A review on role of prakriti in aging

BackgroundAyurveda, an ancient Indian medicinal system, has categorized human body constitutions in three broad constitutional types (prakritis) i.e. Vata, Pitta and Kapha.ObjectivesAnalysis of plasma metabolites and related pathways to classify Prakriti specific dominant marker metabolites and metabolic pathways.Materials and methods38 healthy male individuals were assessed for dominant Prakritis and their fasting blood samples were collected. The processed plasma samples were subjected to rapid resolution liquid chromatography–electrospray ionization–quadrupole time of flight mass spectrometry (RRLC–ESI–QTOFMS). Mass profiles were aligned and subjected to multivariate analysis.ResultsPartial least square discriminant analysis (PLS-DA) model showed 97.87% recognition capability. List of PLS-DA metabolites was subjected to permutative Benjamini–Hochberg false discovery rate (FDR) correction and final list of 76 metabolites with p < 0.05 and fold-change > 2.0 was identified. Pathway analysis using metascape and JEPETTO plugins in Cytoscape revealed that steroidal hormone biosynthesis, amino acid, and arachidonic acid metabolism are major pathways varying with different constitution. Biological Go processes analysis showed that aromatic amino acids, sphingolipids, and pyrimidine nucleotides metabolic processes were dominant in kapha type of body constitution. Fat soluble vitamins, cellular amino acid, and androgen biosynthesis process along with branched chain amino acid and glycerolipid catabolic processes were dominant in pitta type individuals. Vata Prakriti was found to have dominant catecholamine, arachidonic acid and hydrogen peroxide metabolomics processes.ConclusionThe neurotransmission and oxidative stress in vata, BCAA catabolic, androgen, xenobiotics metabolic processes in pitta, and aromatic amino acids, sphingolipid, and pyrimidine metabolic process in kapha Prakriti were the dominant marker pathways.

Section: Discussionmentioning

confidence: 99%

Plasma metabolomics reveal the correlation of metabolic pathways and Prakritis of humans

Shirolkar

Chakraborty

Mandal³

et al. 2018

“…Pitta -dominant individuals tend to experience more ulcers, bleeding disorders, and skin diseases [22]. In aging investigations, Pitta -dominant individuals had a higher basal metabolic rate and energy usage which predisposes such individuals to greater tissue loss and premature aging compared to Kapha individuals who tended toward delayed aging [23]. Studies correlating metabolic differences among Prakruti types with metabolic markers have revealed that Pitta -dominant individuals are fast- and Kapha-dominant individuals are slow-metabolizers based on drug metabolizing enzyme markers.…”

Section: Discussionmentioning

confidence: 99%

Relationships among classifications of ayurvedic medicine diagnostics for imbalances and western measures of psychological states: An exploratory study

Mills

Peterson

Wilson

et al. 2019

BackgroundAccording to Ayurveda, the traditional medical system of India, doshas are a combination of characteristics based on a five-element philosophy that drive our mental and physical tendencies. When the doshas, or functional principles, are out of balance in quality or quantity, wellbeing is adversely affected and symptoms manifest.ObjectiveThis study examined relationships among imbalances in the doshas (termed Vikruti) reported via questionnaire and Western measures of psychological states.Materials and methodsStudy participants were 101 women (n = 81) and men (n = 20), mean age 53.9 years (SD = 11.7; range 32–80). Participants completed questionnaires to categorize their Vikruti type and psychological states, which included depressed mood (CESD), anxiety (PROMIS), rumination & reflection (RRQ), mindfulness (MAAS), stress (PSS), and quality of life (Ryff).ResultsMultivariate general linear modeling, controlling for age, gender and body mass index (BMI), showed that Vata imbalance was associated with more anxiety (p ≤ 0.05), more rumination (p ≤ 0.01), less mindfulness (p ≤ 0.05), and lower overall quality of life (p ≤ 0.01). Pitta imbalance was associated with poorer mood (p ≤ 0.01) and less mindfulness (p ≤ 0.05), more anxiety (p ≤ 0.05) and stress (p ≤ 0.05). Kapha imbalance was associated with more stress (p ≤ 0.05), more rumination (p ≤ 0.05) and less reflection (p ≤ 0.05).ConclusionThese findings suggest that symptoms of mind-body imbalances in Ayurveda are differentially associated with western assessments of psychological states. Ayurvedic dosha assessment may be an effective way to assess physical as well as emotional wellbeing in research and clinical settings.

“…Mental and physical ill-health weakens dhatusamya (homeostasis), resulting in Akalaja vriddhavastha (pathological aging) [61] , [62] , [66] . Ayurveda takes a holistic approach toward the maintenance of dhatusamya , a state of equilibrium of normal anatomical, biological, physiological, mental and spiritual well-being [66] , [67] . Hence a balanced state ( sama ) of tissue ( dhatu ), energy systems ( Dosha ), heat of transformation ( Agni ) and metabolic wastes ( mala ) constitute homeostasis in Ayurveda that leads to healthy aging ( Sukhayu/Kalaja Vriddhavastha ) [66] , [68] .…”

Section: Ayurveda and Science Of Agingmentioning

confidence: 99%

“…Prakruti refers to the biological constitution (anatomical, physiological and psychological) of an individual. The Prakruti which is unique to each individual reflects the baseline characteristics of the individual including metabolism, mental makeup, immunity, inherent strength and weakness and proclivities [67] , [70] , [71] . Thus, Prakruti determines an individual's capacity for transformation at the physical, mental and emotional levels owing to the interactions with internal and external stimuli all of which affect the aging process [63] , [72] .…”

Section: Ayurveda and Science Of Agingmentioning

confidence: 99%

Ayurveda and the science of aging

Rao

2018

Since time immemorial, humanity has been concerned with developing and preserving youthful vigor, and extending longevity by stopping or delaying the aging process. By 2030, one in five of the world population will be over 65 years old. Longevity and old age are accompanied with a variety of health challenges and population studies indicate that the elderly will use between three to five times more healthcare services compared to the younger population. Modern medicine has made a great deal of progress in understanding the aging process and in controlling age-associated health issues including heart attacks, strokes, diabetes, cancer, senility, and arthritis. Thus, every individual is now looking forward to a youthful, productive lifespan of 100 or more years filled with unlimited health and opportunity. Research by aging experts is focused on ways to go against the natural order of the aging process in order to delay it. Interventions include among other things anti-aging pills, restricted food consumption and cloning body parts to stay young and delay biological aging. Ayurveda, one of the world's most authoritative mind-body-spirit medicinal systems, offers various concepts of the aging process. This system of medicine includes therapies for healthy aging so as to create an optimal health and lengthen an individual's healthspan by living in harmony with nature. This review will explore various aspects of aging and longevity by comparing the science of aging as defined by modern medicine with the Ayurvedic treatise of Jara and Vriddhavastha.