An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Poolperm, Sutthaya; Jiraungkoorskul, Wannee

doi:10.4103/phrev.phrev_52_16

Cited by 31 publications

(8 citation statements)

References 38 publications

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“…Various types of traditional plants for medical use have been studied to obtain extracts that present potential antiparasitic activity. Hence, the anthelmintic activity of M. charantia has been registered in in-vitro and in-vivo trials and by phytochemical analyses in other latitudes (30)(31)(32). M. charantia is known as "the bitter melon" and belongs to the Cucurbitaceae family (33).…”

Section: H Contortus and H Placei Have Been Reported Inmentioning

confidence: 99%

In-vitro effect of the methanolic extract of Momordica charantia on hatching of eggs of Haemonchus sp.

Hernández

Vásquez-Trujillo

Rodríguez

2021

Vitae

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Background: Endoparasitism, particularly infections by gastrointestinal nematodes (e.g., Haemochus sp.), has been associated with economic losses within sheep production systems in tropical regions. Thus, implementing therapeutic alternatives that are environmentally sustainable is essential for parasite integral control programs. Objectives: Evaluate in-vitro the effect of Momordica charantia methanolic extract on the Haemonchus sp. eggs' hatching process. Methods: Nematode eggs were retrieved from experimentally infected sheep and exposed to 10, 20, 40, 80, and 160 mg/mL of methanolic extract of M. charantia. Hatching percentages were recorded from five replicates, and CL50 and CL90 were estimated through Probit regression analysis. Results: A significant effect on the hatching percentages were observed, from 24.2% up to 84.6% inhibition (p<0.05). The LC50 and LC90 estimated were 52.2 mg/mL (95%CI 37.87-63.22) and 201.45 mg/mL (95%CI 186.01-221.89), respectively. Utilizing a preliminary phytochemical analysis, potential antihelmintic compounds such as alkaloid, triterpenes, and anthracenic glycosides groups were identified in the methanolic extract. Conclusions: In the in-vitro test, the methanolic extract of M. charantia was effective in inhibiting the hatching of Haemonchus sp., which is important to promote other bio-guided fractionation studies of this plant on different life stages of H. contortus, this being a plant species widely adapted to the conditions of the piedmont (foothills) of Meta, Colombia.

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Section: H Contortus and H Placei Have Been Reported Inmentioning

confidence: 99%

In-vitro effect of the methanolic extract of Momordica charantia on hatching of eggs of Haemonchus sp.

Hernández

Vásquez-Trujillo

Rodríguez

2021

Vitae

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“…The plant of Momordica charantia is also rich in numerous saponins including kuguacin, momordicin, karaviloside, momordin, momordicoside, and karavilagenin. [33] In one study, the obese rats fed on bitter melon continued to live at least a month longer as compared to control. [34] Owing to these functional components, bitter melon possess wide range of pharmacological activities for instance, antioxidant, [32] antifungal, [35] antidiabetic, [36] ant obesity, stomachic, anticancer, hypotensive, and blood cholesterol lowering effects.…”

Section: Therapeutic Usementioning

confidence: 99%

Bitter melon (Momordica charantia): a natural healthy vegetable

Saeed

Afzaal

Niaz

et al. 2018

International Journal of Food Properties

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Bitter melon provides health benefits against various ailments for improving the quality of life. It is nutrient dense plant-based food containing versatility of bioactive compounds such as alkaloids, polypeptide, vitamins, and minerals. Owing to presence of bioactive compounds, it has the ability to fight against various lifestyle related disorders, e.g. cancer insurgence, diabetes mellitus, abdominal pain, kidney (stone), fever, and scabies. Amongst bioactive moieties, p-insulin is similar to insulin whose subcutaneous injection significantly lower blood glucose levels in diabetic patients. It also contains steroidal saponins called charantin, act alike peptides and certain alkaloids that effectively control sugar level in blood. The therapeutic perspectives have been also highlighted as they are helpful in regulating blood cholesterol thus protecting the body from cardiovascular disorders like atherosclerosis. Whole fruit, seeds and leaves of bitter melon regulates impaired antioxidant status and suppress fat accumulation. Moreover, curative potential of its bioactive components and their utilization in value added food products are also the limelight of article.

