compile M. charantia could be further explored for the development of potential anthelmintic drug.

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A Review on Salient Pharmacological Features of Momordica charantia

Cited by 37 publications

References 58 publications

Comparison of antioxidant capacities and antioxidant components of commercial bitter melon (Momordicacharantia L.) products

Comparison of antioxidant capacities and antioxidant components of commercial bitter melon (Momordicacharantia L.) products

Possible molecular mechanisms of glucose‐lowering activities of Momordica charantia (karela) in diabetes

An update review on the anthelmintic activity of bitter gourd, Momordica charantia

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