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“…Tanaman ini mempunyai umur panen yang sangat genjah, kandungan biokimia dan nutrisi bermanfaat bagi manusia berupa 20-25% pati, 4-10% gula, 0,6 -1,5% lemak, dan 2-4% mineral dapat berperan penting untuk memenuhi defisiensi nutrisi (Mahmud, 2017). Pada biji ercis terdapat senyawa bioaktif atau sifat fitokimia, anti-bakteri, anti-Helicobacter pylori, anti-kanker, anti-diabetes, antijamur, anti-inflamasi, aktivitas antilipidemik dan antioksidan (Poolperm & Jiraungkoorskul, 2017). Secara ekologis, tanaman ercis dapat menunjang pertanian berkelanjutan karena tanaman ini merupakan salah satu jenis tanaman legume yang mampu mengikat N dari udara sehingga meningkatkan kesuburan tanah dan dapat digunakan sebagai tanaman rotasi (Bourgault et al, 2016;Gebreslassie & Abraha, 2016).…”

Section: Pendahuluanunclassified

Keanekaragaman genotipe-genotipe potensial dan penentuan keragaman karakter agro-morfologi ercis (Pisum sativum L.)

Saragih

Saptadi

Zanetta

et al. 2018

J. AGRO

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Ercis (Pisum sativum L.) merupakan salah satu tanaman kacang komersial yang penting di dunia termasuk di Indonesia. Ercis lokal merupakan sumber populasi untuk meningkatkan kapasitas genetik hasil panen polong dan biji melalui seleksi galur murni. Tujuan penelitian ini untuk mempelajari jarak dan keanekaragaman genetik, serta keragaman karakter 37 genotipe potensial ercis hasil seleksi galur murni varietas lokal. Penelitian dilaksanakan pada bulan Maret hingga Juni 2018 di Desa Pendem, Kecamatan Junrejo, Kota Batu. Percobaan menggunakan rancangan acak kelompok dengan 37 genotipe sebagai perlakuan dan diulang tiga kali, sehingga terdapat 111 satuan percobaan. Pengamatan dilakukan pada masing-masing tanaman yakni karakter agronomi dan morfologi. Pengelompokan genetik didasarkan pada agglomerative hierarchical clustering dengan similiritas koefisien kolerasi Pearson dan metode aglomerasi unweighted pair group method average (UPGMA). Keanekaragaman genetik didasarkan pada indeks Shannon-Wiener (H’) dan indeks Shimpson (D). Keragaman karakter agronomi dan morfologi 37 genotipe ercis menggunakan principal component analysis (PCA) dengan pendekatan tipe korelasi Pearson. Berdasarkan analisis klaster 37 genotipe ercis terbagi menjadi 6 kelompok berdasarkan 61 karakter agro-morfologi dengan koefisien kemiripan 89-99%. Diversitas genetik ercis dikategorikan sedang dengan nilai indeks Shanon-Wiener 1,5 dan nilai indeks Simpson 0,26 yang menunjukkan tidak terdapat kelompok genetik yang mendominansi. Tiga puluh tujuh genotipe ercis memiliki keragaman yang luas. Keragaman kumulatif berdasarkan 61 karakter agro-morfologi yang diamati mencapai 87,83% yang melibatkan 44 karakter pada 16 komponen utama pertama.Pea (Pisum sativum L.) is one of the important commercial legumes in the world, including in Indonesia. The aims of the research were to study genetic distance, diversity, and characters variability of 37 genotypes of pea. The experiment was conducted on March to June 2018 in Pendem, Junrejo, Batu City. The experimental design used a randomized block design with 37 genotypes as treatments and replicated three times. Observations was made on agronomic and morphological characters. Genetic grouping according to agglomerative hierarchical clustering with Pearson correlation coefficient similarity and unweighted pair group average agglomeration method (UPGMA). Genetic diversity based on Shannon-Wiener (H') index and Shimpson (D) index. Variability of agronomic and morphological characters in 37 genotypes was analyzed by principal component analysis (PCA) with Pearson correlation approach. The results showed that cluster analysis of 37 genotypes was divided into six groups in 61 agro-morphological characters with similarity coefficients of 89-99%. Genetic diversity was medium categorized with Shanon-Wiener index value of 1.5 and Simpson index value of 0.26. It was indicated that no dominating on genotypes group. Thirty seven genotypes of pea showed high variability. Cumulative variability on 61 observed agro-morphological characters reached 87.83% which involved 44 characters in 16 first principal components.

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An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Cited by 31 publications

References 38 publications

In-vitro effect of the methanolic extract of Momordica charantia on hatching of eggs of Haemonchus sp.

In-vitro effect of the methanolic extract of Momordica charantia on hatching of eggs of Haemonchus sp.

Bitter melon (Momordica charantia): a natural healthy vegetable

Keanekaragaman genotipe-genotipe potensial dan penentuan keragaman karakter agro-morfologi ercis (Pisum sativum L.)

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